Academic Journal
The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells.
| Τίτλος: | The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal) |
|---|---|
| Συγγραφείς: | Zhang H; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention in Shanxi, Taiyuan, China. Electronic address: zhf201101@sxmu.edu.cn., Gao X; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention in Shanxi, Taiyuan, China., Jin Z; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention in Shanxi, Taiyuan, China., Liu Y; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, China; MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention in Shanxi, Taiyuan, China., Yin J; Department of Neurosurgery, Datong Key Laboratory of Nervous Systems Disease Prevention and Treatment for Coal Mine Workers, Shanxi Health Commission Key Laboratory of Nervous System Disease Prevention and Treatment, Sinopharm Tongmei General Hospital, Datong, Shanxi, 037003, China., Zhang R; Fifth Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: zhangrui_gc@163.com. |
| Πηγή: | Free radical biology & medicine [Free Radic Biol Med] 2026 Oct; Vol. 254, pp. 78-90. Date of Electronic Publication: 2026 Jun 09. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| Ιατρικοί όροι (MeSH): | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/metabolism , Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/genetics , Mitochondria*/drug effects , Mitochondria*/metabolism , Mitochondria*/pathology , Cellular Senescence*/drug effects , Hippocampus*/drug effects , Hippocampus*/metabolism , Hippocampus*/pathology , Hippocampus*/cytology , Neurons*/drug effects , Neurons*/metabolism , Neurons*/pathology , Pyrones*/toxicity , AMP-Activated Protein Kinases*/metabolism , AMP-Activated Protein Kinases*/genetics , Sirtuin 3*/metabolism , Sirtuin 3*/genetics , Organometallic Compounds*/toxicity, Signal Transduction/drug effects ; Isocitrate Dehydrogenase/metabolism ; Isocitrate Dehydrogenase/genetics ; Aminoimidazole Carboxamide/analogs & derivatives ; Aminoimidazole Carboxamide/pharmacology ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/genetics ; Ribonucleotides/pharmacology ; Glycolysis/drug effects ; Aluminum/toxicity ; beta-Galactosidase/metabolism ; beta-Galactosidase/genetics ; Animals ; Mice ; Superoxide Dismutase 2 ; Cell Line |
| Περίληψη: | Aluminum (Al) is a widely distributed environmental metal whose chronic exposure has been implicated in neurotoxicity and increased risk of neurodegenerative disorders. However, the molecular mechanisms linking aluminum exposure to neuronal metabolic dysfunction and senescence remain incompletely understood. In this study, mouse hippocampal neuronal HT22 cells were exposed to aluminum maltolate [Al (mal) (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: AMPK-PGC-1α-SIRT3 axis; Aluminum exposure; Environmental neurotoxicity; Mitochondrial dysfunction; Neuronal senescence |
| Substance Nomenclature: | 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) 0 (Ppargc1a protein, mouse) 0 (Pyrones) EC 2.7.11.31 (AMP-Activated Protein Kinases) EC 3.5.1.- (Sirtuin 3) EC 1.15.1.1 (Superoxide Dismutase 2) 0 (Sirt3 protein, mouse) 23058-19-7 (aluminum maltolate) EC 1.1.1.41 (Isocitrate Dehydrogenase) 0 (Organometallic Compounds) EC 1.1.1.41 (isocitrate dehydrogenase 2, mouse) 360-97-4 (Aminoimidazole Carboxamide) EC 1.15.1.1 (Superoxide Dismutase) 0 (Ribonucleotides) F0X88YW0YK (AICA ribonucleotide) CPD4NFA903 (Aluminum) EC 3.2.1.23 (beta-Galactosidase) |
| Entry Date(s): | Date Created: 20260609 Date Completed: 20260808 Latest Revision: 20260808 |
| Update Code: | 20260809 |
| DOI: | 10.1016/j.freeradbiomed.2026.06.011 |
| PMID: | 42263892 |
| Βάση Δεδομένων: | MEDLINE |
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