Academic Journal
Patterns of onset and progression of psychoses induced by psychoactive substance use.
| Τίτλος: | Patterns of onset and progression of psychoses induced by psychoactive substance use. |
|---|---|
| Συγγραφείς: | Ifteni P; Transilvania University of Brașov, Romania, Faculty of Medicine, 29 Eroilor Bld., 500036, Brașov, Romania; Spitalul Clinic de Psihiatrie si Neurologie Brașov, 7-9 Prundului Str., 500123, Brașov, Romania., Miron AA; Transilvania University of Brașov, Romania, Faculty of Medicine, 29 Eroilor Bld., 500036, Brașov, Romania; Spitalul Clinic de Psihiatrie si Neurologie Brașov, 7-9 Prundului Str., 500123, Brașov, Romania. Electronic address: aliana.miron@unitbv.ro., Necula R; Spitalul Clinic de Psihiatrie si Neurologie Brașov, 7-9 Prundului Str., 500123, Brașov, Romania., Dima L; Transilvania University of Brașov, Romania, Faculty of Medicine, 29 Eroilor Bld., 500036, Brașov, Romania., Teodorescu A; Transilvania University of Brașov, Romania, Faculty of Medicine, 29 Eroilor Bld., 500036, Brașov, Romania; Spitalul Clinic de Psihiatrie si Neurologie Brașov, 7-9 Prundului Str., 500123, Brașov, Romania. |
| Πηγή: | Psychiatry research [Psychiatry Res] 2026 Oct; Vol. 364, pp. 117283. Date of Electronic Publication: 2026 Jun 15. |
| Τύπος έκδοσης: | Journal Article; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 7911385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7123 (Electronic) Linking ISSN: 01651781 NLM ISO Abbreviation: Psychiatry Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier/North-Holland Biomedical Press Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Psychoses, Substance-Induced*/epidemiology , Psychoses, Substance-Induced*/etiology , Psychotropic Drugs*/adverse effects , Schizophrenia*/epidemiology , Substance-Related Disorders*/complications , Substance-Related Disorders*/epidemiology , Psychotic Disorders*/etiology , Psychotic Disorders*/epidemiology , Bipolar Disorder*/epidemiology, Humans ; Retrospective Studies ; Disease Progression ; Adult ; Male ; Female ; Young Adult ; Middle Aged |
| Περίληψη: | Introduction: Drug use in Europe has increased in recent years, including a marked rise in new psychoactive substances (NPS). Substance use disorders negatively affect physical and mental health. Psychotic disorders are highly prevalent among drug users. Establishing a link between illicit drug use and schizophrenia would help clarify the progression risk after substance-induced psychosis. Aims: To investigate the onset and evolution of substance-induced psychosis in patients hospitalized in Brașov Clinical Hospital of Psychiatry and Neurology. Materials and Methods: A retrospective observational study, analyzing data from all the patients admitted to the hospital between 2014 and 2024, who were diagnosed with substance-induced psychosis other than alcohol, according to DSM-5 criteria. Results: Of all admissions, 2353 (9.6%) were diagnosed with acute psychotic disorders, of which 129 (5.5%) were related to psychoactive substances. THC (cannabis) was the main substance used, being present in 82.95% of cases. Almost half of the patients (44.96%) reported multiple drug use. 48.84% of patients required subsequent psychiatric readmissions after a first episode of substance-induced psychosis. 11.62% of the patients with substance-induced psychosis were subsequently diagnosed with a major psychiatric disorder, schizophrenia (N = 10, 7.8%) or bipolar disorder (N = 5, 3.9%). The mean duration of conversion to a major psychiatric disorder was 3.37±3.38 years. Conclusions: Substance-induced psychosis carried a meaningful risk of later transition to schizophrenia-spectrum or bipolar disorders, particularly among patients with higher-risk substance patterns and other vulnerability factors. THC was the most frequently used substance and emerged as an important risk marker in this cohort, supporting the need for timely recognition, sustained follow-up, and integrated intervention for high-risk patients. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Cannabis; Drug-induced psychosis; Drugs; Psychosis; Schizophrenia |
| Substance Nomenclature: | 0 (Psychotropic Drugs) |
| Entry Date(s): | Date Created: 20260619 Date Completed: 20260810 Latest Revision: 20260817 |
| Update Code: | 20260818 |
| DOI: | 10.1016/j.psychres.2026.117283 |
| PMID: | 42320288 |
| Βάση Δεδομένων: | MEDLINE |
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