Academic Journal
Proteomic signatures of mitochondrial dysfunction associated with atrial fibrillation in goats.
| Τίτλος: | Proteomic signatures of mitochondrial dysfunction associated with atrial fibrillation in goats. |
|---|---|
| Συγγραφείς: | Ayagama T; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Barrett-Jolley R; Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK. rbj@liverpool.ac.uk., Fischer R; Target Discovery Institute/Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hester SS; Target Discovery Institute/Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Schotten U; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Verheule S; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Burton RA; Institute of Systems, Molecular and Integrative Biology, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK. rabb@liverpool.ac.uk.; Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK. rabb@liverpool.ac.uk.; Department of Pharmacology, University of Oxford, Oxford, UK. rabb@liverpool.ac.uk. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Jun 18; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 18. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Proteomics*/methods , Atrial Fibrillation*/metabolism , Atrial Fibrillation*/pathology , Mitochondria, Heart*/metabolism , Mitochondria*/metabolism , Proteome*/metabolism, Heart Atria/metabolism ; Animals ; Goats ; Oxidative Phosphorylation |
| Περίληψη: | Atrial fibrillation (AF) increases energy demand in atrial myocytes, yet the mitochondrial mechanisms underlying this stress remain poorly defined. Using previously published proteomic data from left atrial tissue of AF and sham-operated goats, we performed organelle-specific bioinformatic analyses of the mitochondrial fraction. Over-representation and consensus pathway analyses consistently highlighted enrichment of oxidative phosphorylation (OXPHOS) subunits. Gene set enrichment and network analyses implicated Heat Shock Protein Family A Member 9 (HSPA9) as a potentially central regulatory hub coordinating the dysregulation of Complex I and III subunits, with 69% of regulatory relationships showing pathway concordance. These results indicate a coordinated, system-wide mitochondrial adaptation in AF, integrating energy production, proteostasis, and respiratory chain regulation. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Grant Information: | United Kingdom WT_ Wellcome Trust; MAESTRIA: 965286 European Union; 109371/Z/15/Z United Kingdom WT_ Wellcome Trust |
| Substance Nomenclature: | 0 (Proteome) |
| Entry Date(s): | Date Created: 20260618 Date Completed: 20260907 Latest Revision: 20261014 |
| Update Code: | 20261014 |
| PubMed Central ID: | PMC13550620 |
| DOI: | 10.1038/s41598-026-58413-1 |
| PMID: | 42315940 |
| Βάση Δεδομένων: | MEDLINE |
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