Academic Journal
Inhibiting methanogenesis with medium-chain fatty acids: strategy for rapid start-up and stable operation of food waste chain elongation systems.
| Τίτλος: | Inhibiting methanogenesis with medium-chain fatty acids: strategy for rapid start-up and stable operation of food waste chain elongation systems. |
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| Συγγραφείς: | Guo Y; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: 2311130011@nbu.edu.cn., Jia X; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: jiaxiwen@nbu.edu.cn., Chen Y; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: foreversosi722@outlook.com., Xu S; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: 2311130116@nbu.edu.cn., Ming T; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: mingtinghong@nbu.edu.cn., Kong F; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: kongfei@nbu.edu.cn., Xu J; School of Marine Science, Ningbo University, Ningbo, Zhejiang, China; Microbial Development and Metabolic Engineering Laboratory, Ningbo University, Ningbo, Zhejiang, China. Electronic address: xujiajie@nbu.edu.cn. |
| Πηγή: | Bioresource technology [Bioresour Technol] 2026 Oct; Vol. 458, pp. 135078. Date of Electronic Publication: 2026 Jun 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Barking, Essex, England : New York, N.Y. : Elsevier Applied Science ; Elsevier Science Pub. Co., 1991- |
| Ιατρικοί όροι (MeSH): | Methane*/biosynthesis , Fatty Acids*/metabolism , Fatty Acids*/chemistry, Bioreactors/microbiology ; Food Loss and Waste ; Fermentation ; Anaerobiosis ; Fatty Acids, Volatile |
| Περίληψη: | Converting food waste (FW) into medium-chain fatty acids (MCFAs) via chain elongation (CE) is an economical and eco-friendly approach, but methanogenic competition remains a key challenge limiting CE efficiency. Traditional inhibition methods (e.g., pH regulation, hydraulic/solids retention time control, chemical additives) require strict operation or external inputs, causing non-specific microbial inhibition, high costs and environmental risks. Innovatively, MCFAs can inherently suppress methanogens with obvious advantages. However, their inhibition mechanisms and dependence on concentration and carbon chain length remain unclear. This study investigated the effects of butyric acid (C4), caproic acid (C6), and caprylic acid (C8) at different concentrations on methane production, medium- and short-chain fatty acids accumulation, and microbial dynamics in FW anaerobic fermentation. The results indicated that the inhibitory effect was primarily driven by undissociated fatty acids, with the potency increasing with longer carbon chain lengths. Notably, C8 at a low undissociated concentration (0.05 mM) completely inhibited methanogenesis. Higher concentrations of C4, C6, and C8 effectively sustained hydrolysis and acidogenesis while promoting CE and leading to the accumulation of caproic acid and caprylic acid. Metagenomic analysis showed that a decline in methanogenesis-related functional genes was accompanied by an increase in reverse β-oxidation related functional genes. These findings provide a feasible strategy for rapid start-up and stable operation of FW-based CE systems, and present a sustainable route for FW valorization toward high-value biochemicals. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anaerobic fermentation; High-value conversion; Inhibitory effect; Microbial communities; Organic resources |
| Substance Nomenclature: | OP0UW79H66 (Methane) 0 (Food Loss and Waste) 0 (Fatty Acids) 0 (Fatty Acids, Volatile) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260721 Latest Revision: 20260721 |
| Update Code: | 20260721 |
| DOI: | 10.1016/j.biortech.2026.135078 |
| PMID: | 42248258 |
| Βάση Δεδομένων: | MEDLINE |
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