Academic Journal
Evaluation of gabapentin: a 7-year review of postmortem and driving while intoxicated cases in Dallas County.
| Τίτλος: | Evaluation of gabapentin: a 7-year review of postmortem and driving while intoxicated cases in Dallas County. |
|---|---|
| Συγγραφείς: | Dempsey SK; Dallas County Southwestern Institute of Forensic Sciences, Dallas, TX 75207, United States., Glicksberg LC; Dallas County Southwestern Institute of Forensic Sciences, Dallas, TX 75207, United States. |
| Πηγή: | Journal of analytical toxicology [J Anal Toxicol] 2026 Jun 04; Vol. 50 (6). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7705085 Publication Model: Print Cited Medium: Internet ISSN: 1945-2403 (Electronic) Linking ISSN: 01464760 NLM ISO Abbreviation: J Anal Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2012- : Oxford : Oxford University Press Original Publication: 1977-<2011>: Niles, Ill., Preston Publications. |
| Ιατρικοί όροι (MeSH): | Gabapentin*/blood , Driving Under the Influence*/statistics & numerical data , Substance Abuse Detection*, Texas/epidemiology ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/blood ; Anticonvulsants/blood ; Humans ; Male ; Adult ; Middle Aged ; Forensic Toxicology ; Female ; Autopsy ; Young Adult |
| Περίληψη: | Gabapentin is an approved treatment for epilepsy and neuropathic pain but due to a relatively minimal side effect profile at therapeutic doses it is also prescribed for numerous off-label uses. Due to an increasing number of prescriptions, the misuse and abuse of gabapentin has also increased. This study reviewed driving while intoxicated (DWI) and postmortem cases positive for gabapentin submitted to the Dallas County Southwestern Institute of Forensic Sciences from January 2018 to December 2025. A total of 3189 cases were positive for gabapentin, of which 87 were DWI and 2973 were postmortem, and was identified in approximately 5% of all casework each year. Average blood concentrations were 3798.1 ng/ml (range 201.9-16 008.0 ng/ml) for DWI cases and 8983.9 ng/ml (range 200.9-180 706.2 ng/ml) for postmortem cases. The primary user of gabapentin were white males in their 40s to 50s for all case types. The substances most commonly identified with gabapentin in postmortem cases were opioids, ethanol, and stimulants and in DWI cases were stimulants, benzodiazepines, and THC and its metabolites. Almost half (47%) of postmortem cases were ruled a natural death by the medical examiner. In 155 cases (5.2%), gabapentin was included in the cause of death, most often listed with other drugs. With an increasing interest in gabapentin in forensic toxicology, the data presented indicates that gabapentin remains a consistent finding in Dallas County casework. (© The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Substance Nomenclature: | 6CW7F3G59X (Gabapentin) 0 (Anticonvulsants) |
| Entry Date(s): | Date Created: 20260606 Date Completed: 20260618 Latest Revision: 20260619 |
| Update Code: | 20260620 |
| DOI: | 10.1093/jat/bkag040 |
| PMID: | 42249549 |
| Βάση Δεδομένων: | MEDLINE |
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