Academic Journal
Biomechanical characterization of the female rectum in vivo through MRI-based inverse finite element analysis.
| Τίτλος: | Biomechanical characterization of the female rectum in vivo through MRI-based inverse finite element analysis. |
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| Συγγραφείς: | Silva AT; Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias S/N, Porto, 4200-465, Portugal; LAETA, INEGI, Rua Dr. Roberto Frias S/N, Porto 400, 4200-465, Portugal. Electronic address: tcsilva@inegi.up.pt., Martins M; Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias S/N, Porto, 4200-465, Portugal. Electronic address: up202308697@edu.fe.up.pt., Ferreira NM; Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias S/N, Porto, 4200-465, Portugal; LAETA, INEGI, Rua Dr. Roberto Frias S/N, Porto 400, 4200-465, Portugal. Electronic address: nmferreira@inegi.up.pt., Parente M; Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias S/N, Porto, 4200-465, Portugal; LAETA, INEGI, Rua Dr. Roberto Frias S/N, Porto 400, 4200-465, Portugal. Electronic address: mparente@fe.up.pt., Brandão S; Escola Superior De Saúde Do Vale Do Ave, Cooperativa De Ensino Superior Politécnico e Universitário, Rua José António Vidal, 81, 4760-409 Vila Nova De Famalicão, Portugal; H2M - Health and Human Movement Unit, Polytechnic University of Health, Cooperativa De Ensino Superior Politécnico e Universitário, Cooperativa De Responsabilidade Limitada, 4760-409 Vila Nova De Famalicão, Portugal. Electronic address: fernanda.brandao@ipsn.cespu.pt., Silva E; Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias S/N, Porto, 4200-465, Portugal; LAETA, INEGI, Rua Dr. Roberto Frias S/N, Porto 400, 4200-465, Portugal. Electronic address: mesilva@inegi.up.pt. |
| Πηγή: | Journal of biomechanics [J Biomech] 2026 Aug; Vol. 205, pp. 113406. Date of Electronic Publication: 2026 Jun 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0157375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2380 (Electronic) Linking ISSN: 00219290 NLM ISO Abbreviation: J Biomech Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York ; Oxford : Elsevier Science |
| Ιατρικοί όροι (MeSH): | Magnetic Resonance Imaging*/methods , Rectum*/physiopathology , Rectum*/diagnostic imaging , Rectal Prolapse*/physiopathology , Rectal Prolapse*/diagnostic imaging , Models, Biological*, Female ; Humans ; Finite Element Analysis ; Biomechanical Phenomena ; Middle Aged ; Aged |
| Περίληψη: | Rectal prolapse is a pelvic floor disorder characterized by pathological descent of the rectum resulting from impaired pelvic support. Understanding the rectum's in vivo biomechanical behavior is essential for improving diagnosis and treatment planning. This study aimed to estimate the in vivo mechanical properties of the rectum using inverse finite element analysis (FEA) driven by magnetic resonance imaging (MRI) data. MRI scans from six women (three with rectal prolapse and three asymptomatic controls) were analyzed to quantify supero-inferior (SI) and antero-posterior (AP) rectal displacements, as well as puborectalis muscle thickness. A previously validated three-dimensional pelvic model was adapted to simulate the Valsalva maneuver under an intra-abdominal pressure (IAP) of 4 kPa. Rectal tissue was modeled using a Yeoh hyperelastic formulation, with material parameters optimized through inverse FEA by minimizing the discrepancy between experimental and simulated displacements. The prolapse group exhibited a marked increase in SI displacement (26.22 mm) compared to controls (3.44 mm), together with reduced puborectalis muscle thickness. The optimized model indicated a 28% reduction in rectal stiffness in women with prolapse. Numerical simulations further showed increased SI displacement of the bladder neck in the prolapse group (9.73 mm) compared to asymptomatic controls (6.40 mm), indicating that biomechanical impairment extends beyond the rectum to the anterior pelvic compartment. This difference corresponds to approximately 34% of the SI bladder neck displacement observed in the prolapse group. Inverse FEA based on in vivo MRI enables non-invasive characterization of rectal tissue mechanics, with potential applications in patient-specific diagnosis, surgical planning, and outcome prediction. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Inverse finite element analysis; Magnetic resonance imaging; Rectal prolapse |
| Entry Date(s): | Date Created: 20260622 Date Completed: 20260804 Latest Revision: 20260804 |
| Update Code: | 20260810 |
| DOI: | 10.1016/j.jbiomech.2026.113406 |
| PMID: | 42330572 |
| Βάση Δεδομένων: | MEDLINE |
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