Academic Journal
Optimising composting to reduce plasmid and integrative conjugative element conjugation to minimise antibiotic resistomes in livestock manure for safe organic fertilisation.
| Τίτλος: | Optimising composting to reduce plasmid and integrative conjugative element conjugation to minimise antibiotic resistomes in livestock manure for safe organic fertilisation. |
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| Συγγραφείς: | Xu Z; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China., Zhang L; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China., Zhu D; Key Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China., Zhi S; Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China., Ashbolt NJ; SAAFECRC, School of Civil and Environmental Engineering, Queensland University of Technology, Brisbane, Qld 4000, Australia., Li G; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China., Luo W; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing 100193, China. Electronic address: luowenhai@cau.edu.cn., Nghiem LD; Centre for Technology in Water and Wastewater, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address: DucLong.Nghiem@uts.edu.au. |
| Πηγή: | Journal of hazardous materials [J Hazard Mater] 2026 Aug 01; Vol. 514, pp. 142573. Date of Electronic Publication: 2026 Jun 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| Ιατρικοί όροι (MeSH): | Manure*/microbiology , Composting*/methods , Plasmids*/genetics , Drug Resistance, Microbial*/genetics , Drug Resistance, Bacterial*/genetics , Fertilizers*, Anti-Bacterial Agents/pharmacology ; Animals ; Conjugation, Genetic ; Livestock ; Genes, Bacterial ; Temperature ; Swine |
| Περίληψη: | Antimicrobial resistance is a critical threat to organic fertilizer production from livestock manure by composting. This study provides new insights to the dynamics of antimicrobial resistance genes (ARGs) during composting to propose strategies for their elimination. Results from genome-resolved metagenomics, meta-analysis, and quantitative assessment showed temperature and moisture content as key factors governing ARG dynamics during composting. Although integrative conjugative elements (ICE) could be transferable by some thermophilic bacteria, composting temperature to above 60 °C reduces mobile ARGs driven by plasmid conjugation for elimination. Further controlling moisture content to low than 60% inhibits the secretion of extracellular polymeric substances to restrain ARG rebound by ICE conjugation, particularly at the maturation stage of composting. These results are significantly useful for China, where swine manure accounted for most of livestock manure-derived ARGs (91.5%). Applying findings from this study to optimise the composting of livestock manure could reduce ARG proliferation by up to 59.3% in China. (Crown Copyright © 2026. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antibiotic resistance genes (ARGs); Composting; Horizontal gene transfer (HGT); Livestock manure; Organic fertilization; Sustainable agriculture |
| Substance Nomenclature: | 0 (Manure) 0 (Fertilizers) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260725 Latest Revision: 20260725 |
| Update Code: | 20260725 |
| DOI: | 10.1016/j.jhazmat.2026.142573 |
| PMID: | 42248101 |
| Βάση Δεδομένων: | MEDLINE |
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