Academic Journal
Sex-Dependent Neurochemical Encoding of Acute Social Experience in Adult CD1 Mice.
| Τίτλος: | Sex-Dependent Neurochemical Encoding of Acute Social Experience in Adult CD1 Mice. |
|---|---|
| Συγγραφείς: | Azkona G; Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain., Díez-Solinska A; Department of Health Sciences, Public University of Navarre, Pamplona, Spain., Saez-Atxukarro O; Department of Health Sciences, Public University of Navarre, Pamplona, Spain., Ochoteco-Perales L; Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain., Beitia-Oyarzabal G; Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain., Vegas O; Department of Basic Psychological Processes and Their Development, University of the Basque Country (UPV/EHU), Donostia-San Sebastian, Spain.; Biogipuzkoa Health Research Institute, Donostia-San Sebastian, Spain. |
| Πηγή: | Journal of neurochemistry [J Neurochem] 2026 Jun; Vol. 170 (6), pp. e70509. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry Original Publication: New York : Raven Press |
| Ιατρικοί όροι (MeSH): | Brain*/metabolism , Sex Characteristics* , Social Interaction* , Social Behavior*, Animals ; Female ; Male ; Mice ; Corticosterone |
| Περίληψη: | Acute social interaction rapidly engages physiological and neurochemical systems, yet the extent to which these responses differ between sexes remains incompletely understood. Here, we investigated behavioural, endocrine and region-specific neurochemical responses to a brief social challenge using the social interaction test in adult male and female CD1 mice. Behavioural performance was comparable between sexes, with similar levels of social interaction and locomotor activity. In contrast, endocrine measures revealed a robust stress response, as corticosterone markedly increased after social challenge. Estradiol and progesterone levels also increased following the social challenge, whereas testosterone exhibited the expected sexual dimorphism. Neurochemical profiling revealed widespread and region-dependent effects. The brainstem showed manipulation-driven increases in glutamatergic and catecholaminergic markers across sexes. In the striatum, social interaction preferentially enhanced glutamatergic metabolites in males, whereas females displayed stronger monoaminergic signatures. The hippocampus exhibited the most pronounced sex-dependent modulation, involving amino-acid precursors, catecholaminergic turnover indices, noradrenergic metabolites and kynurenine-pathway ratios. By contrast, neurochemical organisation in the prefrontal cortex was predominantly shaped by baseline sexual dimorphism rather than acute social exposure. Correlation analyses between plasma hormones and regional neurochemical markers revealed limited and inconsistent associations, suggesting a relative dissociation between endocrine and neurochemical responses to the social challenge. Together, these findings demonstrate that acute social interaction induces broad endocrine and neurochemical adaptations while revealing distinct, region-specific sex signatures in neurochemical regulation. (© 2026 The Author(s). Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.) |
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| Grant Information: | IT1447-22 Eusko Jaurlaritza |
| Contributed Indexing: | Keywords: monoamines; neurotransmitter metabolism; sex differences; social interaction test |
| Substance Nomenclature: | W980KJ009P (Corticosterone) |
| Entry Date(s): | Date Created: 20260623 Date Completed: 20260623 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13287558 |
| DOI: | 10.1111/jnc.70509 |
| PMID: | 42333056 |
| Βάση Δεδομένων: | MEDLINE |
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