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Influence of crude extracts from different thermally treated Hysterothylacium thalassini L3 larvae on liver pathology and immune responses in C57BL/6 mice.

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Τίτλος: Influence of crude extracts from different thermally treated Hysterothylacium thalassini L3 larvae on liver pathology and immune responses in C57BL/6 mice.
Συγγραφείς: Abdel-Gaber R; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia., Alotaibi M; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia., Albeshr M; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia., Dkhil MA; Department of Zoology and Entomology, Faculty of Science, https://ror.org/00h55v928Capital University (formerly Helwan University), Cairo, Egypt., Santourlidis S; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, https://ror.org/024z2rq82Heinrich-Heine-Universitat Düsseldorf, Düsseldorf, Germany., Elghamdy AO; Faculty of Arts and Science, https://ror.org/0403jak37Al-Baha University, Al-Baha Province, Saudi Arabia., Al-Quraishy S; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia., Al-Shaebi EM; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.
Πηγή: Journal of helminthology [J Helminthol] 2026 Jun 15; Vol. 100, pp. e64. Date of Electronic Publication: 2026 Jun 15.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: London School Of Hygiene And Tropical Medicine Country of Publication: England NLM ID: 2985115R Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2697 (Electronic) Linking ISSN: 0022149X NLM ISO Abbreviation: J Helminthol Subsets: MEDLINE
Imprint Name(s): Publication: London : London School Of Hygiene And Tropical Medicine
Original Publication: London [etc.]
Ιατρικοί όροι (MeSH): Liver*/pathology , Liver*/drug effects , Liver*/immunology , Ascaridoidea*/chemistry , Complex Mixtures*/pharmacology, Larva/chemistry ; Oxidative Stress/drug effects ; Animals ; Male ; Mice, Inbred C57BL ; Mice ; Hot Temperature
Περίληψη: Hysterothylacium thalassini third-stage larvae (L3), commonly found in marine fish, are known to induce liver injury, oxidative stress, and immune disturbances when transmitted to mammalian hosts. This study investigated the pathological effects of purified crude extracts derived from fresh, heat-treated, and frozen L3 larvae on liver function, oxidative status, and immune responses in a murine model. Thirty Saurida tumbil fish were examined for L3 larvae, which were processed under three conditions: fresh (24 ± 2 °C for 60 min), heat-treated (100 °C for 60 min), and frozen (-20 °C for 24 h). Twenty male C57BL/6 mice were randomly allocated into four groups and inoculated with larval extracts at a 14-day interval. Mice exposed to fresh larval extracts exhibited significant weight loss, elevated liver enzymes (ALT, AST, ALP), hyperglycemia, and reduced total protein levels, alongside severe hepatic damage characterized by necrosis and inflammatory infiltration. Antioxidant enzyme activities (CAT and SOD) were markedly decreased, whereas oxidative stress markers (NO and H₂O₂) were increased. Additionally, there was significant upregulation of iNOS, TNF-α, and IL-10 gene expression, accompanied by elevated iNOS, IL-10, and IgE protein levels, indicating strong inflammatory and Th2-type immune responses. In contrast, extracts from heat-treated and frozen larvae resulted in attenuated pathological effects, including improved liver function, reduced oxidative stress, and moderated immune responses. These findings demonstrate that untreated L3 larval extracts exert pronounced hepatotoxic and immunomodulatory effects, while thermal and freezing treatments significantly reduce their pathogenicity and support immune homeostasis, highlighting potential strategies to mitigate parasite-induced host damage.
Σχόλια: Erratum in: J Helminthol. 2026 Sep 21;100:e119. doi: 10.1017/S0022149X26102284.. (PMID: 42764779)
Contributed Indexing: Keywords: Hysterothylacium thalassini; Saurida tumbil; immune modulation; liver injury; oxidative stress
Substance Nomenclature: 0 (Complex Mixtures)
Entry Date(s): Date Created: 20260615 Date Completed: 20260615 Latest Revision: 20260921
Update Code: 20260921
DOI: 10.1017/S0022149X26101497
PMID: 42290263
Βάση Δεδομένων: MEDLINE
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  Group: Ti
  Data: Influence of crude extracts from different thermally treated Hysterothylacium thalassini L3 larvae on liver pathology and immune responses in C57BL/6 mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Abdel-Gaber+R%22">Abdel-Gaber R</searchLink>; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alotaibi+M%22">Alotaibi M</searchLink>; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Albeshr+M%22">Albeshr M</searchLink>; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Dkhil+MA%22">Dkhil MA</searchLink>; Department of Zoology and Entomology, Faculty of Science, https://ror.org/00h55v928Capital University (formerly Helwan University), Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Santourlidis+S%22">Santourlidis S</searchLink>; Epigenetics Core Laboratory, Institute of Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, https://ror.org/024z2rq82Heinrich-Heine-Universitat Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Elghamdy+AO%22">Elghamdy AO</searchLink>; Faculty of Arts and Science, https://ror.org/0403jak37Al-Baha University, Al-Baha Province, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Quraishy+S%22">Al-Quraishy S</searchLink>; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Shaebi+EM%22">Al-Shaebi EM</searchLink>; Department of Zoology, College of Science, https://ror.org/02f81g417King Saud University, P.O. 2455, Riyadh 11451, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%222985115R%22">Journal of helminthology</searchLink> [J Helminthol] 2026 Jun 15; Vol. 100, pp. e64. <i>Date of Electronic Publication: </i>2026 Jun 15.
