Academic Journal
Clinical Phenomenology of Bipolar Disorder With Substance Use Disorders: A Systematic Review.
| Τίτλος: | Clinical Phenomenology of Bipolar Disorder With Substance Use Disorders: A Systematic Review. |
|---|---|
| Συγγραφείς: | Garvie S; Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Sorkhou M; Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., George TP; Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. |
| Πηγή: | Bipolar disorders [Bipolar Disord] 2026 Aug; Vol. 28 (5), pp. e70132. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Munksgaard Country of Publication: Denmark NLM ID: 100883596 Publication Model: Print Cited Medium: Internet ISSN: 1399-5618 (Electronic) Linking ISSN: 13985647 NLM ISO Abbreviation: Bipolar Disord Subsets: MEDLINE |
| Imprint Name(s): | Publication: Copenhagen : Wiley-Blackwell Munksgaard Original Publication: Copenhagen, Denmark : Munksgaard, 1999- |
| Ιατρικοί όροι (MeSH): | Bipolar Disorder*/epidemiology , Bipolar Disorder*/complications , Bipolar Disorder*/therapy , Substance-Related Disorders*/epidemiology , Substance-Related Disorders*/complications, Humans |
| Περίληψη: | Objectives: Bipolar disorder (BD) frequently co-occurs with substance use disorders (SUDs), including alcohol, cannabis, tobacco, stimulants, and opioids. Comorbid SUDs can worsen the clinical presentation of BD, contributing to more severe mood episodes, rapid cycling, and poorer recovery outcomes. However, the unique impacts of different SUDs on the BD clinical profile are less studied, potentially obscuring substance-specific effects on the course of illness and prognosis in BD. Methods: We conducted a systematic review of the literature (PubMed, PsycINFO) and identified N = 48 clinical studies exploring the clinical effects of specific SUDs on BD symptomatology, course of illness, and treatment outcomes. Results: Our findings revealed that cannabis use disorder (CUD) and alcohol use disorder (AUD) are the most studied SUDs in BD. Concurrent CUD is frequently associated with increased manic episodes, rapid cycling, psychosis, and earlier BD onset, with mixed findings for depressive episodes, suicidality, and treatment outcomes. AUD is frequently linked with worse depression outcomes and increased suicidality, with mixed findings for manic symptoms, rapid cycling, age of onset, psychosis, and treatment outcomes. Other SUDs, including cocaine, tobacco, opioids, and methamphetamine, were underexplored but were linked to increased suicidality, hospitalizations, and medication nonadherence. Conclusions: Specific clinical profiles were associated with different SUDs, which underscores the need for more research to improve our understanding and treatment of comorbid BD-SUDs. Further research exploring non-alcohol and non-cannabis SUDs and utilizing more rigorous methodological designs is needed to clearly elucidate these associations and advance substance-specific interventions in BD patients. (© 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| References: | I. Grande, M. Berk, B. Birmaher, and E. Vieta, “Bipolar Disorder,” Lancet 387, no. 10027 (2016): 1561–1572, https://doi.org/10.1016/S0140‐6736(15)00241‐X. A. Jain and P. Mitra, “Bipolar Disorder,” in StatPearls (StatPearls Publishing, 2024), http://www.ncbi.nlm.nih.gov/books/NBK558998/. J. Alonso, M. Petukhova, G. Vilagut, et al., “Days Out of Role due to Common Physical and Mental Conditions: Results From the WHO World Mental Health Surveys,” Molecular Psychiatry 16, no. 