Academic Journal
Engineering Escherichia coli for Urease-Driven Synthesis of Metal Oxide Nanomaterials.
| Title: | Engineering Escherichia coli for Urease-Driven Synthesis of Metal Oxide Nanomaterials. |
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| Authors: | Wu ZY; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Lin AYW; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Müller IE; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Zhao Z; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Mouncey NJ; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Ercius P; The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States., Yoshikuni Y; The U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; U.S. Department of Energy Center for Bioenergy and Bioproducts Innovation (CABBI), Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.; Energy and Biosciences Institute, University of California, Berkeley, Berkeley, California 94720, United States.; Global Institution for Collaborative Research and Education, Hokkaido University, Hokkaido 060-8589, Japan. |
| Source: | ACS synthetic biology [ACS Synth Biol] 2026 Jun 19; Vol. 15 (6), pp. 2264-2273. Date of Electronic Publication: 2026 Jun 08. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, D.C. : American Chemical Society, c2012- |
| MeSH Terms: | Escherichia coli*/genetics , Escherichia coli*/metabolism , Urease*/metabolism , Urease*/genetics , Metal Nanoparticles*/chemistry , Nanostructures*/chemistry, Titanium/chemistry ; Titanium/metabolism ; Sporosarcina/genetics ; Sporosarcina/enzymology ; Ferric Compounds/chemistry ; Ferric Compounds/metabolism ; Calcium Carbonate/metabolism ; Calcium Carbonate/chemistry ; Calcium Phosphates/metabolism ; Calcium Phosphates/chemistry ; Oxides/chemistry ; Oxides/metabolism |
| Abstract: | The development of functional nanomaterials with controlled morphologies is essential for advancements in medicine, electronics and computing, energy, catalysis, and environmental applications. However, conventional synthesis methods often demand high energy input and pose significant environmental challenges. Urease-based biomineralization presents an efficient, eco-friendly alternative for nanomaterial production under mild conditions. In this study, we engineered Escherichia coli (E. coli) to express a urease gene cluster from Sporosarcina pasteurii using CRAGE-Duet technology. The engineered strain successfully synthesized calcium carbonate and calcium phosphate crystals. Expanding the approach, we synthesized metal oxide nanoparticles, including hematite (Fe |
| Contributed Indexing: | Keywords: CRAGE-Duet genome integration; engineered Escherichia coli; metal oxide nanoparticles; programmable nanomaterial synthesis; sustainable biomanufacturing; urease-mediated biomineralization |
| Substance Nomenclature: | EC 3.5.1.5 (Urease) D1JT611TNE (Titanium) 15FIX9V2JP (titanium dioxide) 0 (Ferric Compounds) 1K09F3G675 (ferric oxide) H0G9379FGK (Calcium Carbonate) 0 (Calcium Phosphates) 0 (Oxides) |
| SCR Organism: | Sporosarcina pasteurii |
| Entry Date(s): | Date Created: 20260608 Date Completed: 20260619 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13288898 |
| DOI: | 10.1021/acssynbio.5c00773 |
| PMID: | 42253114 |
| Database: | MEDLINE |
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