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Non-invasive brain stimulation and cognitive training for depressive symptoms and cancer-related cognitive impairment in breast cancer survivors (ONCODEP).

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Τίτλος: Non-invasive brain stimulation and cognitive training for depressive symptoms and cancer-related cognitive impairment in breast cancer survivors (ONCODEP).
Συγγραφείς: Salgado-Blanco C; Instituto de Psicoloxía (IPsiUS), Departmento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. Electronic address: cristina.salgado.blanco@rai.usc.es., Alcántara Espinosa JM; Brain and Pain (BaP), Universidade de Santiago de Compostela, Spain., Pinal D; Center for Research in Psychology, Universidade do Minho, Braga, Portugal., Pérez IF; Galicia Sur Health Research Institute (IIS Galicia Sur), Álvaro Cunqueiro Hospital (SERGAS-CHUVI), Spain., Blanco BV; Santiago de Compostela Hospital University Complex (SERGAS-CHUS), Spain., Rodríguez PÁ; Centro Oncológico de Galicia, Spain., Spuch C; Galicia Sur Health Research Institute (IIS Galicia Sur), Álvaro Cunqueiro Hospital (SERGAS-CHUVI), Spain., Carrillo de la Peña MT; Instituto de Psicoloxía (IPsiUS), Departmento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Πηγή: European journal of oncology nursing : the official journal of European Oncology Nursing Society [Eur J Oncol Nurs] 2026 Aug; Vol. 83, pp. 103253. Date of Electronic Publication: 2026 Jun 23.
Τύπος έκδοσης: Journal Article; Randomized Controlled Trial
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100885136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2122 (Electronic) Linking ISSN: 14623889 NLM ISO Abbreviation: Eur J Oncol Nurs Subsets: MEDLINE
Imprint Name(s): Original Publication: Edinburgh ; New York : Churchill Livingstone, c1998-
Ιατρικοί όροι (MeSH): Breast Neoplasms*/psychology , Breast Neoplasms*/complications , Breast Neoplasms*/therapy , Transcranial Direct Current Stimulation*/methods , Depression*/therapy , Depression*/etiology , Cognitive Dysfunction*/therapy , Cognitive Dysfunction*/etiology , Cancer Survivors*/psychology , Cognitive Training*, Humans ; Female ; Middle Aged ; Feasibility Studies ; Treatment Outcome ; Cognitive Enhancement
Περίληψη: Purpose: Depression and cancer-related cognitive impairment (CRCI) are frequent after-effects in breast cancer survivors (BCS). Despite being closely related and sharing some features, there is no intervention addressing them comprehensively. Transcranial direct current (tDCS) and alternating stimulation (tACS), combined with computerized cognitive training (CCT), provided benefits for improving mood and cognition in several populations and have several advantages, but evidence in BCS is limited. This study aims to explore the effectiveness and feasibility of a home-based combined intervention (tDCS or tACS + CCT) to improve depressive symptoms and CRCI in BCS.
Methods: BCS presenting depressive symptoms (Beck Depression Inventory Fast Screen >4) were randomly assigned to four groups: tDCS + CCT; tACS + CCT; sham transcranial stimulation + CCT; CCT. Home-based intervention consisted of 15 daily 20-min sessions combining prefrontal tDCS or tACS simultaneously with CCT. Linear mixed-effects models and Minimal Clinically Important Differences assessed the effectiveness of the intervention on depressive symptoms, cognitive complaints and neuropsychological performance.
Results: Eighty-two BCS participated (range 46.3 - 48.9 years). Most participants completed the intervention without significant side effects. No significant differences between intervention groups were found, although improvements over time were observed across groups in depressive and cognitive outcomes.
Conclusion: The home-based intervention was feasible. Improvements in mood and CRCI were observed, but the additive effect of tDCS/tACS was not demonstrated. Future studies should be powered using population-specific effect sizes, consider other neuromodulation protocols and clinical outcomes and optimize home-based stimulation fidelity. The effectiveness of CCT should be further investigated.
(Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Cancer survivors; Chemobrain; Chemotherapy-related cognitive impairment; Cognitive training; Depression; Transcranial alternating current stimulation; Transcranial direct current stimulation; Transcranial electrical stimulation
Entry Date(s): Date Created: 20260623 Date Completed: 20260723 Latest Revision: 20260824
Update Code: 20260824
DOI: 10.1016/j.ejon.2026.103253
PMID: 42335551
Βάση Δεδομένων: MEDLINE
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  Data: Non-invasive brain stimulation and cognitive training for depressive symptoms and cancer-related cognitive impairment in breast cancer survivors (ONCODEP).
