Academic Journal
Finerenone in Persons with Chronic Kidney Disease without Diabetes.
| Title: | Finerenone in Persons with Chronic Kidney Disease without Diabetes. |
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| Authors: | Heerspink HJL; George Institute for Global Health, University of New South Wales, Sydney.; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Neuen BL; George Institute for Global Health, University of New South Wales, Sydney.; Department of Renal Medicine, Royal North Shore Hospital, Sydney., Agarwal R; Division of Nephrology, Richard L. Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis., Cherney DZI; Division of Nephrology, University Health Network, Toronto General Hospital, University of Toronto, Toronto., Lam CSP; National Heart Centre Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore., Tuttle KR; Providence Inland Northwest Health, University of Washington School of Medicine, Spokane., Wanner C; Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany., Sarafidis P; First Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece., Jongs N; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Smeijer JD; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Brinker M; Cardiology and Nephrology Clinical Development, Bayer, Wuppertal, Germany., Rethemeier N; Clinical Statistics and Analytics, Bayer, Wuppertal, Germany., Schloemer P; Clinical Statistics and Analytics, Bayer, Berlin., Vesterinen P; Medical and Scientific Affairs, Bayer, Espoo, Finland., Goldsbury D; Bayer, Reading, United Kingdom., Dizayee S; Regulatory Strategy Cardiology and Nephrology, Bayer, Wuppertal, Germany., Mares JW; Bayer US Medical Affairs, Whippany, NJ., Perkovic V; University of New South Wales, Sydney. |
| Corporate Authors: | FIND-CKD Investigators |
| Source: | The New England journal of medicine [N Engl J Med] 2026 Aug 06; Vol. 395 (6), pp. 533-545. Date of Electronic Publication: 2026 Jun 04. |
| Publication Type: | Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Boston, Massachusetts Medical Society. |
| MeSH Terms: | Albuminuria*/diagnosis , Albuminuria*/drug therapy , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/prevention & control , Naphthyridines*/adverse effects , Naphthyridines*/therapeutic use , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/diagnosis , Renal Insufficiency, Chronic*/drug therapy , Heart Failure*/epidemiology , Heart Failure*/etiology , Heart Failure*/prevention & control , Heart Failure*/therapy, Glomerular Filtration Rate/drug effects ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Mineralocorticoid Receptor Antagonists/adverse effects ; Hyperkalemia/chemically induced ; Hyperkalemia/epidemiology ; Hospitalization/statistics & numerical data ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/prevention & control ; Aged ; Female ; Humans ; Male ; Middle Aged ; Double-Blind Method ; Adult ; Treatment Outcome |
| Abstract: | Background: In randomized trials, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease (CKD). Whether finerenone has similar effects in patients without diabetes who have CKD is unknown. Methods: We randomly assigned adults without diabetes who had CKD (estimated glomerular filtration rate [eGFR], 25 to <90 ml per minute per 1.73 m2 of body-surface area) and albuminuria (urinary albumin-to-creatinine ratio, 200 to ≤3500, with albumin in milligrams and creatinine in grams) and were using a renin-angiotensin system inhibitor to receive finerenone (10 or 20 mg daily) or placebo. The primary outcome was the total eGFR slope (mean annual rate of change in the eGFR from baseline to month 32), assessed with a two-slope linear spline mixed-effects model. Secondary outcomes included a composite of kidney or cardiovascular events (reduction from baseline of at least 57% in the eGFR, kidney failure, hospitalization for heart failure, or death from cardiovascular causes), a composite of the two kidney events, and a composite of the two cardiovascular events. Results: A total of 1584 participants