Academic Journal
Optical coherence tomography angiography imaging characteristics and clinical significance of the foveal vertical hyperreflective line in patients with macular neovascularisation.
| Τίτλος: | Optical coherence tomography angiography imaging characteristics and clinical significance of the foveal vertical hyperreflective line in patients with macular neovascularisation. |
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| Συγγραφείς: | Zhang Y; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. zhangyixiaoyao127@163.com., Gao J; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Zhou A; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Wang J; Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. |
| Πηγή: | Eye (London, England) [Eye (Lond)] 2026 Sep; Vol. 40 (13), pp. 2061-2068. Date of Electronic Publication: 2026 Jun 20. |
| Τύπος έκδοσης: | Journal Article; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8703986 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5454 (Electronic) Linking ISSN: 0950222X NLM ISO Abbreviation: Eye (Lond) Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2003->: London : Nature Publishing Group Original Publication: [London : Ophthalmological Society of the United Kingdom, 1987- |
| Ιατρικοί όροι (MeSH): | Tomography, Optical Coherence*/methods , Fovea Centralis*/diagnostic imaging , Fovea Centralis*/pathology , Fluorescein Angiography*/methods , Retinal Neovascularization*/diagnostic imaging , Retinal Neovascularization*/physiopathology, Visual Acuity/physiology ; Humans ; Retrospective Studies ; Female ; Male ; Aged ; Middle Aged ; Aged, 80 and over ; Fundus Oculi |
| Περίληψη: | Background: To investigate the incidence, characteristic manifestations, outcomes of changes, and potential clinical significance of the foveal vertical hyperreflective line (FVHL) on optical coherence tomography angiography (OCTA) in patients with macular neovascularisation (MNV). Methods: This retrospective observational case series was conducted using OCTA images, fundus photographs, best-corrected visual acuity measurements, and other clinical information of the eyes of patients with MNV who were followed up for at least 3 months between January 2024 and October 2025. The incidence of FVHLs, OCTA characteristics, FVHL changes, and prognoses were analysed. Results: Among the 322 eyes of 161 patients with MNV, 14 patients (8.7%) showed FVHLs in 15 eyes. The mean age of the patients was 69.29 ± 12.68 years. Among the eyes with an FVHL, 13 were of patients with age-related macular degeneration-MNV and two were of patients with pathological myopia-MNV. All cases showing FVHLs occurred in the early stages of the disease course (within 1-3 months) and did not disappear during follow-up. Among the cases with FVHLs, 80% showed no obvious changes in the FVHLs and 20% showed weakened reflexes. The eyes that showed FVHL maintenance had a higher interdigitation zone/ellipsoid zone (IZ/EZ) repair rate (91.7%) than those with reflex-weakened FVHLs (p = 0.009). Conclusions: FVHLs were present in 8.7% of patients with MNV. The eyes that maintained FVHLs exhibited a higher degree of IZ/EZ restoration than the eyes with reflex-weakened FVHLs. This OCTA finding may provide a foundation for assessing the recovery responses of retinal photoreceptors and Müller cells. (© 2026. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
| References: | Sheth JU, Stewart MW, Narayanan R, Anantharaman G, Chandran K, Lai TYY, et al. Macular neovascularization. Surv Ophthalmol. 2025;70:653–75. (PMID: 10.1016/j.survophthal.2024.08.00339222802) Cheng S, Zhang S, Huang M, Liu Y, Zou X, Chen X, et al. Treatment of neovascular age-related macular degeneration with anti-vascular endothelial growth factor drugs: progress from mechanisms to clinical applications. Front Med (Lausanne). 2024;11:1411278. (PMID: 10.3389/fmed.2024.14112783909959511294244) Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, et al. Intraretinal hyperreflective lines. Retina. 2021;41:82–92. (PMID: 10.1097/IAE.000000000000280632251237) Rein AP, Totah H, Brosh K, Zadok D, Hanhart J. Foveal hyper-reflective vertical lines detected by optical coherence tomography: Imaging features, literature review and differential diagnoses. Graefes Arch Clin Exp Ophthalmol. 2025;263:849–55. (PMID: 10.1007/s00417-024-06616-539404899) Chen KC, Jung JJ, Curcio CA, Balaratnasingam C, Gallego-Pinazo R, Dolz-Marco R, et al. Intraretinal hyperreflective foci in acquired vitelliform lesions of the macula: clinical and histologic study. Am J Ophthalmol. 