12 (2011): 1234–1246, https://doi.org/10.1038/mp.2010.101. A. S. Coles, J. Sasiadek, and T. P. George, “Pharmacotherapies for Co‐Occurring Substance Use and Bipolar Disorders: A Systematic Review,” Bipolar Disorders 21, no. 7 (2019): 595–610, https://doi.org/10.1111/bdi.12794. D. A. Regier, M. E. Farmer, D. S. Rae, et al., “Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse. Results From the Epidemiologic Catchment Area (ECA) Study,” Journal of the American Medical Association 264, no. 19 (1990): 2511–2518. I. M. Salloum and E. S. Brown, “Management of Comorbid Bipolar Disorder and Substance Use Disorders,” American Journal of Drug and Alcohol Abuse 43, no. 4 (2017): 366–376, https://doi.org/10.1080/00952990.2017.1292279. G. E. Hunt, G. S. Malhi, M. Cleary, H. M. X. Lai, and T. Sitharthan, “Prevalence of Comorbid Bipolar and Substance Use Disorders in Clinical Settings, 1990–2015: Systematic Review and Meta‐Analysis,” Journal of Affective Disorders 206 (2016): 331–349, https://doi.org/10.1016/j.jad.2016.07.011. A. C. Swann, D. M. Dougherty, P. J. Pazzaglia, M. Pham, and F. G. Moeller, “Impulsivity: A Link Between Bipolar Disorder and Substance Abuse,” Bipolar Disorders 6, no. 3 (2004): 204–212, https://doi.org/10.1111/j.1399‐5618.2004.00110.x. T. V. Lagerberg, S. R. Aminoff, M. Aas, et al., “Alcohol Use Disorders Are Associated With Increased Affective Lability in Bipolar Disorder,” Journal of Affective Disorders 208 (2017): 316–324, https://doi.org/10.1016/j.jad.2016.09.062. C. F. Baldassano, “Illness Course, Comorbidity, Gender, and Suicidality in Patients With Bipolar Disorder,” Journal of Clinical Psychiatry 67, no. Suppl 11 (2006): 8–11. T. Messer, G. Lammers, F. Müller‐Siecheneder, R. F. Schmidt, and S. Latifi, “Substance Abuse in Patients With Bipolar Disorder: A Systematic Review and Meta‐Analysis,” Psychiatry Research 253 (2017): 338–350, https://doi.org/10.1016/j.psychres.2017.02.067. E. J. Dalton, T. D. Cate‐Carter, E. Mundo, S. V. Parikh, and J. L. Kennedy, “Suicide Risk in Bipolar Patients: The Role of Co‐Morbid Substance Use Disorders,” Bipolar Disorders 5, no. 1 (2003): 58–61, https://doi.org/10.1034/j.1399‐5618.2003.00017.x. B. I. Goldstein, M. A. Strober, B. Birmaher, et al., “Substance Use Disorders Among Adolescents With Bipolar Spectrum Disorders,” Bipolar Disorders 10, no. 4 (2008): 469–478, https://doi.org/10.1111/j.1399‐5618.2008.00584.x. J. B. Potash, H. S. Kane, Y. F. Chiu, et al., “Attempted Suicide and Alcoholism in Bipolar Disorder: Clinical and Familial Relationships,” American Journal of Psychiatry 157, no. 12 (2000): 2048–2050, https://doi.org/10.1176/appi.ajp.157.12.2048. K. Gao, D. E. Kemp, Z. Wang, et al., “Predictors of Non‐Stabilization During the Combination Therapy of Lithium and Divalproex in Rapid Cycling Bipolar Disorder: A Post‐Hoc Analysis of Two Studies,” Psychopharmacology Bulletin 43, no. 1 (2010): 23–38. A. Kenneson, J. S. Funderburk, and S. A. Maisto, “Substance Use Disorders Increase the Odds of Subsequent Mood Disorders,” Drug and Alcohol Dependence 133, no. 2 (2013): 338–343, https://doi.org/10.1016/j.drugalcdep.2013.06.011. P. H. Steinbuchel, T. E. Wilens, J. J. Adamson, and S. Sgambati, “Posttraumatic Stress Disorder and Substance Use Disorder in Adolescent Bipolar Disorder,” Bipolar Disorders 11, no. 2 (2009): 198–204, https://doi.org/10.1111/j.1399‐5618.2008.00652.x. K. T. Brady and S. C. Sonne, “The Relationship Between Substance Abuse and Bipolar Disorder,” Journal of Clinical Psychiatry 56, no. Suppl 3 (1995): 19–24. M. J. Ostacher, R. H. Perlis, A. A. Nierenberg, et al., “Impact of Substance Use Disorders on Recovery From Episodes of Depression in Bipolar Disorder Patients: Prospective Data From the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP‐BD),” American Journal of Psychiatry 167, no. 3 (2010): 289–297, https://doi.org/10.1176/appi.ajp.2009.09020299. S. H. Sperry, A. R. Stromberg, V. A. Murphy, et al., “Longitudinal Interplay Between Alcohol Use, Mood, and Functioning in Bipolar Spectrum Disorders,” JAMA Network Open 7, no. 6 (2024): e2415295, https://doi.org/10.1001/jamanetworkopen.2024.15295. M. Kato, N. Adachi, Y. Kubota, et al., “Clinical Features Related to Rapid Cycling and One‐Year Euthymia in Bipolar Disorder Patients: A Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Clinics (MUSUBI),” Journal of Psychiatric Research 131 (2020): 228–234, https://doi.org/10.1016/j.jpsychires.2020.09.030. S. Lev‐Ran, B. Le Foll, K. McKenzie, T. P. George, and J. Rehm, “Bipolar Disorder and Co‐Occurring Cannabis Use Disorders: Characteristics, Co‐Morbidities and Clinical Correlates,” Psychiatry Research 209, no. 3 (2013): 459–465, https://doi.org/10.1016/j.psychres.2012.12.014. M. Aas, B. Etain, F. Bellivier, et al., “Additive Effects of Childhood Abuse and Cannabis Abuse on Clinical Expressions of Bipolar Disorders,” Psychological Medicine 44, no. 8 (2014): 1653–1662, https://doi.org/10.1017/S0033291713002316. J. V. Bizzarri, A. Sbrana, P. Rucci, et al., “The Spectrum of Substance Abuse in Bipolar Disorder: Reasons for Use, Sensation Seeking and Substance Sensitivity,” Bipolar Disorders 9, no. 3 (2007): 213–220, https://doi.org/10.1111/j.1399‐5618.2007.00383.x. I. Maremmani, A. G. I. Maremmani, F. Rugani, et al., “Clinical Presentations of Substance Abuse in Bipolar Heroin Addicts at Time of Treatment Entry,” Annals of General Psychiatry 11, no. 1 (2012): 23, https://doi.org/10.1186/1744‐859X‐11‐23. S. B. Quello, K. T. Brady, and S. C. Sonne, “Mood Disorders and Substance Use Disorder: A Complex Comorbidity,” Science & Practice Perspectives 3, no. 1 (2005): 13–21, https://doi.org/10.1151/spp053113. L. H. Reich, R. K. Davies, and J. M. Himmelhoch, “Excessive Alcohol Use in Manic‐Depressive Illness,” American Journal of Psychiatry 131, no. 1 (1974): 83–86, https://doi.org/10.1176/ajp.131.1.83. J. F. Goldberg, J. L. Garno, A. M. Callahan, D. L. Kearns, B. Kerner, and S. H. Ackerman, “Overdiagnosis of Bipolar Disorder Among Substance Use Disorder Inpatients With Mood Instability,” Journal of Clinical Psychiatry 69, no. 11 (2008): 1751–1757, https://doi.org/10.4088/jcp.v69n1110. C. Stewart and R. S. El‐Mallakh, “Is Bipolar Disorder Overdiagnosed Among Patients With Substance Abuse?,” Bipolar Disorders 9, no. 6 (2007): 646–648, https://doi.org/10.1111/j.1399‐5618.2007.00465.x. M. J. Albanese, R. C. J. Clodfelter, T. B. Pardo, and S. N. Ghaemi, “Underdiagnosis of Bipolar Disorder in Men With Substance Use Disorder,” Journal of Psychiatric Practice 12, no. 2 (2006): 124–127. U. W. Preuss, M. Schaefer, C. Born, and H. Grunze, “Bipolar Disorder and Comorbid Use of Illicit Substances,” Medicina (Mexico City, Mexico) 57, no. 11 (2021): 1256, https://doi.org/10.3390/medicina57111256. J. Peterson, V. Welch, M. Losos, and P. Tugwell, The Newcastle‐Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta‐Analyses (Ottawa Hospital Research Institute, 2011). D. Ducasse, I. Jaussent, S. Guillaume, et al., “Increased Risk of Suicide Attempt in Bipolar Patients With Severe Tobacco