Academic Journal
The association between thiamine use and mortality in critically ill patients with sepsis-associated acute respiratory failure: A retrospective analysis of the MIMIC-IV database.
| Τίτλος: | The association between thiamine use and mortality in critically ill patients with sepsis-associated acute respiratory failure: A retrospective analysis of the MIMIC-IV database. |
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| Συγγραφείς: | Yin M; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China., Suo X; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China., Li M; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China., He Q; Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address: 532031383@qq.com., Xu D; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China. Electronic address: 361706332@qq.com. |
| Πηγή: | Respiratory medicine [Respir Med] 2026 Aug-Sep; Vol. 260, pp. 108943. Date of Electronic Publication: 2026 Jun 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Oxford : Elsevier Original Publication: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- |
| Ιατρικοί όροι (MeSH): | Thiamine*/therapeutic use , Thiamine*/administration & dosage , Sepsis*/complications , Sepsis*/mortality , Critical Illness*/mortality , Respiratory Insufficiency*/mortality , Respiratory Insufficiency*/etiology , Respiratory Insufficiency*/drug therapy, Intensive Care Units/statistics & numerical data ; Humans ; Retrospective Studies ; Female ; Aged ; Hospital Mortality ; Male ; Middle Aged ; Databases, Factual |
| Περίληψη: | Background: Thiamine (vitamin B1) is a crucial cofactor in energy metabolism and antioxidant defense, yet its specific impact on patients with sepsis-associated acute respiratory failure remains unclear. Methods: We conducted a retrospective cohort study of 6248 sepsis-associated acute respiratory failure patients in the MIMIC-IV database (2008-2019). Patients were categorized based on thiamine supplementation. The primary endpoints were in-hospital and ICU mortality, analyzed using Kaplan-Meier curves, multivariable Cox regression, propensity score matching (PSM), and subgroup analyses. Results: The thiamine group comprised 1576 patients and the no-thiamine group 4672. After adjustment, the no thiamine group had a higher risk of hospital mortality (HR = 1.24, 95%CI 1.10-1.39) and ICU mortality (HR = 1.31, 95%CI 1.14-1.51). This protective association was confirmed in the PSM-matched cohort (n = 2784). Subgroup analysis indicated the benefit was most pronounced in patients aged ≥65 years, with no significant association observed in younger patients. Conclusion: Thiamine supplementation was independently associated with reduced in-hospital and ICU mortality in critically ill patients with sepsis-associated acute respiratory failure, particularly in the elderly.These findings support the need for randomized controlled trials to validate its potential as an adjunctive therapy. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: MIMIC-IV; Mortality; Prognosis; Sepsis-associated acute respiratory failure; Thiamine |
| Substance Nomenclature: | X66NSO3N35 (Thiamine) |
| Entry Date(s): | Date Created: 20260607 Date Completed: 20260626 Latest Revision: 20260626 |
| Update Code: | 20260626 |
| DOI: | 10.1016/j.rmed.2026.108943 |
| PMID: | 42251913 |
| Βάση Δεδομένων: | MEDLINE |
| FullText | Links: – Type: other Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4694B1380FF88959F020&Show=Object Text: Availability: 0 CustomLinks: – Url: https://www.doi.org/10.1016/j.rmed.2026.108943? Name: ScienceDirect (all content) (s7799221) Category: fullText Text: View record from ScienceDirect MouseOverText: View record from ScienceDirect |
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| Header | DbId: cmedm DbLabel: MEDLINE An: 42251913 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The association between thiamine use and mortality in critically ill patients with sepsis-associated acute respiratory failure: A retrospective analysis of the MIMIC-IV database. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yin+M%22">Yin M</searchLink>; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Suo+X%22">Suo X</searchLink>; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China.<br /><searchLink fieldCode="AU" term="%22He+Q%22">He Q</searchLink>; Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address: 532031383@qq.com.<br /><searchLink fieldCode="AU" term="%22Xu+D%22">Xu D</searchLink>; Department of Respiratory and Critical Care Medicine, Xishan People's Hospital of Wuxi City, Wuxi, China. Electronic address: 361706332@qq.