Academic Journal
Persistence and dynamics of antibiotic resistome in a drinking water supply system with booster chlorination.
| Τίτλος: | Persistence and dynamics of antibiotic resistome in a drinking water supply system with booster chlorination. |
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| Συγγραφείς: | Lo HY; Graduate Institute of Environmental Engineering, National Taiwan University, Taiwan; Water Innovation, Low-carbon and Environmental Sustainability Research Center, College of Engineering, National Taiwan University, Taiwan., Hsiao YT; Graduate Institute of Environmental Engineering, National Taiwan University, Taiwan., Wu YJ; Department of Safety Health and Environmental Engineering, National United University, Taiwan., Whang LM; Department of Environmental Engineering, National Cheng Kung University, Taiwan., Chen WH; Dept of Water Quality, Taiwan Water Corporation, Taiwan., Tung HH; Graduate Institute of Environmental Engineering, National Taiwan University, Taiwan; Water Innovation, Low-carbon and Environmental Sustainability Research Center, College of Engineering, National Taiwan University, Taiwan. Electronic address: htung@ntu.edu.tw. |
| Πηγή: | Journal of hazardous materials [J Hazard Mater] 2026 Aug 01; Vol. 514, pp. 142622. Date of Electronic Publication: 2026 Jun 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| Ιατρικοί όροι (MeSH): | Drinking Water*/microbiology , Water Purification*/methods , Anti-Bacterial Agents*/pharmacology , Drug Resistance, Microbial*/genetics , Chlorine*/chemistry , Drug Resistance, Bacterial*/genetics, Bacteria/genetics ; Bacteria/drug effects ; Halogenation ; Water Supply ; Genes, Bacterial ; Water Microbiology |
| Περίληψη: | Due to the extensive use of antibiotics worldwide, the prevalence of antibiotic resistance genes (ARGs) in aquatic environments has become a major public health concern. This study investigated the ARGs in a drinking water supply system, with particular emphasis on booster chlorination in the distribution network. To elucidate the dynamics of the antibiotic resistome, environmental DNA was extracted from water collected from five different sections, and the resistome profiles were subsequently reconstructed with metagenome assembly. Our findings revealed that 35 core ARGs persisted but decreased in concentration during water treatment and early distribution, with genes resistant to bacitracin, multidrug, and rifamycin being the most prominent. However, a notable surge of ARGs was observed at the terminal distribution segment. This increase was linked to changes in the resistome structure, which were primarily associated with shifts in the microbial community and, within the DWDS specifically, also linked to horizontal transfer mediated by mobile genetic elements (MGEs) under chlorine stress from booster chlorination. Microbial communities within the drinking water distribution system (DWDS) shifted distinctly from those in the water treatment plant. Under re-chlorination pressure, the chlorine-tolerant Mycobacteriales and the biofilm-forming Hyphomicrobiales and Rhodobacterales became the predominant taxa. Additionally, metagenome-assembled genomes (MAGs) reconstruction further identified that Hyphomicrobium and Mycobacterium were the main ARG carriers in the DWDS, with the latter as the main putative host for the core ARGs. Overall, this study demonstrated that booster chlorination in the water distribution system while controlling microbial regrowth, may simultaneously facilitate ARG dissemination. These findings highlight the need to optimise re-chlorination practices to balance microbial growth control while minimising ARG proliferation in DWDS. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Hsin-hsin Tung reports financial support was provided by National Science and Technology Council. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antibiotic resistome; Booster chlorination; Chlorine tolerant bacteria; Drinking water distribution system; Horizontal gene transfer |
| Substance Nomenclature: | 0 (Drinking Water) 0 (Anti-Bacterial Agents) 4R7X1O2820 (Chlorine) |
| Entry Date(s): | Date Created: 20260610 Date Completed: 20260725 Latest Revision: 20260725 |
| Update Code: | 20260725 |
| DOI: | 10.1016/j.jhazmat.2026.142622 |
| PMID: | 42269300 |
| Βάση Δεδομένων: | MEDLINE |
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