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  Data: <searchLink fieldCode="AU" term="%22Salgado-Blanco+C%22">Salgado-Blanco C</searchLink>; Instituto de Psicoloxía (IPsiUS), Departmento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. Electronic address: cristina.salgado.blanco@rai.usc.es.<br /><searchLink fieldCode="AU" term="%22Alcántara+Espinosa+JM%22">Alcántara Espinosa JM</searchLink>; Brain and Pain (BaP), Universidade de Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Pinal+D%22">Pinal D</searchLink>; Center for Research in Psychology, Universidade do Minho, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Pérez+IF%22">Pérez IF</searchLink>; Galicia Sur Health Research Institute (IIS Galicia Sur), Álvaro Cunqueiro Hospital (SERGAS-CHUVI), Spain.<br /><searchLink fieldCode="AU" term="%22Blanco+BV%22">Blanco BV</searchLink>; Santiago de Compostela Hospital University Complex (SERGAS-CHUS), Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+PÁ%22">Rodríguez PÁ</searchLink>; Centro Oncológico de Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Spuch+C%22">Spuch C</searchLink>; Galicia Sur Health Research Institute (IIS Galicia Sur), Álvaro Cunqueiro Hospital (SERGAS-CHUVI), Spain.<br /><searchLink fieldCode="AU" term="%22Carrillo+de+la+Peña+MT%22">Carrillo de la Peña MT</searchLink>; Instituto de Psicoloxía (IPsiUS), Departmento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Churchill+Livingstone%22">Churchill Livingstone </searchLink><i>Country of Publication: </i>Scotland <i>NLM ID: </i>100885136 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-2122 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214623889%22">14623889 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Oncol Nurs <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: Edinburgh ; New York : Churchill Livingstone, c1998-
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  Data: <searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+psychology%22">psychology</searchLink> <br /><searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Breast+Neoplasms%22">Breast Neoplasms*</searchLink>/<searchLink fieldCode="MM" term="%22Breast+Neoplasms+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Transcranial+Direct+Current+Stimulation%22">Transcranial Direct Current Stimulation*</searchLink>/<searchLink fieldCode="MM" term="%22Transcranial+Direct+Current+Stimulation+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Depression%22">Depression*</searchLink>/<searchLink fieldCode="MM" term="%22Depression+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Depression%22">Depression*</searchLink>/<searchLink fieldCode="MM" term="%22Depression+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cognitive+Dysfunction%22">Cognitive Dysfunction*</searchLink>/<searchLink fieldCode="MM" term="%22Cognitive+Dysfunction+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Cognitive+Dysfunction%22">Cognitive Dysfunction*</searchLink>/<searchLink fieldCode="MM" term="%22Cognitive+Dysfunction+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cancer+Survivors%22">Cancer Survivors*</searchLink>/<searchLink fieldCode="MM" term="%22Cancer+Survivors+psychology%22">psychology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cognitive+Training%22">Cognitive Training*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Feasibility+Studies%22">Feasibility Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink> ; <searchLink fieldCode="MH" term="%22Cognitive+Enhancement%22">Cognitive Enhancement</searchLink>
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  Data: Purpose: Depression and cancer-related cognitive impairment (CRCI) are frequent after-effects in breast cancer survivors (BCS). Despite being closely related and sharing some features, there is no intervention addressing them comprehensively. Transcranial direct current (tDCS) and alternating stimulation (tACS), combined with computerized cognitive training (CCT), provided benefits for improving mood and cognition in several populations and have several advantages, but evidence in BCS is limited. This study aims to explore the effectiveness and feasibility of a home-based combined intervention (tDCS or tACS + CCT) to improve depressive symptoms and CRCI in BCS.<br />Methods: BCS presenting depressive symptoms (Beck Depression Inventory Fast Screen >4) were randomly assigned to four groups: tDCS + CCT; tACS + CCT; sham transcranial stimulation + CCT; CCT. Home-based intervention consisted of 15 daily 20-min sessions combining prefrontal tDCS or tACS simultaneously with CCT. Linear mixed-effects models and Minimal Clinically Important Differences assessed the effectiveness of the intervention on depressive symptoms, cognitive complaints and neuropsychological performance.<br />Results: Eighty-two BCS participated (range 46.3 - 48.9 years). Most participants completed the intervention without significant side effects. No significant differences between intervention groups were found, although improvements over time were observed across groups in depressive and cognitive outcomes.<br />Conclusion: The home-based intervention was feasible. Improvements in mood and CRCI were observed, but the additive effect of tDCS/tACS was not demonstrated. Future studies should be powered using population-specific effect sizes, consider other neuromodulation protocols and clinical outcomes and optimize home-based stimulation fidelity. The effectiveness of CCT should be further investigated.<br /> (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Cancer survivors; Chemobrain; Chemotherapy-related cognitive impairment; Cognitive training; Depression; Transcranial alternating current stimulation; Transcranial direct current stimulation; Transcranial electrical stimulation
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