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228908438%22">Respiratory medicine</searchLink> [Respir Med] 2026 Aug-Sep; Vol. 260, pp. 108943. <i>Date of Electronic Publication: </i>2026 Jun 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8908438 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3064 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209546111%22">09546111 </searchLink><i>NLM ISO Abbreviation: </i>Respir Med <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Publication</i>: 2003- : Oxford : Elsevier<br /><i>Original Publication</i>: London : Baillière Tindall, in association with the British Thoracic Society, [c1989- – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Thiamine%22">Thiamine*</searchLink>/<searchLink fieldCode="MM" term="%22Thiamine+therapeutic+use%22">therapeutic use</searchLink> <br /><searchLink fieldCode="MM" term="%22Thiamine%22">Thiamine*</searchLink>/<searchLink fieldCode="MM" term="%22Thiamine+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Sepsis%22">Sepsis*</searchLink>/<searchLink fieldCode="MM" term="%22Sepsis+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Sepsis%22">Sepsis*</searchLink>/<searchLink fieldCode="MM" term="%22Sepsis+mortality%22">mortality</searchLink> <br /><searchLink fieldCode="MM" term="%22Critical+Illness%22">Critical Illness*</searchLink>/<searchLink fieldCode="MM" term="%22Critical+Illness+mortality%22">mortality</searchLink> <br /><searchLink fieldCode="MM" term="%22Respiratory+Insufficiency%22">Respiratory Insufficiency*</searchLink>/<searchLink fieldCode="MM" term="%22Respiratory+Insufficiency+mortality%22">mortality</searchLink> <br /><searchLink fieldCode="MM" term="%22Respiratory+Insufficiency%22">Respiratory Insufficiency*</searchLink>/<searchLink fieldCode="MM" term="%22Respiratory+Insufficiency+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Respiratory+Insufficiency%22">Respiratory Insufficiency*</searchLink>/<searchLink fieldCode="MM" term="%22Respiratory+Insufficiency+drug+therapy%22">drug therapy</searchLink><br /><searchLink fieldCode="MH" term="%22Intensive+Care+Units%22">Intensive Care Units</searchLink>/<searchLink fieldCode="MH" term="%22Intensive+Care+Units+statistics+%26+numerical+data%22">statistics & numerical data</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Hospital+Mortality%22">Hospital Mortality</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Databases%2C+Factual%22">Databases, Factual</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Thiamine (vitamin B1) is a crucial cofactor in energy metabolism and antioxidant defense, yet its specific impact on patients with sepsis-associated acute respiratory failure remains unclear.<br />Methods: We conducted a retrospective cohort study of 6248 sepsis-associated acute respiratory failure patients in the MIMIC-IV database (2008-2019). Patients were categorized based on thiamine supplementation. The primary endpoints were in-hospital and ICU mortality, analyzed using Kaplan-Meier curves, multivariable Cox regression, propensity score matching (PSM), and subgroup analyses.<br />Results: The thiamine group comprised 1576 patients and the no-thiamine group 4672. After adjustment, the no thiamine group had a higher risk of hospital mortality (HR = 1.24, 95%CI 1.10-1.39) and ICU mortality (HR = 1.31, 95%CI 1.14-1.51). This protective association was confirmed in the PSM-matched cohort (n = 2784). Subgroup analysis indicated the benefit was most pronounced in patients aged ≥65 years, with no significant association observed in younger patients.<br />Conclusion: Thiamine supplementation was independently associated with reduced in-hospital and ICU mortality in critically ill patients with sepsis-associated acute respiratory failure, particularly in the elderly.These findings support the need for randomized controlled trials to validate its potential as an adjunctive therapy.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.) – Name: Abstract Label: Competing Interests Group: Ab Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>MIMIC-IV; Mortality; Prognosis; Sepsis-associated acute respiratory failure; Thiamine – Name: NumberCAS Label: Substance Nomenclature Group: ID Data: X66NSO3N35 (Thiamine) – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260607 <i>Date Completed: </i>20260626 <i>Latest Revision: </i>20260626 – Name: DateUpdate Label: Update Code Group: Date Data: 20260626 – Name: DOI Label: DOI Group: ID Data: 10.1016/j.rmed.2026.108943 – Name: AN Label: PMID Group: ID Data: 42251913 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.rmed.2026.108943 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 108943 Subjects: – SubjectFull: Intensive Care Units statistics & numerical data Type: general – SubjectFull: Humans Type: general – SubjectFull: Retrospective Studies Type: general – SubjectFull: Female Type: general – SubjectFull: Aged Type: general – SubjectFull: Hospital Mortality Type: general – SubjectFull: Male Type: general – SubjectFull: Middle Aged Type: general – SubjectFull: Databases, Factual Type: general – SubjectFull: Thiamine therapeutic use Type: general – SubjectFull: Thiamine administration & dosage Type: general – SubjectFull: Sepsis complications Type: general – SubjectFull: Sepsis mortality Type: general – SubjectFull: Critical Illness mortality Type: general – SubjectFull: Respiratory Insufficiency mortality Type: general – SubjectFull: Respiratory Insufficiency etiology Type: general – SubjectFull: Respiratory Insufficiency drug therapy Type: general Titles: – TitleFull: The association between thiamine use and mortality in critically ill patients with sepsis-associated acute respiratory failure: A retrospective analysis of the MIMIC-IV database. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yin M – PersonEntity: Name: NameFull: Suo X – PersonEntity: Name: NameFull: Li M – PersonEntity: Name: NameFull: He Q – PersonEntity: Name: NameFull: Xu D IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug-Sep Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1532-3064 Numbering: – Type: volume Value: 260 Titles: – TitleFull: Respiratory medicine Type: main |
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