Academic Journal
Male factor infertility diagnoses, but not male age, significantly affect the yield of usable embryos in donor oocyte cycles.
| Τίτλος: | Male factor infertility diagnoses, but not male age, significantly affect the yield of usable embryos in donor oocyte cycles. |
|---|---|
| Συγγραφείς: | Chemerinski A; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address: ac2059@njms.rutgers.edu., Ibrahim M; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey., Ocon V; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey., Saad-Naguib M; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey., Douglas NC; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey., Shin D; Department of Urology, Hackensack University Medical Center, Hackensack, New Jersey., Arshad M; School of Public Health, Rutgers Health, New Brunswick, New Jersey., Greenberg P; School of Public Health, Rutgers Health, New Brunswick, New Jersey., McGovern PG; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey., Morelli SS; Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey. |
| Πηγή: | Fertility and sterility [Fertil Steril] 2026 Oct; Vol. 126 (4), pp. 640-647. Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine Original Publication: New York, Hoeber. |
| Ιατρικοί όροι (MeSH): | Infertility, Male*/diagnosis , Infertility, Male*/physiopathology , Infertility, Male*/therapy , Oocyte Donation*/trends , Embryo Transfer* , Preimplantation Diagnosis* , Fertilization in Vitro* , Paternal Age*, Humans ; Male ; Female ; Pregnancy ; Adult ; Age Factors ; Middle Aged ; Aneuploidy |
| Περίληψη: | Objective: To evaluate the impact of male age and male factor infertility on embryo suitability for transfer in in vitro fertilization cycles in which female factor is controlled. Design: The national Society for Assisted Reproductive Technology Clinic Outcome Reporting System cycle data were used to evaluate the impact of male age and male factor infertility diagnosis on embryo suitability for transfer in cycles using nonidentified donor oocytes. Male age was primarily analyzed as a categorical variable (<30, 30-39, 40-49, and ≥50 years). Subjects: All in vitro fertilization cycles using nonidentified donor oocytes with preimplantation genetic testing for aneuploidy between 2017 and 2022 were included. Exposure: Male age and male factor diagnosis. Main Outcome Measures: Number of embryos biopsied for preimplantation genetic testing for aneuploidy and number of embryos suitable for transfer. Results: The median number of embryos biopsied per cycle and the median number of embryos suitable for transfer did not differ across male age groups. When comparing all cycles with and without male factor infertility, regardless of age, there was a similar number of embryos biopsied per cycle (5 [3,8] vs. 5 [3,8]), but a higher median number of embryos suitable for transfer (4 [2,6] vs. 3 [2,5]) in the cycles with no male factor diagnoses. When examining outcomes by specific male factor diagnoses, no differences were seen in the number of embryos biopsied or the number suitable for transfer. Conclusion: Together, these data suggest that although male age does not significantly impact embryo suitability for transfer, the presence of any male factor diagnoses does decrease the number of embryos available for transfer. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of Interests A.C. has nothing to disclose. M.I. has nothing to disclose. V.O. has nothing to disclose. M.S.N. has nothing to disclose. N.C.D has nothing to disclose. D.S. is Director-At-Large for the Society for Male Reproduction, Urology Chair for the Urology Care Foundation Reproductive and Sexual Health Committee, and holds equity in Fellow Health. M.A. reports NIH Award Number UM1TR004789 (New Jersey Alliance for Clinical and Translational Science) supports some of the hourly effort for the Rutgers University Biostatistics & Epidemiology Services Center (RUBIES) student and full-time employees to provide statistical services for clinical and translational research projects. P.G. reports NIH Award Number UM1TR004789 (New Jersey Alliance for Clinical and Translational Science) supports some of the hourly effort for the Rutgers University Biostatistics & Epidemiology Services Center (RUBIES) student and full-time employees to provide statistical services for clinical and translational research projects. P.G.M. is the site investigator for the IBSA PROGRESS Trial (NCT04549116) and the site investigator for May Health Rebalance Device Trial (CR003). S.S.M. is Academic Director-at-Large for the Society for Reproductive Endocrinology and Infertility. |
| Contributed Indexing: | Keywords: Male age; embryo quality; male factor infertility |
| Entry Date(s): | Date Created: 20260617 Date Completed: 20260925 Latest Revision: 20260925 |
| Update Code: | 20260926 |
| DOI: | 10.1016/j.fertnstert.2026.06.023 |
| PMID: | 42309215 |
| Βάση Δεδομένων: | MEDLINE |
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