Academic Journal
Chemical composition, antioxidant, antifungal, antibacterial and anticancer activities of essential oils of Berberis balochistanica Ahrendt.
| Τίτλος: | Chemical composition, antioxidant, antifungal, antibacterial and anticancer activities of essential oils of Berberis balochistanica Ahrendt. |
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| Συγγραφείς: | Taj R; Department of Chemistry, University of Balochistan, Quetta, Pakistan., Ali S; Department of Chemistry, University of Balochistan, Quetta, Pakistan., Khan S; Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan., Taj N; Department of Chemistry, University of Balochistan, Quetta, Pakistan. |
| Πηγή: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2026 Aug; Vol. 39 (8), pp. 2237-2250. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 3105-9686 (Electronic) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| Ιατρικοί όροι (MeSH): | Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry , Oils, Volatile*/isolation & purification , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Antioxidants*/chemistry , Antifungal Agents*/pharmacology , Antifungal Agents*/isolation & purification , Antifungal Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/isolation & purification , Anti-Bacterial Agents*/chemistry , Berberis*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification , Antineoplastic Agents, Phytogenic*/chemistry, Alternaria/drug effects ; Microbial Sensitivity Tests ; Humans ; Gas Chromatography-Mass Spectrometry ; Cell Line, Tumor |
| Περίληψη: | Background: In Balochistan, the biotechnological potential of medicinal plants has not been widely investigated. Thus, searching medicinal plants for novel compounds is vital source for developing emerging and new medications. Objectives: The present study aims to describe the chemical profile and evaluate the antimicrobial, antioxidant and anticancer effects of the essential oil (EO) of Berberis balochistanica. Gas Chhromatography-Mass Spectrometry (GC-MS) analyzed the chemical constituents. Methods: Antioxidant potential was evaluated by 2-2-diphenyl-1-picylhydrazyl (DPPH) assay. Antifungal action was evaluated using agar well and disc diffusion methods. The antibacterial screening was evaluated against Gram-positive and Gram-negative bacterial strains through the disc diffusion technique and by determining minimal inhibitory concentration (MIC). To investigate anticancer activity, an 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay was used. Results: GC-MS analysis revealed 19 components accounting for 99.9% of the total EO. The EO exhibited a substantial effect against the fungal strain Alternaria alternate and remarkable antibacterial activity against Staphylococcus aureus, while showing no cytotoxic activity. Conclusion: These results show that B. balochastanica based EO has the potential to be evaluated in clinical applications and pharmaceutical industries as an antimicrobial agent for the treatment of various ailments. It may serve as a preservative in food stuffs, serving as a natural replacement for harmful synthetic antioxidants. |
| Contributed Indexing: | Keywords: Antimicrobial activity; Antioxidant activity; Berberis balochistanica; Essential oil composition; GC-MS; MTT |
| Substance Nomenclature: | 0 (Oils, Volatile) 0 (Antioxidants) 0 (Antifungal Agents) 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents, Phytogenic) |
| Entry Date(s): | Date Created: 20260609 Date Completed: 20260612 Latest Revision: 20260612 |
| Update Code: | 20260612 |
| DOI: | 10.36721/PJPS.2026.39.8.211.1 |
| PMID: | 42262185 |
| Βάση Δεδομένων: | MEDLINE |
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