underwent randomization - 793 were assigned to the finerenone group, and 791 to the placebo group. The mean (±SD) baseline eGFR was 46.8±16.2 ml per minute per 1.73 m2 with finerenone and 46.6±16.0 ml per minute per 1.73 m2 with placebo. The mean annual rate of change in the eGFR from baseline to month 32 was -3.3 ml per minute per 1.73 m2 (95% confidence interval [CI], -3.6 to -3.1) with finerenone and -4.0 ml per minute per 1.73 m2 (95% CI, -4.3 to -3.8) with placebo (difference, 0.7; 95% CI, 0.3 to 1.1; P<0.001). Prespecified hierarchical testing showed that the risk of a composite kidney or cardiovascular outcome event was lower with finerenone than with placebo (hazard ratio, 0.77; 95% CI, 0.60 to 0.99; P = 0.04); the hazard ratio was 0.78 (95% CI, 0.60 to 1.01) for the composite of the two kidney events and 0.60 (95% CI, 0.27 to 1.33) for the composite of the two cardiovascular events. The most common adverse event was hyperkalemia (135 participants [17.0%] with finerenone and 105 [13.3%] with placebo); hyperkalemia events led to discontinuation of the trial regimen in 12 participants (1.5%) and 1 participant (0.1%), respectively, and to hospitalization in 7 (0.9%) and 5 (0.6%). Conclusions: Among adults with CKD who did not have diabetes, finerenone led to a slower decrease in the eGFR than placebo over 32 months. (Funded by Bayer; FIND-CKD ClinicalTrials.gov number, NCT05047263.). (Copyright © 2026 Massachusetts Medical Society.) |
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CY Chou; PF Chiu; YL Chiu; YP Hsieh; HH Hsu; TM Huang; CC Hung; CC Jiang; JY Jiang; SW Ju; CC Kao; HL Kuo; CF Lai; TS Lai; CC Lee; WC Lee; LC Li; SY Lin; SL Lin; YC Lin; YS Peng; KH Shu; CC Tsai; SF Tsai; IK Wang; JS Wang; CL Wu; CY Wu; MJ Wu; VC Wu; CW Yang; HY Yang; JY Yang; SY Yang; YF Yang; Y Yang; WS Yang; TM Yu; K McCafferty; K Bramham; J Chong; T Cornish; T Doulton; C Farmer; S Griffin; C Hall; A Khwaja; M Leung; J Moriarty; T Pickett; S Saminathan; S Shah; N Shah; A Al Shami; A Shardlow; P Smith; M Wilkie; A Wonnacott; P Pergola; U Abdumomiov; I Agha; O Albajrami; M Aldahan; I Algantrani; R Alicic; S Alla; C Almanza; T Al-Tuhaifi; S Anand; AC Anatalio; F Arman; M Atta; A Awad; SN Babar; S Bansal; L Bantugan; A Barz; A Basford; JL Bates; S Beddhu; R Berenji; N Bhasin; M Bien; T Bjordahl; K Blackwood; E Bortequate; J Bruneau; N Bryant; W Bryant; AK Buckle; GN Buerkle; A Burgner; J Burgos; J Camacho; K Campbell; D Castrilla; I Castro-Revoredo; U Challa; A Chang; E Chang; L Cherem; WY Chiang; J Chittum; M Chonchol; M Chowdhury; C Christiano; C Chu; J Clark; S Clarke; S Collins; T Conger; J Connaire; RW Coomer; H Coore; P Crawford; Y DaCosta-Auld; N Dahl; M Das; A Davis; Y Deleon; M Diamond; J Manilo Dieck; B Dixon; M Dobre; N Dossabhoy; D Drew; C Duran-Martinez; S Elahi; V Espinoza; E Fels; P Fish; F Fleszler; N Freking; A Frome; C Gallego; P Garavaglia; B Garcia; I Garcia; R Goshtaseb; E Gould; ME Grant; R Gromala; A Gupta; M Hall; S Howard Ham; S Hamby; IJ Hanna; S Hanzl; AK Harlacher; M Hassanein; J Havill; K Hendon; J Herion; G Hernandez; D Highsmith; A Horeish; N Hristea; IL Hudson; T Hunkapiller; S Hussain; R Abu Hweij; T Idrees; R Indahyung; L Inker; S Iskapallim; J Jaffe; DI Jalal; A Jamal; D Jean-Louis; CS Jenkins; A Jovanovich; K Kalra; M Kamgar; S Kansal; MO Kaskas; J Kendrick; A Kennedy; S Khaleel; NA Khan; E Kirk; N Kopyt; W Kotzker; L Kupor; MP Law; I Leal; B Lee; RM Lustig; K Lyman; C Mack; G Maharjan; S Trevino Manilo; R Manllo-Karim; L Mayerson; N McCall; E McCarthy; C McClurkin; A Mehdi; R Mendez; J Meouchy; J Meyer; D Michaud; A Mirkhel; M Moghadam; D Mondero; R Moore; G Morell; A Mottl; J Moussa; RK Moussa; M Moustafa; MJ Mudry; R Nadella; O Naik; S Naila; G Nakhoul; T Nassar; L Negrea; G Newman; J Nguyen; N Nobakht; Y Obi; N Ogletree; M Olsen; K Ortiz; JG Owen; A Pacheco; A Padiyar; S Panse; B Paredes; J Partola; B Paueksakon; M Peevy; NN Perez; E Pierson; N Pradhan; R Pratley; L Preysner; P Pronovost; C Pysher; M Quadrini; R Quillman; D Rabideau; M Rahman; S Raissi; R