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Fontan Failure in Adult Patients: From Physiology to Solutions.

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Τίτλος: Fontan Failure in Adult Patients: From Physiology to Solutions.
Συγγραφείς: Karev EA; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation., Stovpyuk OF; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation., Alekseeva DV; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation., Malishevskaya DS; International Heart Center, Saint Petersburg, Russian Federation., Malishevsky LM; Tomsk National Research Medical Center of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation., Avramenko AA; Federal State Budgetary Educational Institution of Higher Education, 'Samara State Medical University' of the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation.
Πηγή: World journal for pediatric & congenital heart surgery [World J Pediatr Congenit Heart Surg] 2026 Nov; Vol. 17 (6), pp. 821-833. Date of Electronic Publication: 2026 Jun 11.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Sage Publications Country of Publication: United States NLM ID: 101518415 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-136X (Electronic) Linking ISSN: 21501351 NLM ISO Abbreviation: World J Pediatr Congenit Heart Surg Subsets: MEDLINE
Imprint Name(s): Original Publication: Thousand Oaks, CA : Sage Publications
Ιατρικοί όροι (MeSH): Fontan Procedure*/adverse effects , Heart Defects, Congenital*/surgery , Heart Defects, Congenital*/physiopathology , Heart Failure*/etiology , Heart Failure*/physiopathology , Postoperative Complications*/physiopathology, Humans ; Adult ; Treatment Failure
Περίληψη: The adult population with congenital heart defects of varying complexity is growing rapidly. This includes a significant number of patients over the age of 18 who underwent surgery in early childhood to correct conotruncal anomalies and septal defects. While patients with a functional single ventricle palliated with the Fontan procedure are still relatively rare in developing countries, the expertise gained from managing these patients in expert centers in Europe and the United States of America, as well as the success of pediatric cardiac surgery, has drawn increasing attention to this subject. In this review article, we aim to discuss the unique pathophysiology of Fontan circulation and clinical issues in the management of adult patients, with a particular focus on identifying specific predictors of heart failure decompensation and potential complications in this population.
Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Contributed Indexing: Keywords: Fontan circulation; adult congenital heart disease; cardiac transplant; heart failure; lymphatic complications
Entry Date(s): Date Created: 20260611 Date Completed: 20260930 Latest Revision: 20260930
Update Code: 20260930
DOI: 10.1177/21501351261443997
PMID: 42272421
Βάση Δεδομένων: MEDLINE
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  Data: Fontan Failure in Adult Patients: From Physiology to Solutions.
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  Data: <searchLink fieldCode="AU" term="%22Karev+EA%22">Karev EA</searchLink>; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Stovpyuk+OF%22">Stovpyuk OF</searchLink>; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Alekseeva+DV%22">Alekseeva DV</searchLink>; Functional Diagnostics, Federal State Budgetary Institution 'V.A. Almazov National Medical Research Center' of the Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Malishevskaya+DS%22">Malishevskaya DS</searchLink>; International Heart Center, Saint Petersburg, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Malishevsky+LM%22">Malishevsky LM</searchLink>; Tomsk National Research Medical Center of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation.<br /><searchLink fieldCode="AU" term="%22Avramenko+AA%22">Avramenko AA</searchLink>; Federal State Budgetary Educational Institution of Higher Education, 'Samara State Medical University' of the Ministry of Healthcare of the Russian Federation, Samara, Russian Federation.
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  Data: <searchLink fieldCode="JN" term="%22101518415%22">World journal for pediatric & congenital heart surgery</searchLink> [World J Pediatr Congenit Heart Surg] 2026 Nov; Vol. 17 (6), pp. 821-833. <i>Date of Electronic Publication: </i>2026 Jun 11.
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  Data: <i>Original Publication</i>: Thousand Oaks, CA : Sage Publications
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  Data: <searchLink fieldCode="MM" term="%22Fontan+Procedure%22">Fontan Procedure*</searchLink>/<searchLink fieldCode="MM" term="%22Fontan+Procedure+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Defects%2C+Congenital%22">Heart Defects, Congenital*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Defects%2C+Congenital+surgery%22">surgery</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Defects%2C+Congenital%22">Heart Defects, Congenital*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Defects%2C+Congenital+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Postoperative+Complications%22">Postoperative Complications*</searchLink>/<searchLink fieldCode="MM" term="%22Postoperative+Complications+physiopathology%22">physiopathology</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Treatment+Failure%22">Treatment Failure</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The adult population with congenital heart defects of varying complexity is growing rapidly. This includes a significant number of patients over the age of 18 who underwent surgery in early childhood to correct conotruncal anomalies and septal defects. While patients with a functional single ventricle palliated with the Fontan procedure are still relatively rare in developing countries, the expertise gained from managing these patients in expert centers in Europe and the United States of America, as well as the success of pediatric cardiac surgery, has drawn increasing attention to this subject. In this review article, we aim to discuss the unique pathophysiology of Fontan circulation and clinical issues in the management of adult patients, with a particular focus on identifying specific predictors of heart failure decompensation and potential complications in this population.
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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  Label: Contributed Indexing
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  Data: <i>Keywords: </i>Fontan circulation; adult congenital heart disease; cardiac transplant; heart failure; lymphatic complications
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  Data: <i>Date Created: </i>20260611 <i>Date Completed: </i>20260930 <i>Latest Revision: </i>20260930
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  Data: 10.1177/21501351261443997
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  Data: 42272421
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        Text: English
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      – SubjectFull: Treatment Failure
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      – SubjectFull: Fontan Procedure adverse effects
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      – SubjectFull: Heart Defects, Congenital surgery
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      – SubjectFull: Heart Defects, Congenital physiopathology
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      – SubjectFull: Heart Failure etiology
        Type: general
      – SubjectFull: Heart Failure physiopathology
        Type: general
      – SubjectFull: Postoperative Complications physiopathology
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      – TitleFull: Fontan Failure in Adult Patients: From Physiology to Solutions.
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              Text: 2026 Nov
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