2016;164:89–98. (PMID: 10.1016/j.ajo.2016.02.00226868959) Pereira F, Lima LH, de Azevedo AGB, Zett C, Farah ME, Belfort R Jr. Swept-source OCT in patients with multiple evanescent white dot syndrome. J Ophthalmic Inflamm Infect. 2018;8:16. (PMID: 10.1186/s12348-018-0159-2303173986186261) Scharf JM, Hilely A, Preti RC, Grondin C, Chehaibou I, Greaves G, et al. Hyperreflective stress lines and macular holes. Invest Ophthalmol Vis Sci. 2020;61:50. (PMID: 10.1167/iovs.61.4.50323479197401923) Arrigo A, Aragona E, Antropoli A, Bianco L, Rosolia A, Saladino A, et al. Foveal eversion is associated with high persistence of macular edema and visual acuity deterioration in retinal vein occlusion. Ophthalmol Ther. 2023;12:2157–69. (PMID: 10.1007/s40123-023-00734-93729452310287597) Taiji H, Naonori M, Nahoko O. Highly reflective line in optical coherence tomography images of eyes with macular edema associated with branch retinal vein occlusion. Am J Ophthalmol. 2015;159:925–33.e1. (PMID: 10.1016/j.ajo.2015.01.033) Yamada E. Some structural features of the fovea centralis in the human retina. Arch Ophthalmol. 1969;82:151–9. (PMID: 10.1001/archopht.1969.009900201530024183671) Gass JD. Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis. Arch Ophthalmol. 1999;117:821–3. (PMID: 10.1001/archopht.117.6.82110369597) Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, et al. Müller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25:397–424. (PMID: 10.1016/j.preteyeres.2006.05.00316839797) Bringmann A, Syrbe S, Görner K, Kacza J, Francke M, Wiedemann P, et al. The primate fovea: structure, function and development. Prog Retin Eye Res. 2018;66:49–84. (PMID: 10.1016/j.preteyeres.2018.03.00629609042) Syrbe S, Kuhrt H, Gärtner U, Habermann G, Wiedemann P, Bringmann A, et al. Müller glial cells of the primate foveola: an electron microscopical study. Exp Eye Res. 2018;167:110–7. (PMID: 10.1016/j.exer.2017.12.00429242027) Chung H, Byeon SH. New insights into the pathoanatomy of macular holes based on features of optical coherence tomography. Surv Ophthalmol. 2017;62:506–21. (PMID: 10.1016/j.survophthal.2017.03.00328300548) Tschulakow AV, Oltrup T, Bende T, Schmelzle S, Schraermeyer U. The anatomy of the foveola reinvestigated. PeerJ. 2018;6:e4482. (PMID: 10.7717/peerj.4482295769575853608) Arrigo A, Cremona O, Aragona E, Casoni F, Consalez G, Dogru RM, et al. Müller cells trophism and pathology as the next therapeutic targets for retinal diseases. Prog Retin Eye Res. 2025;106:101357. (PMID: 10.1016/j.preteyeres.2025.10135740254246) Yokotsuka K, Kishi S, Shimizu K. White dot fovea. Am J Ophthalmol. 1997;123:76–83. (PMID: 10.1016/S0002-9394(14)70995-X9186100) Corradetti G, Au A, Borrelli E, Xu X, Freund KB, Sarraf D. Analysis of hyperreflective dots within the central fovea in healthy eyes using en face optical coherence tomography. Invest Ophthalmol Vis Sci. 2019;60:4451–61. (PMID: 10.1167/iovs.19-2747631652329) Pole C, Au A, Navajas E, Freund KB, Sadda S, Sarraf D. En face optical coherence tomography imaging of foveal dots in eyes with posterior vitreous detachment or internal limiting membrane peeling. Invest Ophthalmol Vis Sci. 2021;62:5. (PMID: 10.1167/iovs.62.10.5343513578354030) Cicinelli MV, Menean M, Apuzzo A, Scandale P, Marchese A, Introini U, et al. Presumed Müller cell activation in multiple evanescent white dot syndrome. Invest Ophthalmol Vis Sci. 2023;64:20. (PMID: 10.1167/iovs.64.13.203782413510587856) Wilson JD, Cottrell WJ, Foster TH. Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes. J Biomed Opt. 2007;12:014010. (PMID: 10.1117/1.243776517343485) Hutto RA, Rutter KM, Giarmarco MM, Parker ED, Chambers ZS, Brockerhoff SE. Cone photoreceptors transfer damaged mitochondria to Müller glia. Cell Rep. 2023;42:112115. (PMID: 10.1016/j.celrep.2023.1121153679556510425575) Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, et al. Light-driven regeneration of cone visual pigments through a mechanism involving RGR opsin in Müller glial cells. Neuron. 2019;102:1172–83. (PMID: 10.1016/j.neuron.2019.04.004310563536586478) Mat Nor MN, Guo CX, Green CR, Squirrell D, Acosta ML. Hyper-reflective dots in optical coherence tomography imaging and inflammation markers in diabetic retinopathy. J Anat. 2023;243:697–705. (PMID: 10.1111/joa.138893722226110485584) |
| Grant Information: | 82501291 National Natural Science Foundation of China (National Science Foundation of China) |
| Entry Date(s): | Date Created: 20260620 Date Completed: 20260903 Latest Revision: 20260914 |
| Update Code: | 20260915 |
| PubMed Central ID: | PMC13538548 |
| DOI: | 10.1038/s41433-026-04647-2 |
| PMID: | 42323420 |
| Βάση Δεδομένων: | MEDLINE |
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