Ralph; A Rashidi; A Rastogi; K Reaves; M Reed; M Reed; L Reid; K Reiner; S Reynolds; D Rhodes; H Richmond; SAA Rizvi; A Rizvi; A Rizvi; D Robinson; J Roesch; AM Romo; BP Ross; D Ross; M Salani; M Sandid; N Sarabu; M Sarkar; D Schmidt; A Schutt; T Shafi; L Short; K Shumburo; M Sika; K Simpson; MKM Siu; M Slayton; C Smith; M Smith; M Smith; K Solanki; J Soufer; D Speer; J Sperati; T Spinola; E Swoopes; J Taliercio; R Tanner; R Tasin; S Thaxton; T Thethi; G Thomas; S Tillman; MCYO Tio; J Tolins; J Turner; K Tuttle; SM Udani; K Umanath; G Umpierrez; A Valliant; J Vasallo; R Vigo-Vigo; A Wagner; M Walsh; G Wang; D Weiner; C Wells; K Matulonis Williams; B Williamson; K Wilt; C Wong; J Woodward; P Worthington; Z Yablon; O Yee; A Yue; RI Zabaneh; S Zaidi; JS Zbinden; HJL Heerspink; BL Neuen; R Agarwal; DZI Cherney; CSP Lam; KR Tuttle; C Warner; V Perkovic; GM Chertow; M Epstein; T Friede; A Levin; JFE Mann; JD Smeijer; N Jongs; M Brinker; N Li; N Rethemeier; D Burger; J Pawlitschko; K Mueller; J Reis; S Janitza; J Lay-Flurrie; P Schloemer; Y De Sanctis; C Ahlers; S Kuhls; M Figueras Balsells; C Scott; A Tuemer; C Klein; C Ellenberger; A Appana; M Shukla; S Thogari; M Bainaboyina; R Annapureddy; N Einfuehrer; R Neela; P Vesterinen; MY Finkelsztein; M Chen; J Augusto; C Serrano Redonnet; C Yamaguti; F Czekalla; J Sundaram; A Horvat-Broecker; D Goldsbury; J Disney; N Beakhouse; M Kusiak; N Richardson; D Alta; T Sadeoja; J Chen; L West; S Collamati; M Gregory; M Lombard; X Zhao; J Buytendach |
| Molecular Sequence: | ClinicalTrials.gov NCT05047263 |
| Substance Nomenclature: | DE2O63YV8R (finerenone) 0 (Mineralocorticoid Receptor Antagonists) 0 (Naphthyridines) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260805 Latest Revision: 20260910 |
| Update Code: | 20260910 |
| DOI: | 10.1056/NEJMoa2604625 |
| PMID: | 42246672 |
| Database: | MEDLINE |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: cmedm DbLabel: MEDLINE An: 42246672 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Finerenone in Persons with Chronic Kidney Disease without Diabetes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Heerspink+HJL%22">Heerspink HJL</searchLink>; George Institute for Global Health, University of New South Wales, Sydney.; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Neuen+BL%22">Neuen BL</searchLink>; George Institute for Global Health, University of New South Wales, Sydney.; Department of Renal Medicine, Royal North Shore Hospital, Sydney.<br /><searchLink fieldCode="AU" term="%22Agarwal+R%22">Agarwal R</searchLink>; Division of Nephrology, Richard L. Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Cherney+DZI%22">Cherney DZI</searchLink>; Division of Nephrology, University Health Network, Toronto General Hospital, University of Toronto, Toronto.<br /><searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; National Heart Centre Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tuttle+KR%22">Tuttle KR</searchLink>; Providence Inland Northwest Health, University of Washington School of Medicine, Spokane.<br /><searchLink fieldCode="AU" term="%22Wanner+C%22">Wanner C</searchLink>; Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sarafidis+P%22">Sarafidis P</searchLink>; First Department of Nephrology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Jongs+N%22">Jongs N</searchLink>; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Smeijer+JD%22">Smeijer JD</searchLink>; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Brinker+M%22">Brinker M</searchLink>; Cardiology and Nephrology Clinical Development, Bayer, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Rethemeier+N%22">Rethemeier N</searchLink>; Clinical Statistics and Analytics, Bayer, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Schloemer+P%22">Schloemer P</searchLink>; Clinical Statistics and Analytics, Bayer, Berlin.<br /><searchLink fieldCode="AU" term="%22Vesterinen+P%22">Vesterinen P</searchLink>; Medical and Scientific Affairs, Bayer, Espoo, Finland.