Academic Journal
Caregiver COVID-19 vaccine status and its influence on pediatric vaccination decisions in a US cohort.
| Τίτλος: | Caregiver COVID-19 vaccine status and its influence on pediatric vaccination decisions in a US cohort. |
|---|---|
| Συγγραφείς: | Ricke IJ; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, United States of America. Electronic address: ricke201@umn.edu., Ward C; Division of Biostatistics & Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN 55454, United States of America., Spaulding AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Sherwood NE; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, United States of America., Nguyen RHN; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, United States of America. |
| Πηγή: | Vaccine [Vaccine] 2026 Aug 13; Vol. 88, pp. 128847. Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam, The Netherlands : Elsevier Science Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983- |
| Ιατρικοί όροι (MeSH): | Caregivers*/psychology , COVID-19 Vaccines*/administration & dosage , COVID-19*/prevention & control , COVID-19*/epidemiology , Vaccination*/psychology , Vaccination*/statistics & numerical data , Vaccination Hesitancy*/psychology , Vaccination Hesitancy*/statistics & numerical data , Vaccination Refusal*/psychology , Vaccination Refusal*/statistics & numerical data, United States/epidemiology ; SARS-CoV-2/immunology ; Humans ; Male ; Female ; Child, Preschool ; Child ; Cohort Studies ; Infant ; Unvaccinated Persons ; Adult ; Adolescent |
| Περίληψη: | Background/objectives: Despite availability of safe and effective COVID-19 vaccines for children, uptake of this vaccine remains low in the United States. Caregiver attitudes and behaviors play a key role in child vaccine decisions, yet little is known about the reasons for vaccine refusal within families or the relationship between COVID-19 vaccine and routine childhood immunization refusal. This study examined 1) associations between caregiver and child COVID-19 vaccination status, 2) alignment of reasons for vaccine non-acceptance between the caregiver themselves and for their child, and 3) associations between COVID-19 vaccine non-acceptance and refusal or delay of routine childhood vaccinations. Methods: We analyzed data from 6395 families in the NIH ECHO Cohort with self-reported caregiver and child COVID-19 vaccination status between December 2021 and August 2023. Generalized estimating equations were used to assess associations while accounting for cohort clustering. Results: Of the 6395 families, 25% of caregivers had not accepted the COVID-19 vaccine for themselves, and 59% had not accepted the vaccine for any of their children. Children were more likely to be unvaccinated when their caregivers were unvaccinated (OR: 13.2, 95% CI: 10.3-16.9). Among unvaccinated caregiver-child pairs, reasons for vaccine refusal showed strong concordance. The predominant concern among vaccinated caregivers with unvaccinated children was a belief that the COVID-19 vaccine had not been well tested in children (OR: 3.7, 95% CI: 2.3-6.0). Caregivers who refused the COVID-19 vaccination for themselves were more likely to have delayed or refused routine vaccines for their child (child unvaccinated for COVID-19: OR: 1.8, 95% CI: 1.4-2.1); caregiver unvaccinated for COVID-19: OR 2.8, 95% CI: 2.2-3.4). Conclusions: COVID-19 vaccine status among caregivers was strongly associated with child COVID-19 vaccine uptake and broader vaccine behaviors. Addressing shared safety concerns and building caregiver trust in vaccines is essential for improving pediatric vaccination coverage. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Grant Information: | U24 OD023382 United States OD NIH HHS |
| Contributed Indexing: | Keywords: COVID-19 vaccine; Pediatric vaccines; Vaccine refusal; Vaccine uptake |
| Substance Nomenclature: | 0 (COVID-19 Vaccines) |
| Entry Date(s): | Date Created: 20260617 Date Completed: 20260811 Latest Revision: 20260919 |
| Update Code: | 20260919 |
| DOI: | 10.1016/j.vaccine.2026.128847 |
| PMID: | 42308977 |
| Βάση Δεδομένων: | MEDLINE |
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