Academic Journal
The minimal clinically important difference for the Sniffin' Sticks Identification Test-16 in patients with chronic rhinosinusitis with nasal polyps treated with biologics.
| Τίτλος: | The minimal clinically important difference for the Sniffin' Sticks Identification Test-16 in patients with chronic rhinosinusitis with nasal polyps treated with biologics. |
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| Συγγραφείς: | Pedersen CK; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Høj S; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Høxbro M; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Homøe AS; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Scott SI; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Aanæs K; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Petersen TS; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Pharmacology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark., von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Backer V; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. |
| Πηγή: | Acta oto-laryngologica [Acta Otolaryngol] 2026 Oct; Vol. 146 (10), pp. 1263-1270. Date of Electronic Publication: 2026 Jun 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2251 (Electronic) Linking ISSN: 00016489 NLM ISO Abbreviation: Acta Otolaryngol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: Stockholm : Scandinavian University Press |
| Ιατρικοί όροι (MeSH): | Rhinosinusitis*/drug therapy , Rhinosinusitis*/complications , Nasal Polyps*/complications , Nasal Polyps*/drug therapy , Biological Products*/therapeutic use , Olfaction Disorders*/diagnosis , Olfaction Disorders*/etiology , Sinusitis*/complications , Sinusitis*/drug therapy , Rhinitis*/complications , Rhinitis*/drug therapy , Minimal Clinically Important Difference* , Smell*, Humans ; Female ; Chronic Disease ; Male ; Middle Aged ; Adult ; Aged |
| Περίληψη: | Background: The Minimal Clinically Important Difference (MCID) reflects the smallest change in a test score perceived as relevant by the patient. MCIDs vary according to disease and clinical context. The Sniffin' Sticks Identification Test 16 (SSIT-16) is a commonly used smell assessment tool, but its MCID in severe chronic rhinosinusitis with nasal polyps (CRSwNP) is unknown. Objective: To determine the MCID of SSIT-16 in severe CRSwNP treated with biologics. Materials and Methods: We analysed change scores from baseline to week 24 in 313 patients. The MCID was estimated using anchor-based and distribution-based methods. Anchors included a visual analogue scale (VAS) for smell, the rhinologic domain of SNOT-22, and the smell/taste item of SNOT-22. Distribution-based analyses included half a standard deviation of baseline SSIT-16 scores, the standard error of measurement (SEM), and the individual-level smallest detectable change. Results: The smell VAS performed best and was therefore chosen as the primary anchor. The optimal ΔSSIT-16 cut-off, balancing sensitivity (78%) and specificity (84%), was 3.5 points. This estimate was supported by distribution-based, sensitivity, and subgroup analyses. Conclusion and Significance: An improvement of approximately 3.5 SSIT-16 points appears to reflect clinically meaningful change in biologically treated patients with severe CRSwNP and may serve as a pragmatic threshold for interpreting olfactory outcomes. |
| Contributed Indexing: | Keywords: Biological treatment; chronic rhinosinusitis; olfaction disorders; smell; type-2 inflammation |
| Substance Nomenclature: | 0 (Biological Products) |
| Entry Date(s): | Date Created: 20260621 Date Completed: 20260929 Latest Revision: 20260929 |
| Update Code: | 20260929 |
| DOI: | 10.1080/00016489.2026.2683697 |
| PMID: | 42323722 |
| Βάση Δεδομένων: | MEDLINE |
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