Dependence,” Journal of Affective Disorders 183 (2015): 113–118, https://doi.org/10.1016/j.jad.2015.04.038. J. F. Goldberg, J. L. Garno, A. C. Leon, J. H. Kocsis, and L. Portera, “A History of Substance Abuse Complicates Remission From Acute Mania in Bipolar Disorder,” Journal of Clinical Psychiatry 60, no. 11 (1999): 733–740, https://doi.org/10.4088/jcp.v60n1103. J. F. Goldberg, J. L. Garno, L. Portera, A. C. Leon, J. H. Kocsis, and J. E. Whiteside, “Correlates of Suicidal Ideation in Dysphoric Mania,” Journal of Affective Disorders 56, no. 1 (1999): 75–81, https://doi.org/10.1016/s0165‐0327(99)00025‐7. I. M. Salloum, J. R. Cornelius, J. E. Mezzich, and L. Kirisci, “Impact of Concurrent Alcohol Misuse on Symptom Presentation of Acute Mania at Initial Evaluation,” Bipolar Disorders 4, no. 6 (2002): 418–421, https://doi.org/10.1034/j.1399‐5618.2002.01194.x. S. Singh, L. Forty, A. di Florio, et al., “Affective Temperaments and Concomitant Alcohol Use Disorders in Bipolar Disorder,” Journal of Affective Disorders 186 (2015): 226–231, https://doi.org/10.1016/j.jad.2015.07.027. T. V. Lagerberg, R. Icick, O. A. Andreassen, et al., “Cannabis Use Disorder Is Associated With Greater Illness Severity in Tobacco Smoking Patients With Bipolar Disorder,” Journal of Affective Disorders 190 (2016): 286–293, https://doi.org/10.1016/j.jad.2015.10.023. C. Baethge, R. J. Baldessarini, H. M. K. Khalsa, J. Hennen, P. Salvatore, and M. Tohen, “Substance Abuse in First‐Episode Bipolar I Disorder: Indications for Early Intervention,” American Journal of Psychiatry 162, no. 5 (2005): 1008–1010, https://doi.org/10.1176/appi.ajp.162.5.1008. C. Baethge, J. Hennen, H. M. K. Khalsa, P. Salvatore, M. Tohen, and R. J. Baldessarini, “Sequencing of Substance Use and Affective Morbidity in 166 First‐Episode Bipolar I Disorder Patients,” Bipolar Disorders 10, no. 6 (2008): 738–741, https://doi.org/10.1111/j.1399‐5618.2007.00575.x. T. V. Lagerberg, R. Icick, S. R. Aminoff, et al., “Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder,” Frontiers in Psychiatry 12 (2021): 656912, https://doi.org/10.3389/fpsyt.2021.656912. S. M. Strakowski, M. P. DelBello, D. E. Fleck, and S. Arndt, “The Impact of Substance Abuse on the Course of Bipolar Disorder,” Biological Psychiatry 48, no. 6 (2000): 477–485, https://doi.org/10.1016/S0006‐3223(00)00900‐8. S. M. Strakowski, M. P. DelBello, D. E. Fleck, et al., “Effects of Co‐Occurring Cannabis Use Disorders on the Course of Bipolar Disorder After a First Hospitalization for Mania,” Archives of General Psychiatry 64, no. 1 (2007): 57–64, https://doi.org/10.1001/archpsyc.64.1.57. R. S. Patel, Z. Cheema, A. Singla, M. Cornejo, and G. Verma, “Cannabis Use Is an Independent Risk Factor for Manic Episode: A Report From 380,265 Bipolar Inpatients,” Substance Use & Misuse 57, no. 3 (2022): 344–349, https://doi.org/10.1080/10826084.2021.2012690. L. M. Weinstock, B. A. Gaudiano, S. J. Wenze, G. Epstein‐Lubow, and I. W. Miller, “Demographic and Clinical Characteristics Associated With Comorbid Cannabis Use Disorders (CUDs) in Hospitalized Patients With Bipolar I Disorder,” Comprehensive Psychiatry 65 (2016): 57–62, https://doi.org/10.1016/j.comppsych.2015.10.003. R. J. Braga, K. E. Burdick, P. Derosse, and A. K. Malhotra, “Cognitive and Clinical Outcomes Associated With Cannabis Use in Patients With Bipolar I Disorder,” Psychiatry Research 200, no. 2–3 (2012): 242–245, https://doi.org/10.1016/j.psychres.2012.05.025. F. Cassidy, “Risk Factors of Attempted Suicide in Bipolar