Academic Journal
Concurrent Photobiomodulation by Dual-Wavelength (655 nm and 808 nm) Laser Exposure Promotes Accelerated Wound Healing.
| Τίτλος: | Concurrent Photobiomodulation by Dual-Wavelength (655 nm and 808 nm) Laser Exposure Promotes Accelerated Wound Healing. |
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| Συγγραφείς: | Sirek B; Department of Biomedical Sciences, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Izmir, Türkiye.; Department of Biomedical Engineering, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, Türkiye., Bozoğlu A; Department of Biomedical Engineering, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, Türkiye., Topaloğlu N; Department of Biomedical Engineering, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, Türkiye. |
| Πηγή: | Photobiomodulation, photomedicine, and laser surgery [Photobiomodul Photomed Laser Surg] 2026 Aug; Vol. 44 (8), pp. 468-474. Date of Electronic Publication: 2026 Jun 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101734781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2578-5478 (Electronic) Linking ISSN: 25785478 NLM ISO Abbreviation: Photobiomodul Photomed Laser Surg Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [New Rochelle, NY] : Mary Ann Liebert, Inc., [2019]- |
| Ιατρικοί όροι (MeSH): | Wound Healing*/radiation effects , Low-Level Light Therapy*/methods, Reactive Oxygen Species/metabolism ; Cell Movement/radiation effects ; Cell Survival/radiation effects ; Animals ; Red Light ; Humans |
| Περίληψη: | Background: Photobiomodulation (PBM) is a noninvasive light therapy that penetrates deeper skin layers, using wavelengths such as near-infrared. Different wavelengths target specific cellular components and pathways, influencing wound healing. Light absorption by both mitochondria and light-sensitive ion channels increases intracellular reactive oxygen species (ROS) levels, thereby affecting inflammation, platelet activation, angiogenesis, tissue remodeling, and cell viability. Concurrent use of multiple wavelengths has an advantage, activating distinct pathways involved in the wound-healing process. Purpose: This in vitro study aimed to investigate the effects of concurrent PBM on fibrablasts using a dual-wavelength system (655 nm and 808 nm). The effects of concurrent PBM application at three energy densities on cell viability, intracellular ROS levels, and cell migration were assessed using two modalities: single- and triple-treatment protocols. Methods: Three different energy densities (0.5, 1, and 2 J/cm2) of a dual wavelength system were used, and applications were performed using single or triple applications. Cellular responses were evaluated by assessing viability, ROS generation, and migration. Results: Concurrent PBM application at an energy density of 1 J/cm2 showed a synergistic effect, increasing cell viability by 3%, intracellular ROS levels by 20%, and accelerating wound closure by 89% compared with the untreated group. Conclusion: Concurrent dual-wavelength PBM application may reduce treatment duration and enhance wound healing, offering a promising approach for targeting multiple layers and substructures of complex biological tissue in in vivo models and clinical applications. |
| Contributed Indexing: | Keywords: cell migration; concurrent photobiomodulation; dual-wavelength; near-infrared light; reactive oxygen species; red light; wound healing |
| Substance Nomenclature: | 0 (Reactive Oxygen Species) |
| Entry Date(s): | Date Created: 20260612 Date Completed: 20260707 Latest Revision: 20260707 |
| Update Code: | 20260708 |
| DOI: | 10.1177/25785478261460632 |
| PMID: | 42286424 |
| Βάση Δεδομένων: | MEDLINE |
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