Academic Journal
Machine-intelligent multimodal algebot for intracavitary chemotherapy.
| Τίτλος: | Machine-intelligent multimodal algebot for intracavitary chemotherapy. |
|---|---|
| Συγγραφείς: | Lin L; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Li H; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Zhou Q; Institute for Neuroscience and Cardiovascular Research & The ZJE Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK. q.zhou@ed.ac.uk., Ding Q; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.; Sauvage Laboratory for Smart Materials & School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China., Sun X; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Hu J; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Zhao Z; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Qin Y; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Department of Laboratory Medicine, School of Public Health, Xiamen University, Xiamen, China., Jiang T; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.; Sauvage Laboratory for Smart Materials & School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China., Ye H; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Wu X; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China., Liu H; Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems & School of Life Sciences, Xiamen University, Xiamen, China., Huang L; Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems & School of Life Sciences, Xiamen University, Xiamen, China., Huang C; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Department of Laboratory Medicine, School of Public Health, Xiamen University, Xiamen, China., Gao Y; Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems & School of Life Sciences, Xiamen University, Xiamen, China., Tang J; Department of Chemistry, The University of Hong Kong, Hong Kong, China. jinyao@hku.hk.; State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, China. jinyao@hku.hk., Ma X; Sauvage Laboratory for Smart Materials & School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China. maxing@hit.edu.cn., Yan X; State Key Laboratory of Vaccines for Infectious Diseases & Fujian Engineering Research Center of Molecular Theranostic Technology, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China. xhyan@xmu.edu.cn. |
| Πηγή: | Nature nanotechnology [Nat Nanotechnol] 2026 Jul; Vol. 21 (7), pp. 996-1007. Date of Electronic Publication: 2026 Jun 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Pub. Group, 2006- |
| Ιατρικοί όροι (MeSH): | Doxorubicin*/administration & dosage , Doxorubicin*/pharmacology , Doxorubicin*/pharmacokinetics , Doxorubicin*/therapeutic use , Doxorubicin*/chemistry , Urinary Bladder Neoplasms*/drug therapy , Urinary Bladder Neoplasms*/pathology , Drug Delivery Systems*/methods , Antineoplastic Agents*/administration & dosage, Animals ; Mice ; Humans ; Cell Line, Tumor |
| Περίληψη: | Intracavitary drug instillation is a crucial therapeutic strategy for treating bladder cancer. However, current methods are limited in efficacy due to insufficient tumour targeting and drug penetration across tissue barriers in pathophysiological conditions. Here we devise biohybrid magnetic algae microrobots with hierarchical nanoporous structure and develop an 'algebot'-mediated, non-contact convective transport strategy to synergistically integrate targeted carrier transport, selective drug release and ultrafast tissue penetration. Our approach leverages machine-intelligent image feedback for autonomous navigation, magnetite-endowed multimodal control for reconfigurable swarming and flow-tuned convective diffusion for on-demand therapeutic delivery. We exemplify this approach with doxorubicin-loaded magnetic Coscinodiscus granii evaluated in a murine model of bladder tumour, demonstrating an over tenfold increase in drug permeation and substantially reduced tumour burden to less than 3% compared with conventional intravesical instillation in a preclinical trial of 1-week therapy without inducing systemic toxicity. Our drug delivery system offers a non-invasive solution to overcome complex biological barriers, advancing the efficacy and safety of intracavitary chemotherapy. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: X.Y., Q.D., L.L. and X.S. are inventors on a Chinese patent application (CN 121176887 A) related to the technology described in this paper. The other authors declare no competing interests. |
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| Substance Nomenclature: | 80168379AG (Doxorubicin) 0 (Antineoplastic Agents) |
| Entry Date(s): | Date Created: 20260622 Date Completed: 20260717 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13379317 |
| DOI: | 10.1038/s41565-026-02195-0 |
| PMID: | 42332250 |
| Βάση Δεδομένων: | MEDLINE |
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