Disorder,” Suicide & Life‐Threatening Behavior 41, no. 1 (2011): 6–11, https://doi.org/10.1111/j.1943‐278X.2010.00007.x. R. Icick, I. Melle, B. Etain, et al., “Tobacco Smoking and Other Substance Use Disorders Associated With Recurrent Suicide Attempts in Bipolar Disorder,” Journal of Affective Disorders 256 (2019): 348–357, https://doi.org/10.1016/j.jad.2019.05.075. T. V. Lagerberg, K. Sundet, S. R. Aminoff, et al., “Excessive Cannabis Use Is Associated With Earlier Age at Onset in Bipolar Disorder,” European Archives of Psychiatry and Clinical Neuroscience 261, no. 6 (2011): 397–405, https://doi.org/10.1007/s00406‐011‐0188‐4. A. F. Oladunjoye, S. Z. Kaleem, A. Suresh, et al., “Cannabis Use and Medication Nonadherence in Bipolar Disorder: A Nationwide Inpatient Sample Database Analysis,” Journal of Affective Disorders 299 (2022): 174–179, https://doi.org/10.1016/j.jad.2021.11.067. B. M. Cardoso, M. Kauer Sant'Anna, V. V. Dias, A. C. Andreazza, K. M. Ceresér, and F. Kapczinski, “The Impact of Co‐Morbid Alcohol Use Disorder in Bipolar Patients,” Alcohol 42, no. 6 (2008): 451–457, https://doi.org/10.1016/j.alcohol.2008.05.003. R. Icick, S. Gard, K. M'Bailara, et al., “The Course of Bipolar Disorder as a Function of the Presence and Sequence of Onset of Comorbid Alcohol Use Disorders in Outpatients Attending the Fondamental Advanced Centres of Expertise,” Journal of Affective Disorders 287 (2021): 196–203, https://doi.org/10.1016/j.jad.2021.03.041. D. Janiri, M. Di Nicola, G. Martinotti, and L. Janiri, “Who's the Leader, Mania or Depression? Predominant Polarity and Alcohol/Polysubstance Use in Bipolar Disorders,” Current Neuropharmacology 15, no. 3 (2017): 409–416, https://doi.org/10.2174/1570159X14666160607101400. M. A. Oquendo, D. Currier, S. M. Liu, D. S. Hasin, B. F. Grant, and C. Blanco, “Increased Risk for Suicidal Behavior in Comorbid Bipolar Disorder and Alcohol Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC),” Journal of Clinical Psychiatry 71, no. 7 (2010): 902–909, https://doi.org/10.4088/JCP.09m05198gry. Y. Xia, D. Ma, T. Perich, J. Hu, and P. B. Mitchell, “Demographic and Clinical Differences Between Bipolar Disorder Patients With and Without Alcohol Use Disorders,” Frontiers in Psychiatry 11 (2020): 8, https://doi.org/10.3389/fpsyt.2020.570574. W. A. Nolen, D. A. Luckenbaugh, L. L. Altshuler, et al., “Correlates of 1‐Year Prospective Outcome in Bipolar Disorder: Results From the Stanley Foundation Bipolar Network,” American Journal of Psychiatry 161, no. 8 (2004): 1447–1454, https://doi.org/10.1176/appi.ajp.161.8.1447. R. H. Perlis, M. J. Ostacher, J. F. Goldberg, et al., “Transition to Mania During Treatment of Bipolar Depression,” Neuropsychopharmacology 35, no. 13 (2010): 2545–2552, https://doi.org/10.1038/npp.2010.122. C. Simhandl, J. Radua, B. König, and B. L. Amann, “Prevalence and Impact of Comorbid Alcohol Use Disorder in Bipolar Disorder: A Prospective Follow‐Up Study,” Australian and New Zealand Journal of Psychiatry 50, no. 4 (2016): 345–351, https://doi.org/10.1177/0004867415585855. S. M. Strakowski, M. P. DelBello, D. E. Fleck, et al., “Effects of Co‐Occurring Alcohol Abuse on the Course of Bipolar Disorder Following a First Hospitalization for Mania,” Archives of General Psychiatry 62, no. 8 (2005): 851–858, https://doi.org/10.1001/archpsyc.62.8.851. J. van Zaane, W. van den Brink, S. Draisma, J. H. Smit, and W. A. Nolen, “The Effect of Moderate and Excessive Alcohol Use on the Course and Outcome of Patients With Bipolar Disorders: A