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Disrupted brain functional networks in adolescents and young adults with gaming disorder during social interaction: An fNIRS study.

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Τίτλος: Disrupted brain functional networks in adolescents and young adults with gaming disorder during social interaction: An fNIRS study.
Συγγραφείς: Wang Z; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China.; School of Psychology, Shanghai Jiao Tong University, Shanghai, China., Huang C; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Shan H; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Wang Y; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China.; School of Psychology, Shanghai Jiao Tong University, Shanghai, China., Li S; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China.; School of Psychology, Shanghai Jiao Tong University, Shanghai, China., Guo L; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Lyu X; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Chen Y; https://ror.org/05463eb69Hunan Railway Professional Technology College, Mental Health Education and Counseling Center, China., Zeng Y; Third Hospital of Zhuzhou, China., Su H; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Chen T; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Du J; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Jiang H; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China., Deng M; https://ror.org/0220qvk04Shanghai Jiao Tong University Antai College of Economics and Management, China., Wen X; https://ror.org/0220qvk04Shanghai Jiao Tong University Antai College of Economics and Management, China., Zhao M; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China.; Shanghai Key Laboratory of Psychotic Disorders, https://ror.org/05bd2wa15Shanghai Mental Health Center, Shanghai, China., Zhong N; Shanghai Jiao Tong University School of Medicine Affiliated Shanghai Mental Health, China.
Πηγή: Psychological medicine [Psychol Med] 2026 Jun 08; Vol. 56, pp. e189. Date of Electronic Publication: 2026 Jun 08.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE
Imprint Name(s): Publication: London : Cambridge University Press
Original Publication: London, British Medical Assn.
Ιατρικοί όροι (MeSH): Prefrontal Cortex*/physiopathology , Prefrontal Cortex*/diagnostic imaging , Internet Addiction Disorder*/physiopathology , Internet Addiction Disorder*/diagnostic imaging , Temporal Lobe*/physiopathology , Temporal Lobe*/diagnostic imaging , Parietal Lobe*/physiopathology , Parietal Lobe*/diagnostic imaging , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging , Social Interaction* , Video Games*, Humans ; Male ; Spectroscopy, Near-Infrared ; Adolescent ; Young Adult ; Adult
Περίληψη: Background: Gaming disorder (GD) is increasingly recognized for its adverse impact on social functioning, yet the underlying neural mechanisms remain unclear, particularly during real-time social interactions. This study examined neural differences in the prefrontal cortex (PFC) and temporoparietal junction (TPJ) during cooperation and competition tasks in adolescents and young adults with GD.
Methods: Using functional near-infrared spectroscopy (fNIRS), we examined 175 male participants, classified into Gaming Disorder (n = 42), Hazardous Gaming (n = 69), and Healthy Control (n = 64) groups. Participants performed cooperation and competition tasks while activation, functional connectivity, and network topology were assessed within the PFC and TPJ.
Results: In the current study, GD participants exhibited significantly greater impairments in social and emotional functioning compared to the HG and HC groups. The GD group showed increased right TPJ activation during cooperation and decreased activation during competition. Both GD and HG groups demonstrated heightened medial PFC activation and functional connectivity, indicating compensatory engagement. Graph theory analysis revealed disrupted network topology in GD, including reduced nodal efficiency and centrality within the PFC and TPJ. Neural alterations were significantly correlated with clinical measures, including gaming duration and social-emotional deficits.
Conclusion: This study identifies critical neural disruptions underlying social dysfunction in GD, particularly within mentalizing and executive control networks. The neural markers observed in the GD group have important implications for clinical diagnosis and targeted intervention, whereas similar patterns in the HG group highlight opportunities for early detection and preventive strategies.
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Grant Information: 2022ZD0211100 Shanghai Center for Brain Science and Brain-Inspired Technology; 82130041 National Natural Science Foundation of China; 82171485 National Natural Science Foundation of China; 19MC1911100 Shanghai Clinical Research Center for Mental Health; GWVI-11.2-XD26 Shanghai Municipal Health Commission
Contributed Indexing: Keywords: brain networks; functional near-infrared spectroscopy; gaming disorder; prefrontal cortex; social interaction; temporoparietal junction
Entry Date(s): Date Created: 20260608 Date Completed: 20260611 Latest Revision: 20260904
Update Code: 20260905
PubMed Central ID: PMC13247798
DOI: 10.1017/S0033291726104176
PMID: 42253034
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1469-8978
DOI:10.1017/S0033291726104176