| Συγγραφείς: |
Derar DI; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Hany F; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Eltaher H; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Mahmoud S; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Sedarous Y; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt., Ruan Z; Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou, Zhejiang, China., Alkhaldi M; The Global Health Network-The Middle East and North Africa Network (TGHN-MENA), Dubai, United Arab Emirates.; School of Health Sciences and Psychology, Department of Public Health, Canadian University Dubai, Dubai, United Arab Emirates.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; School of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada., Elhadidy M; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt.; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt.; The Global Health Network-The Middle East and North Africa Network (TGHN-MENA), Dubai, United Arab Emirates.; Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. |
| Περίληψη: |
SUMMARYAfrica's ongoing struggles with emerging epidemics and antimicrobial resistance (AMR) underscore the urgency of integrating pathogen genomics and surveillance systems into the continent's One Health strategy, particularly given the existing limitations in preparedness and technological resources. This review brings together current evidence on the growth of sequencing infrastructure, the development of regional genomic hubs, and the establishment of governance frameworks, while identifying critical challenges in data integration, bioinformatics capacity, and sustainable financing. Special focus is placed on the lack of African-based genomic data, with our analysis showing that only 1.82% of the global total is available. Case studies illustrate the immense potential and importance of pathogen genomics, giving policymakers a tangible sense of its impact. These examples demonstrate how genomic technologies integrated with artificial intelligence (AI) are transforming outbreak response, AMR surveillance, and stewardship programs by enabling early detection of zoonotic threats, mapping transmission pathways, and guiding vaccine development. However, to fully realize this scientific intel, it is essential to embed One Health pathogen surveillance within strong policy and system frameworks to ensure the translation of technical progress into lasting institutional capacity and sustainable impact. Long-term implementation depends on coordinated investment and advocacy across four interdependent pillars: data architecture, governance and sovereignty, human capital, and technical capacity. |