Academic Journal
Effect of ESR1 and ESR2 polymorphisms on ovarian response in assisted reproductive technology cycles: a systematic review and meta-analysis.
| Τίτλος: | Effect of ESR1 and ESR2 polymorphisms on ovarian response in assisted reproductive technology cycles: a systematic review and meta-analysis. |
|---|---|
| Συγγραφείς: | Fathima KZ; Division of Reproductive Genetics, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., R VL; Centre for Digital Health, Applied Research and Technology, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Irungu S; Department of Reproductive Health and Biology, Institute of Primate Research, Nairobi, Kenya., Gupta A; Division of Reproductive Genetics, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Dhyani VS; Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Adiga P; Department of Reproductive Medicine and Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Mukherjee S; Department of Molecular Endocrinology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, Maharashtra, India., Adiga SK; Centre of Excellence in Clinical Embryology, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Uppangala S; Division of Reproductive Genetics, Department of Reproductive Science, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. shubha.u@manipal.edu. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Jun 05; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 05. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Estrogen Receptor alpha*/genetics , Estrogen Receptor beta*/genetics , Ovulation Induction*/methods , Polymorphism, Single Nucleotide* , Ovary* , Reproductive Techniques, Assisted*, Humans ; Female ; Alleles |
| Περίληψη: | Genetic factors contribute to poor ovarian response (POR) in assisted reproductive technology cycles, with estrogen receptor gene polymorphisms (ESR1 and ESR2) being explored as a causative factor in many studies. However, there is no systematic review and meta-analysis conducted on these studies to assess the association of these receptor polymorphisms on POR. This systematic review and meta-analysis evaluated the association between ESR1 and ESR2 single nucleotide polymorphisms (SNPs) and ovarian response in women undergoing controlled ovarian stimulation (COS). The study was registered with PROSPERO and conducted according to PRISMA guidelines. 11 eligible studies were included. Among the various SNPs, meta-analysis focused on ESR1 rs2234693 and rs9340799, and ESR2 rs4986938. ESR1 rs2234693 C‑allele carriers showed significantly increased odds of POR in both heterozygote (pooled log odds ratio (LOR) = 0.99, standard error (SE) = 0.213; odds ratio (OR) = 2.69, p < 0.001)) and dominant models (LOR = 1.69, SE = 0.449, OR = 5.41, p < 0.001), with consistent findings in European populations. Associations for ESR1 rs9340799 and ESR2 rs4986938 with POR showed substantial heterogeneity. Overall, ESR1 rs2234693 may be associated with POR, in women undergoing COS. Further large-scale studies with appropriate study designs are warranted to clarify the potential role of ESR polymorphisms in COS outcomes. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: The review study was exempt from institutional review board approval, as the study did not include any intervention. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: ART; Controlled ovarian stimulation; Estrogen receptor; Ovarian response; Single nucleotide polymorphisms |
| Substance Nomenclature: | 0 (Estrogen Receptor alpha) 0 (Estrogen Receptor beta) 0 (ESR1 protein, human) 0 (ESR2 protein, human) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260817 Latest Revision: 20260826 |
| Update Code: | 20260827 |
| PubMed Central ID: | PMC13482574 |
| DOI: | 10.1038/s41598-026-53350-5 |
| PMID: | 42248903 |
| Βάση Δεδομένων: | MEDLINE |
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