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Auditory cueing in spatial neglect: Effects on visual search depend on auditory spatial performance.

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Τίτλος: Auditory cueing in spatial neglect: Effects on visual search depend on auditory spatial performance.
Συγγραφείς: Bongartz CLJ; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland. Electronic address: clara.bongartz@unilu.ch., Kaufmann BC; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: brigitte.kaufmann@unilu.ch., Paladini RE; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: rebecca.paladini@gmail.com., Bauer D; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: daniel.bauer@luks.ch., Frey J; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: julia.frey@hin.ch., Nef T; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: tobias.nef@unibe.ch., Schumacher R; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: rahel.schumacher@luks.ch., Nyffeler T; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland; Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland; Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. Electronic address: thomas.nyffeler@luks.ch., Cazzoli D; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: dario.cazzoli@unilu.ch.
Πηγή: Neuropsychologia [Neuropsychologia] 2026 Sep 09; Vol. 230, pp. 109532. Date of Electronic Publication: 2026 Jun 18.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Pergamon Press Country of Publication: England NLM ID: 0020713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3514 (Electronic) Linking ISSN: 00283932 NLM ISO Abbreviation: Neuropsychologia Subsets: MEDLINE
Imprint Name(s): Publication: Oxford : Pergamon Press
Original Publication: Oxford.
Ιατρικοί όροι (MeSH): Perceptual Disorders*/physiopathology , Perceptual Disorders*/diagnostic imaging , Perceptual Disorders*/etiology , Space Perception*/physiology , Visual Perception*/physiology , Sound Localization*/physiology , Auditory Perception*/physiology , Cues*, Stroke/complications ; Stroke/diagnostic imaging ; Stroke/physiopathology ; Humans ; Male ; Female ; Aged ; Middle Aged ; Magnetic Resonance Imaging ; Acoustic Stimulation ; Functional Laterality ; Brain Mapping
Περίληψη: Research on spatial neglect predominantly focuses on the visual domain, often conceptualising cross-modal spatial cueing as a potential means to ameliorate visuospatial performance. As spatial neglect can affect multiple sensory modalities, it is unclear how patients with different profiles (e.g., those with visual neglect only versus those with additional auditory neglect) respond to these cues. This study thus investigated the effects of cross-modal spatial cueing in spatial neglect, considering the role of auditory spatial impairment. A total of 60 participants were included, comprising 40 right-hemispheric stroke patients presenting with (V+) or without (V-) visual neglect and 20 healthy controls. Based on the performance in an auditory spatial localisation task, V+ patients were subdivided into those with visual neglect only (V + A-) and those with additional auditory neglect (V + A+). Participants completed a visual search task comprising four cueing conditions: congruent, incongruent, mono sound (i.e., a binaural tone with no spatial properties), and no sound. Voxel-based lesion-symptom mapping (VLSM) was conducted to identify neural correlates of impaired auditory localisation. Critically, only V + A- patients benefited from congruent auditory cues, whereas V+A+ patients did not. Across participants, higher auditory localisation accuracy significantly correlated with faster search durations in the congruent condition. VLSM revealed that poorer auditory localisation performance was associated with lesions involving the first and second branches of the right superior longitudinal fasciculus. These findings suggest that the efficacy of auditory cueing in spatial neglect depends on the sensory modalities affected, necessitating multimodal assessments to devise individualised rehabilitation strategies.
(Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest.
Contributed Indexing: Keywords: Auditory localisation; Cross-modal cueing; Spatial neglect; Stroke; Superior longitudinal fasciculus; Supramodal processing; Voxel-based lesion-symptom mapping
Entry Date(s): Date Created: 20260618 Date Completed: 20260718 Latest Revision: 20260718
Update Code: 20260719
DOI: 10.1016/j.neuropsychologia.2026.109532
PMID: 42314985
Βάση Δεδομένων: MEDLINE
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  Data: Auditory cueing in spatial neglect: Effects on visual search depend on auditory spatial performance.
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  Data: <searchLink fieldCode="AU" term="%22Bongartz+CLJ%22">Bongartz CLJ</searchLink>; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland. Electronic address: clara.bongartz@unilu.ch.<br /><searchLink fieldCode="AU" term="%22Kaufmann+BC%22">Kaufmann BC</searchLink>; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: brigitte.kaufmann@unilu.ch.<br /><searchLink fieldCode="AU" term="%22Paladini+RE%22">Paladini RE</searchLink>; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: rebecca.paladini@gmail.com.<br /><searchLink fieldCode="AU" term="%22Bauer+D%22">Bauer D</searchLink>; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: daniel.bauer@luks.ch.<br /><searchLink fieldCode="AU" term="%22Frey+J%22">Frey J</searchLink>; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: julia.frey@hin.ch.<br /><searchLink fieldCode="AU" term="%22Nef+T%22">Nef T</searchLink>; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: tobias.nef@unibe.ch.<br /><searchLink fieldCode="AU" term="%22Schumacher+R%22">Schumacher R</searchLink>; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland. Electronic address: rahel.schumacher@luks.ch.<br /><searchLink fieldCode="AU" term="%22Nyffeler+T%22">Nyffeler T</searchLink>; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland; Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland; Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. Electronic address: thomas.nyffeler@luks.ch.<br /><searchLink fieldCode="AU" term="%22Cazzoli+D%22">Cazzoli D</searchLink>; Faculty of Behavioural Sciences and Psychology, University of Lucerne, Lucerne, Switzerland; Neurocenter, Lucerne Cantonal Hospital LUKS, University Teaching and Research Hospital, Lucerne, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. Electronic address: dario.cazzoli@unilu.ch.
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  Data: Research on spatial neglect predominantly focuses on the visual domain, often conceptualising cross-modal spatial cueing as a potential means to ameliorate visuospatial performance. As spatial neglect can affect multiple sensory modalities, it is unclear how patients with different profiles (e.g., those with visual neglect only versus those with additional auditory neglect) respond to these cues. This study thus investigated the effects of cross-modal spatial cueing in spatial neglect, considering the role of auditory spatial impairment. A total of 60 participants were included, comprising 40 right-hemispheric stroke patients presenting with (V+) or without (V-) visual neglect and 20 healthy controls. Based on the performance in an auditory spatial localisation task, V+ patients were subdivided into those with visual neglect only (V + A-) and those with additional auditory neglect (V + A+). Participants completed a visual search task comprising four cueing conditions: congruent, incongruent, mono sound (i.e., a binaural tone with no spatial properties), and no sound. Voxel-based lesion-symptom mapping (VLSM) was conducted to identify neural correlates of impaired auditory localisation. Critically, only V + A- patients benefited from congruent auditory cues, whereas V+A+ patients did not. Across participants, higher auditory localisation accuracy significantly correlated with faster search durations in the congruent condition. VLSM revealed that poorer auditory localisation performance was associated with lesions involving the first and second branches of the right superior longitudinal fasciculus. These findings suggest that the efficacy of auditory cueing in spatial neglect depends on the sensory modalities affected, necessitating multimodal assessments to devise individualised rehabilitation strategies.<br /> (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no conflict of interest.
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  Data: <i>Keywords: </i>Auditory localisation; Cross-modal cueing; Spatial neglect; Stroke; Superior longitudinal fasciculus; Supramodal processing; Voxel-based lesion-symptom mapping
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