Academic Journal
BAMBI: A Ca2+ imaging-based brain-computer interface for longitudinal neuronal tracking in freely behaving mice.
| Τίτλος: | BAMBI: A Ca2+ imaging-based brain-computer interface for longitudinal neuronal tracking in freely behaving mice. |
|---|---|
| Συγγραφείς: | Balilti-Turgeman L; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Shalvi N; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Pinchasof O; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Geva N; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Deitch D; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Rubin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Ziv Y; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: yaniv.ziv@weizmann.ac.il. |
| Πηγή: | Journal of neuroscience methods [J Neurosci Methods] 2026 Oct; Vol. 434, pp. 110832. Date of Electronic Publication: 2026 Jun 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7905558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-678X (Electronic) Linking ISSN: 01650270 NLM ISO Abbreviation: J Neurosci Methods Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Neurons*/physiology , Neurons*/metabolism , Calcium*/metabolism , Hippocampus*/physiology , Hippocampus*/cytology , Behavior, Animal*/physiology , Brain-Computer Interfaces*, Animals ; Mice ; Mice, Inbred C57BL ; Male |
| Περίληψη: | Background: Brain-computer interfaces (BCIs) are powerful tools for investigating neuronal dynamics underlying cognitive processes. However, BCIs commonly rely on electrophysiological techniques, which are limited in their ability to track populations of the same neurons over long periods, constraining their utility for studying long-term neuronal processes. New Method: To address this, we developed a BCI system, BAMBI (BCI Applying Mini-microscopes and Behavioral Imaging), which provides feedback based on real-time Ca2+ imaging that tracks neuronal activity over extended periods in freely behaving mice. Results: By maintaining a stable alignment of the same field of view over multiple sessions, BAMBI can reliably track the same neurons over multiple days without requiring retraining. We validated BAMBI using distinct behavioral paradigms in head-fixed and freely moving conditions and demonstrated that mice can reliably modulate specific hippocampal neurons to obtain rewards over multiple days. Comparison With Existing Methods: Previous Ca2+ imaging based BCI applications have been largely limited to head-fixed conditions or lacked in-vivo proof-of-concept and have not demonstrated stable BCI performance across days. Conclusions: Our results establish Ca2+ imaging-based BCI as a tool for longitudinal studies of neuronal population dynamics over extended timescales. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Yaniv Ziv reports financial support, administrative support, article publishing charges, and equipment, drugs, or supplies were provided by Weizmann Institute of Science. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper |
| Contributed Indexing: | Keywords: Brain-computer interface; Calcium imaging; Hippocampus; Longitudinal analysis; Miniature microscopes; Place cells; Representational drift |
| Substance Nomenclature: | SY7Q814VUP (Calcium) |
| Entry Date(s): | Date Created: 20260622 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260709 |
| DOI: | 10.1016/j.jneumeth.2026.110832 |
| PMID: | 42331292 |
| Βάση Δεδομένων: | MEDLINE |
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