Prospective Cohort Study,” Journal of Clinical Psychiatry 71, no. 7 (2010): 885–893, https://doi.org/10.4088/JCP.09m05079gry. A. C. Swann, F. G. Moeller, J. L. Steinberg, L. Schneider, E. S. Barratt, and D. M. Dougherty, “Manic Symptoms and Impulsivity During Bipolar Depressive Episodes,” Bipolar Disorders 9, no. 3 (2007): 206–212, https://doi.org/10.1111/j.1399‐5618.2007.00357.x. U. W. Preuss, M. N. Hesselbrock, and V. M. Hesselbrock, “A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset,” Frontiers in Psychiatry 11 (2020): 10, https://doi.org/10.3389/fpsyt.2020.522228. M. A. Oquendo, C. Waternaux, B. Brodsky, et al., “Suicidal Behavior in Bipolar Mood Disorder: Clinical Characteristics of Attempters and Nonattempters,” Journal of Affective Disorders 59, no. 2 (2000): 107–117, https://doi.org/10.1016/S0165‐0327(99)00129‐9. H. C. Tang, P. H. Chen, K. H. Chung, C. J. Kuo, S. H. Huang, and S. Y. Tsai, “Psychological Outcomes and Medical Morbidity of Patients With Bipolar Disorder and Co‐Occurring Alcohol Use Disorder,” Journal of Dual Diagnosis 11, no. 3–4 (2015): 184–188, https://doi.org/10.1080/15504263.2015.1113099. H. A. Yee, H. S. Loh, and C. G. Ng, “The Prevalence and Correlates of Alcohol Use Disorder Amongst Bipolar Patients in a Hospital Setting, Malaysia,” International Journal of Psychiatry in Clinical Practice 17, no. 4 (2013): 292–297, https://doi.org/10.3109/13651501.2012.752012. Y. H. Yoon, C. M. Chen, H. y. Yi, and H. B. Moss, “Effect of Comorbid Alcohol and Drug Use Disorders on Premature Death Among Unipolar and Bipolar Disorder Decedents in the United States, 1999 to 2006,” Comprehensive Psychiatry 52, no. 5 (2011): 453–464, https://doi.org/10.1016/j.comppsych.2010.10.005. S. Suttajit, S. Paholpak, S. Choovanicvong, K. Kittiwattanagul, W. Pratoomsri, and M. Srisurapanont, “Correlates of Current Suicide Risk Among Thai Patients With Bipolar I Disorder: Findings From the Thai Bipolar Disorder Registry,” Neuropsychiatric Disease and Treatment 9 (2013): 7, https://doi.org/10.2147/NDT.S52519. S. Y. Tsai, C. C. Chen, and E. K. Yeh, “Alcohol Problems and Long‐Term Psychosocial Outcome in Chinese Patients With Bipolar Disorder,” Journal of Affective Disorders 46, no. 2 (1997): 143–150, https://doi.org/10.1016/S0165‐0327(97)00099‐2. S. M. Strakowski, S. L. McElroy, P. E. Keck, and S. A. West, “The Effects of Antecedent Substance Abuse on the Development of First‐Episode Psychotic Mania,” Journal of Psychiatric Research 30, no. 1 (1996): 59–68, https://doi.org/10.1016/0022‐3956(95)00044‐5. E. Levander, M. A. Frye, S. McElroy, et al., “Alcoholism and Anxiety in Bipolar Illness: Differential Lifetime Anxiety Comorbidity in Bipolar I Women With and Without Alcoholism,” Journal of Affective Disorders 101, no. 1–3 (2007): 211–217, https://doi.org/10.1016/j.jad.2006.11.023. B. I. Goldstein and A. J. Levitt, “A Gender‐Focused Perspective on Health Service Utilization in Comorbid Bipolar I Disorder and Alcohol Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions,” Journal of Clinical Psychiatry 67, no. 6 (2006): 925–932, https://doi.org/10.4088/JCP.v67n0609. R. H. Perlis, M. J. Ostacher, D. J. Miklowitz, et al., “Clinical Features Associated With Poor Pharmacologic Adherence in Bipolar Disorder: Results From the STEP‐BD Study,” Journal of Clinical Psychiatry 71, no. 3 (2010): 296–303, https://doi.org/10.4088/JCP.09m05514yel. M. Lalli, K. Brouillette, F. Kapczinski, and T. de Azevedo Cardoso, “Substance Use as a Risk Factor for Bipolar Disorder: A Systematic