Academic Journal
Positive neurological outcome after acute encephalopathy and multifocal stroke after early red blood cell exchange transfusion in a patient with hemoglobin SC sickle cell disease.
| Τίτλος: | Positive neurological outcome after acute encephalopathy and multifocal stroke after early red blood cell exchange transfusion in a patient with hemoglobin SC sickle cell disease. |
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| Συγγραφείς: | Haria E; Division of Neurocritical Care, Department of Neurology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Neurology, Texas Health Presbyterian Hospital, Dallas, Texas, USA.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Prasad S; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Romito JW; Division of Neurocritical Care, Department of Neurology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Neurology, Texas Health Presbyterian Hospital, Dallas, Texas, USA.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas, USA. |
| Πηγή: | Proceedings (Baylor University. Medical Center) [Proc (Bayl Univ Med Cent)] 2026 Jul; Vol. 39 (4), pp. 709-712. Date of Electronic Publication: 2026 Jan 14. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Baylor Research Foundation Country of Publication: United States NLM ID: 9302033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3252 (Electronic) Linking ISSN: 08998280 NLM ISO Abbreviation: Proc (Bayl Univ Med Cent) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Dallas, Tex. : Baylor Research Foundation |
| Ιατρικοί όροι (MeSH): | Erythrocyte Transfusion*/methods , Stroke*/therapy , Stroke*/etiology , Hemoglobin SC Disease*/therapy , Hemoglobin SC Disease*/complications , Brain Diseases*/therapy , Brain Diseases*/etiology , Anemia, Sickle Cell*/complications , Anemia, Sickle Cell*/therapy, Humans ; Male ; Adult ; Exchange Transfusion, Whole Blood ; Treatment Outcome |
| Περίληψη: | Sickle cell disease is a genetic disorder characterized by the presence of abnormal hemoglobin, leading to various complications, including vaso-occlusive crises and organ damage. While much research has focused on the homozygous hemoglobin SS genotype, less is known about the heterogeneous hemoglobin SC genotype (HbSC), particularly in adults. This case report details the presentation, clinical course, and management of a 27-year-old African American man with HbSC sickle cell disease, who presented with severe acute encephalopathy and multifocal acute ischemic stroke and had a positive neurological outcome due to early red blood cell exchange transfusion. The case underscores the need for vigilant clinical care considerations into the unique challenges for adults with HbSC disease. |
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| Contributed Indexing: | Keywords: HbSC sickle cell disease; neurocritical care; red blood cell exchange transfusion Local Abstract: [plain-language-summary] HbSC sickle cell disease can cause a myriad of neurological complications, including acute encephalopathy, acute ischemic stroke, hemorrhagic stroke, cerebral fat embolism, cerebral venous sinus thrombosis, moyamoya syndrome, and posterior reversible encephalopathy syndrome.Early consideration of red blood cell exchange transfusion with a goal to achieve HbS levels below 10% to 20% in patients with HbSC sickle cell disease can improve the clinical outcome in suspected sickle cell crisis. |
| Entry Date(s): | Date Created: 20260610 Date Completed: 20260613 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13271358 |
| DOI: | 10.1080/08998280.2025.2611697 |
| PMID: | 42269047 |
| Βάση Δεδομένων: | MEDLINE |
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