Academic Journal
Synthesis, biological profiling, and computational investigation of 1,2,4-triazole-5-thione-quinoline Schiff base hybrids.
| Τίτλος: | Synthesis, biological profiling, and computational investigation of 1,2,4-triazole-5-thione-quinoline Schiff base hybrids. |
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| Συγγραφείς: | Gültekin E; Science-Technology Research and Application Center, Artvin Coruh University, Artvin, Turkiye., Doğan H; Scientific, Technical, Application and Research Center, Hitit University, Çorum, Turkiye., Atalay A; Department of Nutrition and Dietetics, Faculty of Health Science, Avrasya University, Trabzon, Turkiye., Canbolat Gültekin D; Medicinal-Aromatic Plants Application and Research Center, Artvin Coruh University, Artvin, Turkiye.; Department of Medical Biochemistry, Institute of Health Sciences, Karadeniz Technical University, Trabzon, Turkiye., Özkan Aİ; Medicinal-Aromatic Plants Application and Research Center, Artvin Coruh University, Artvin, Turkiye. |
| Πηγή: | Future medicinal chemistry [Future Med Chem] 2026 Jul; Vol. 18 (14), pp. 1871-1886. Date of Electronic Publication: 2026 Jun 12. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Milton Park, Oxfordshire] : Taylor & Francis Original Publication: London : Future Science, 2009- |
| Ιατρικοί όροι (MeSH): | Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , Urease*/antagonists & inhibitors , Urease*/metabolism , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Quinolines*/chemistry , Quinolines*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Thiones*/chemistry , Thiones*/pharmacology , Thiones*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/chemistry , Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry, Schiff Bases/chemistry ; Schiff Bases/pharmacology ; Schiff Bases/chemical synthesis ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Biphenyl Compounds/antagonists & inhibitors ; Molecular Docking Simulation ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Density Functional Theory ; Molecular Structure |
| Περίληψη: | Aims: To synthesize novel 1,2,4-triazole-5-thione-quinoline Schiff base hybrids and evaluate their urease inhibitory, antimicrobial, antioxidant, and computational properties. Materials and Methods: Two series of compounds, 7(a-d) and 8(a-d), were synthesized and structurally characterized by Fourier Transform-Infrared (FT-IR), 1 H/13C Nuclear Magnetic Resonance (NMR), mass spectrometry, and elemental analysis. Urease inhibition was determined spectrophotometrically. Antimicrobial activity was assessed by disc diffusion and broth microdilution methods. Antioxidant activity was evaluated using ferric-reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Density functional theory (DFT) and molecular docking studies were also performed. Results and Conclusions: Compounds 7c and 8c showed the strongest urease inhibitory activity, each with an IC |
| Contributed Indexing: | Keywords: Antimicrobial activity; DFT; antioxidant activity; molecular docking; quinoline; triazole-5-thione; urease inhibition |
| Substance Nomenclature: | 0 (Schiff Bases) 0 (Triazoles) EC 3.5.1.5 (Urease) 0 (Antioxidants) 0 (Quinolines) 288-88-0 (1,2,4-triazole) 0 (Anti-Bacterial Agents) 0 (Thiones) 0 (Enzyme Inhibitors) 0 (Antifungal Agents) E66400VT9R (quinoline) 0 (Anti-Infective Agents) 0 (Biphenyl Compounds) |
| Entry Date(s): | Date Created: 20260612 Date Completed: 20260703 Latest Revision: 20260706 |
| Update Code: | 20260707 |
| DOI: | 10.1080/17568919.2026.2684452 |
| PMID: | 42283163 |
| Βάση Δεδομένων: | MEDLINE |
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