Review,” Journal of Psychiatric Research 144 (2021): 285–295, https://doi.org/10.1016/j.jpsychires.2021.10.012. M. J. Ostacher, “Bipolar and Substance Use Disorder Comorbidity: Diagnostic and Treatment Considerations,” Focus 9, no. 4 (2011): 428–434, https://doi.org/10.1176/foc.9.4.foc428. G. Maggu, S. Choudhary, R. Jaishy, S. Chaudhury, D. Saldanha, and M. Borasi, “Cannabis Use and Its Relationship With Bipolar Disorder: A Systematic Review and Meta‐Analysis,” Industrial Psychiatry Journal 32, no. 2 (2023): 202–214, https://doi.org/10.4103/ipj.ipj_43_23. R. P. Murray, J. E. Connett, P. Mäkelä, and J. Rehm, “Difficulty in Demonstrating a Risk From Drinking Pattern in Fourteen Years of Coronary Heart Disease Morbidity and Mortality: The Lung Health Study,” Addictive Behaviors 30, no. 5 (2005): 875–887, https://doi.org/10.1016/j.addbeh.2004.08.028. D. C. D'Souza, W. M. Abi‐Saab, S. Madonick, et al., “Delta‐9‐Tetrahydrocannabinol Effects in Schizophrenia: Implications for Cognition, Psychosis, and Addiction,” Biological Psychiatry 57, no. 6 (2005): 594–608, https://doi.org/10.1016/j.biopsych.2004.12.006. M. Gibbs, C. Winsper, S. Marwaha, E. Gilbert, M. Broome, and S. P. Singh, “Cannabis Use and Mania Symptoms: A Systematic Review and Meta‐Analysis,” Journal of Affective Disorders 171 (2015): 39–47, https://doi.org/10.1016/j.jad.2014.09.016. C. Henquet, L. Krabbendam, R. de Graaf, M. ten Have, and J. van Os, “Cannabis Use and Expression of Mania in the General Population,” Journal of Affective Disorders 95, no. 1–3 (2006): 103–110, https://doi.org/10.1016/j.jad.2006.05.002. M. Sorkhou, E. L. Dent, and T. P. George, “Cannabis Use and Mood Disorders: A Systematic Review,” Frontiers in Public Health 12 (2024): 1346207, https://doi.org/10.3389/fpubh.2024.1346207. J. Hirvonen, R. S. Goodwin, C. T. Li, et al., “Reversible and Regionally Selective Downregulation of Brain Cannabinoid CB1 Receptors in Chronic Daily Cannabis Smokers,” Molecular Psychiatry 17, no. 6 (2012): 642–649, https://doi.org/10.1038/mp.2011.82. R. A. Rabin and T. P. George, “A Review of Co‐Morbid Tobacco and Cannabis Use Disorders: Possible Mechanisms to Explain High Rates of Co‐Use,” American Journal on Addictions 24, no. 2 (2015): 105–116, https://doi.org/10.1111/ajad.12186. A. D. Kendall, D. Hedeker, K. R. Diviak, and R. J. Mermelstein, “The Mood Boost From Tobacco Cigarettes Is More Erratic With the Additions of Cannabis and Alcohol,” Nicotine & Tobacco Research 24, no. 8 (2022): 1169–1176, https://doi.org/10.1093/ntr/ntac001. J. V. Pinto, L. S. Medeiros, G. Santana da Rosa, et al., “The Prevalence and Clinical Correlates of Cannabis Use and Cannabis Use Disorder Among Patients With Bipolar Disorder: A Systematic Review With Meta‐Analysis and Meta‐Regression,” Neuroscience and Biobehavioral Reviews 101 (2019): 78–84, https://doi.org/10.1016/j.neubiorev.2019.04.004. C. Joslyn, D. J. Hawes, C. Hunt, and P. B. Mitchell, “Is Age of Onset Associated With Severity, Prognosis, and Clinical Features in Bipolar Disorder? A Meta‐Analytic Review,” Bipolar Disorders 18, no. 5 (2016): 389–403, https://doi.org/10.1111/bdi.12419. J. Jacobus and S. F. Tapert, “Effects of Cannabis on the Adolescent Brain,” Current Pharmaceutical Design 20, no. 13 (2014): 2186–2193. M. Di Nicola, L. Moccia, V. R. Ferri, I. Panaccione, and L. Janiri, “Alcoholism in Bipolar Disorders: An Overview of Epidemiology, Common Pathogenetic Pathways, Course of Disease, and Implications for Treatment,” In Neuroscience of Alcohol: Mechanisms and