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Multiple regulatory roles of UNC93B1 in innate immunity.

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Τίτλος: Multiple regulatory roles of UNC93B1 in innate immunity.
Συγγραφείς: Yi L; Department of Clinical Laboratory, Yiyang Central Hospital, Yiyang, Hunan, China., Li Y; International Department, Shanghai Private Weiyu Middle School, China., Xiao X; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China., Li J; Department of Family and Community Medicine, University of Illinois College of Medicine, Rockford, IL, USA., Yang Z; Shanghai Omics Biotechnology Co., Ltd, Shanghai, China., Zhang Y; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China. Electronic address: yanzhaozhang@cmu.edu.cn., Xue M; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China. Electronic address: xuemengzhou@zzu.edu.cn., Zheng C; Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address: zheng.alan@hotmail.com.
Πηγή: Cellular signalling [Cell Signal] 2026 Oct; Vol. 146, pp. 112692. Date of Electronic Publication: 2026 Jun 23.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE
Imprint Name(s): Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, 1988-
Ιατρικοί όροι (MeSH): Membrane Transport Proteins*/immunology , Membrane Transport Proteins*/metabolism , Immunity, Innate*, Neutrophils/immunology ; Autoimmune Diseases/immunology ; Virus Diseases/immunology ; Humans ; Animals ; Signal Transduction ; cGAS-STING Signaling Pathway ; Innate Immunity Recognition ; Membrane Proteins ; Toll-Like Receptors
Περίληψη: Uncoordinated 93 homolog B1 (UNC93B1) is a key innate immune regulator that affects the function of pattern recognition receptors. UNC93B1 is responsible for governing the intracellular trafficking and activation of nucleic acid-sensing TLRs. Recently, UNC93B1 was shown to regulate the cGAS/STING signaling pathway. As a result, UNC93B1 is a promising therapeutic target for various human diseases. In this review, we provide an update on new findings establishing the regulatory role of UNC93B1 in innate immunity, including the antibacterial activity of neutrophils, the PRR-mediated signaling pathway, and its specific role in autoimmune illnesses and severe viral infectious diseases. A thorough assessment of the role of UNC93B1 in innate immune regulation will allow us to identify possible novel therapeutic targets in UNC93B1-associated disorders.
(Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors state that there are no relevant financial or nonfinancial conflicting interests to disclose.
Contributed Indexing: Keywords: Innate immunity; NLRP3; STING; TLRs; UNC93B1
Substance Nomenclature: 0 (Membrane Transport Proteins)
0 (UNC93B1 protein, human)
0 (Membrane Proteins)
0 (Toll-Like Receptors)
Entry Date(s): Date Created: 20260623 Date Completed: 20260704 Latest Revision: 20260704
Update Code: 20260705
DOI: 10.1016/j.cellsig.2026.112692
PMID: 42336340
Βάση Δεδομένων: MEDLINE
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  Data: Multiple regulatory roles of UNC93B1 in innate immunity.
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  Data: <searchLink fieldCode="AU" term="%22Yi+L%22">Yi L</searchLink>; Department of Clinical Laboratory, Yiyang Central Hospital, Yiyang, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; International Department, Shanghai Private Weiyu Middle School, China.<br /><searchLink fieldCode="AU" term="%22Xiao+X%22">Xiao X</searchLink>; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Family and Community Medicine, University of Illinois College of Medicine, Rockford, IL, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Shanghai Omics Biotechnology Co., Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China. Electronic address: yanzhaozhang@cmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xue+M%22">Xue M</searchLink>; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China. Electronic address: xuemengzhou@zzu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address: zheng.alan@hotmail.com.
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  Data: <searchLink fieldCode="JN" term="%228904683%22">Cellular signalling</searchLink> [Cell Signal] 2026 Oct; Vol. 146, pp. 112692. <i>Date of Electronic Publication: </i>2026 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8904683 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-3913 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208986568%22">08986568 </searchLink><i>NLM ISO Abbreviation: </i>Cell Signal <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: Oxford : Elsevier Science Ltd<br /><i>Original Publication</i>: Oxford ; New York : Pergamon Press, 1988-
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  Data: <searchLink fieldCode="MM" term="%22Membrane+Transport+Proteins%22">Membrane Transport Proteins*</searchLink>/<searchLink fieldCode="MM" term="%22Membrane+Transport+Proteins+immunology%22">immunology</searchLink> <br /><searchLink fieldCode="MM" term="%22Membrane+Transport+Proteins%22">Membrane Transport Proteins*</searchLink>/<searchLink fieldCode="MM" term="%22Membrane+Transport+Proteins+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Immunity%2C+Innate%22">Immunity, Innate*</searchLink><br /><searchLink fieldCode="MH" term="%22Neutrophils%22">Neutrophils</searchLink>/<searchLink fieldCode="MH" term="%22Neutrophils+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22Autoimmune+Diseases%22">Autoimmune Diseases</searchLink>/<searchLink fieldCode="MH" term="%22Autoimmune+Diseases+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22Virus+Diseases%22">Virus Diseases</searchLink>/<searchLink fieldCode="MH" term="%22Virus+Diseases+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Signal+Transduction%22">Signal Transduction</searchLink> ; <searchLink fieldCode="MH" term="%22cGAS-STING+Signaling+Pathway%22">cGAS-STING Signaling Pathway</searchLink> ; <searchLink fieldCode="MH" term="%22Innate+Immunity+Recognition%22">Innate Immunity Recognition</searchLink> ; <searchLink fieldCode="MH" term="%22Membrane+Proteins%22">Membrane Proteins</searchLink> ; <searchLink fieldCode="MH" term="%22Toll-Like+Receptors%22">Toll-Like Receptors</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Uncoordinated 93 homolog B1 (UNC93B1) is a key innate immune regulator that affects the function of pattern recognition receptors. UNC93B1 is responsible for governing the intracellular trafficking and activation of nucleic acid-sensing TLRs. Recently, UNC93B1 was shown to regulate the cGAS/STING signaling pathway. As a result, UNC93B1 is a promising therapeutic target for various human diseases. In this review, we provide an update on new findings establishing the regulatory role of UNC93B1 in innate immunity, including the antibacterial activity of neutrophils, the PRR-mediated signaling pathway, and its specific role in autoimmune illnesses and severe viral infectious diseases. A thorough assessment of the role of UNC93B1 in innate immune regulation will allow us to identify possible novel therapeutic targets in UNC93B1-associated disorders.<br /> (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of competing interest The authors state that there are no relevant financial or nonfinancial conflicting interests to disclose.
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  Data: <i>Keywords: </i>Innate immunity; NLRP3; STING; TLRs; UNC93B1
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        Text: English
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        StartPage: 112692
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        Type: general
      – SubjectFull: Autoimmune Diseases immunology
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