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  Data: English
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22London+School+Of+Hygiene+And+Tropical+Medicine%22">London School Of Hygiene And Tropical Medicine </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985115R <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2697 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220022149X%22">0022149X </searchLink><i>NLM ISO Abbreviation: </i>J Helminthol <i>Subsets: </i>MEDLINE
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  Label: Imprint Name(s)
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  Data: <i>Publication</i>: London : London School Of Hygiene And Tropical Medicine<br /><i>Original Publication</i>: London [etc.]
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Liver%22">Liver*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Liver%22">Liver*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Liver%22">Liver*</searchLink>/<searchLink fieldCode="MM" term="%22Liver+immunology%22">immunology</searchLink> <br /><searchLink fieldCode="MM" term="%22Ascaridoidea%22">Ascaridoidea*</searchLink>/<searchLink fieldCode="MM" term="%22Ascaridoidea+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Complex+Mixtures%22">Complex Mixtures*</searchLink>/<searchLink fieldCode="MM" term="%22Complex+Mixtures+pharmacology%22">pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Larva%22">Larva</searchLink>/<searchLink fieldCode="MH" term="%22Larva+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Oxidative+Stress%22">Oxidative Stress</searchLink>/<searchLink fieldCode="MH" term="%22Oxidative+Stress+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%2C+Inbred+C57BL%22">Mice, Inbred C57BL</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Hot+Temperature%22">Hot Temperature</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Hysterothylacium thalassini third-stage larvae (L3), commonly found in marine fish, are known to induce liver injury, oxidative stress, and immune disturbances when transmitted to mammalian hosts. This study investigated the pathological effects of purified crude extracts derived from fresh, heat-treated, and frozen L3 larvae on liver function, oxidative status, and immune responses in a murine model. Thirty Saurida tumbil fish were examined for L3 larvae, which were processed under three conditions: fresh (24 ± 2 °C for 60 min), heat-treated (100 °C for 60 min), and frozen (-20 °C for 24 h). Twenty male C57BL/6 mice were randomly allocated into four groups and inoculated with larval extracts at a 14-day interval. Mice exposed to fresh larval extracts exhibited significant weight loss, elevated liver enzymes (ALT, AST, ALP), hyperglycemia, and reduced total protein levels, alongside severe hepatic damage characterized by necrosis and inflammatory infiltration. Antioxidant enzyme activities (CAT and SOD) were markedly decreased, whereas oxidative stress markers (NO and H₂O₂) were increased. Additionally, there was significant upregulation of iNOS, TNF-α, and IL-10 gene expression, accompanied by elevated iNOS, IL-10, and IgE protein levels, indicating strong inflammatory and Th2-type immune responses. In contrast, extracts from heat-treated and frozen larvae resulted in attenuated pathological effects, including improved liver function, reduced oxidative stress, and moderated immune responses. These findings demonstrate that untreated L3 larval extracts exert pronounced hepatotoxic and immunomodulatory effects, while thermal and freezing treatments significantly reduce their pathogenicity and support immune homeostasis, highlighting potential strategies to mitigate parasite-induced host damage.
– Name: Comment
  Label: Comments
  Group: Commnt
  Data: Erratum in: J Helminthol. 2026 Sep 21;100:e119. doi: 10.1017/S0022149X26102284.. (PMID: <searchLink fieldCode="PM" term="%2242764779%22">42764779)</searchLink>
– Name: SubjectMinor
  Label: Contributed Indexing
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  Data: <i>Keywords: </i>Hysterothylacium thalassini; Saurida tumbil; immune modulation; liver injury; oxidative stress
– Name: NumberCAS
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  Data: 0 (Complex Mixtures)
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  Label: Entry Date(s)
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  Data: <i>Date Created: </i>20260615 <i>Date Completed: </i>20260615 <i>Latest Revision: </i>20260921
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  Label: Update Code
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  Data: 20260921
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  Data: 10.1017/S0022149X26101497
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  Data: 42290263
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42290263
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        Value: 10.1017/S0022149X26101497
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e64
    Subjects:
      – SubjectFull: Larva chemistry
        Type: general
      – SubjectFull: Oxidative Stress drug effects
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Mice, Inbred C57BL
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      – SubjectFull: Mice
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      – SubjectFull: Hot Temperature
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      – SubjectFull: Liver pathology
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      – SubjectFull: Liver drug effects
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      – SubjectFull: Liver immunology
        Type: general
      – SubjectFull: Ascaridoidea chemistry
        Type: general
      – SubjectFull: Complex Mixtures pharmacology
        Type: general
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      – TitleFull: Influence of crude extracts from different thermally treated Hysterothylacium thalassini L3 larvae on liver pathology and immune responses in C57BL/6 mice.
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              Text: 2026 Jun 15
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              Y: 2026
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