Treatment (Academic Press, 2019), 363–371, https://doi.org/10.1016/B978‐0‐12‐813125‐1.00038‐6. T. D. Meyer, J. L. McDonald, J. L. Douglas, and J. Scott, “Do Patients With Bipolar Disorder Drink Alcohol for Different Reasons When Depressed, Manic or Euthymic?,” Journal of Affective Disorders 136, no. 3 (2012): 926–932, https://doi.org/10.1016/j.jad.2011.09.005. J. N. Miller and D. W. Black, “Bipolar Disorder and Suicide: A Review,” Current Psychiatry Reports 22, no. 2 (2020): 6, https://doi.org/10.1007/s11920‐020‐1130‐0. M. E. Sublette, J. J. Carballo, C. Moreno, et al., “Substance Use Disorders and Suicide Attempts in Bipolar Subtypes,” Journal of Psychiatric Research 43, no. 3 (2009): 230–238, https://doi.org/10.1016/j.jpsychires.2008.05.001. M. R. Hufford, “Alcohol and Suicidal Behavior,” Clinical Psychology Review 21, no. 5 (2001): 797–811, https://doi.org/10.1016/s0272‐7358(00)00070‐2. J. M. Cerimele, A. M. Bauer, J. C. Fortney, and M. S. Bauer, “Patients With co‐Occurring Bipolar Disorder and Posttraumatic Stress Disorder: A Rapid Review of the Literature,” Journal of Clinical Psychiatry 78, no. 5 (2017): e506–e514, https://doi.org/10.4088/JCP.16r10897. M. K. Reddy, T. D. Meyer, N. M. Wittlin, I. W. Miller, and L. M. Weinstock, “Bipolar I Disorder With Comorbid PTSD: Demographic and Clinical Correlates in a Sample of Hospitalized Patients,” Comprehensive Psychiatry 72 (2017): 13–17, https://doi.org/10.1016/j.comppsych.2016.08.007. R. Holliday, L. M. Borges, K. A. Stearns‐Yoder, A. S. Hoffberg, L. A. Brenner, and L. L. Monteith, “Posttraumatic Stress Disorder, Suicidal Ideation, and Suicidal Self‐Directed Violence Among U.S. Military Personnel and Veterans: A Systematic Review of the Literature From 2010 to 2018,” Frontiers in Psychology 11 (2020): 1998, https://doi.org/10.3389/fpsyg.2020.01998. A. F. Carvalho, R. S. McIntyre, D. Dimelis, et al., “Predominant Polarity as a Course Specifier for Bipolar Disorder: A Systematic Review,” Journal of Affective Disorders 163 (2014): 56–64, https://doi.org/10.1016/j.jad.2014.03.035. J. J. Rakofsky and B. W. Dunlop, “Do Alcohol Use Disorders Destabilize the Course of Bipolar Disorder?,” Journal of Affective Disorders 145, no. 1 (2013): 1–10, https://doi.org/10.1016/j.jad.2012.06.012. L. N. Yatham, “Diagnosis and Management of Patients With Bipolar II Disorder,” Journal of Clinical Psychiatry 66, no. Suppl 1 (2005): 13–17. G. M. MacQueen and L. T. Young, “Bipolar II Disorder: Symptoms, Course, and Response to Treatment,” Psychiatric Services 52, no. 3 (2001): 358–361, https://doi.org/10.1176/appi.ps.52.3.358. L. L. Judd, P. J. Schettler, H. S. Akiskal, et al., “Long‐Term Symptomatic Status of Bipolar I vs. Bipolar II Disorders,” International Journal of Neuropsychopharmacology 6, no. 2 (2003): 127–137, https://doi.org/10.1017/S1461145703003341. I. Jawad, S. Watson, P. M. Haddad, P. S. Talbot, and R. H. McAllister‐Williams, “Medication Nonadherence in Bipolar Disorder: A Narrative Review,” Therapeutic Advances in Psychopharmacology 8, no. 12 (2018): 349–363, https://doi.org/10.1177/2045125318804364. |
| Contributed Indexing: | Keywords: alcohol; bipolar disorders; cannabis; cocaine; depression; mania; mood disorders; substance dependence; substance‐related disorders; tobacco |
| Entry Date(s): | Date Created: 20260613 Date Completed: 20260613 Latest Revision: 20260616 |
| Update Code: | 20260617 |
| DOI: | 10.1111/bdi.70132 |
| PMID: | 42286971 |
| Βάση Δεδομένων: | MEDLINE |
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