<br /><searchLink fieldCode="AU" term="%22Goldsbury+D%22">Goldsbury D</searchLink>; Bayer, Reading, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dizayee+S%22">Dizayee S</searchLink>; Regulatory Strategy Cardiology and Nephrology, Bayer, Wuppertal, Germany.<br /><searchLink fieldCode="AU" term="%22Mares+JW%22">Mares JW</searchLink>; Bayer US Medical Affairs, Whippany, NJ.<br /><searchLink fieldCode="AU" term="%22Perkovic+V%22">Perkovic V</searchLink>; University of New South Wales, Sydney. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22FIND-CKD+Investigators%22">FIND-CKD Investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220255562%22">The New England journal of medicine</searchLink> [N Engl J Med] 2026 Aug 06; Vol. 395 (6), pp. 533-545. <i>Date of Electronic Publication: </i>2026 Jun 04. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Massachusetts+Medical+Society%22">Massachusetts Medical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0255562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1533-4406 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200284793%22">00284793 </searchLink><i>NLM ISO Abbreviation: </i>N Engl J Med <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: Boston, Massachusetts Medical Society. – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Albuminuria%22">Albuminuria*</searchLink>/<searchLink fieldCode="MM" term="%22Albuminuria+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Albuminuria%22">Albuminuria*</searchLink>/<searchLink fieldCode="MM" term="%22Albuminuria+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Cardiovascular+Diseases%22">Cardiovascular Diseases*</searchLink>/<searchLink fieldCode="MM" term="%22Cardiovascular+Diseases+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cardiovascular+Diseases%22">Cardiovascular Diseases*</searchLink>/<searchLink fieldCode="MM" term="%22Cardiovascular+Diseases+mortality%22">mortality</searchLink> <br /><searchLink fieldCode="MM" term="%22Cardiovascular+Diseases%22">Cardiovascular Diseases*</searchLink>/<searchLink fieldCode="MM" term="%22Cardiovascular+Diseases+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Naphthyridines%22">Naphthyridines*</searchLink>/<searchLink fieldCode="MM" term="%22Naphthyridines+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Naphthyridines%22">Naphthyridines*</searchLink>/<searchLink fieldCode="MM" term="%22Naphthyridines+therapeutic+use%22">therapeutic use</searchLink> <br /><searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic%22">Renal Insufficiency, Chronic*</searchLink>/<searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic+complications%22">complications</searchLink> <br /><searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic%22">Renal Insufficiency, Chronic*</searchLink>/<searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic%22">Renal Insufficiency, Chronic*</searchLink>/<searchLink fieldCode="MM" term="%22Renal+Insufficiency%2C+Chronic+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+epidemiology%22">epidemiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Heart+Failure%22">Heart Failure*</searchLink>/<searchLink fieldCode="MM" term="%22Heart+Failure+therapy%22">therapy</searchLink><br /><searchLink fieldCode="MH" term="%22Glomerular+Filtration+Rate%22">Glomerular Filtration Rate</searchLink>/<searchLink fieldCode="MH" term="%22Glomerular+Filtration+Rate+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Mineralocorticoid+Receptor+Antagonists%22">Mineralocorticoid Receptor Antagonists</searchLink>/<searchLink fieldCode="MH" term="%22Mineralocorticoid+Receptor+Antagonists+therapeutic+use%22">therapeutic use</searchLink> ; <searchLink fieldCode="MH" term="%22Mineralocorticoid+Receptor+Antagonists%22">Mineralocorticoid Receptor Antagonists</searchLink>/<searchLink fieldCode="MH" term="%22Mineralocorticoid+Receptor+Antagonists+adverse+effects%22">adverse effects</searchLink> ; <searchLink fieldCode="MH" term="%22Hyperkalemia%22">Hyperkalemia</searchLink>/<searchLink fieldCode="MH" term="%22Hyperkalemia+chemically+induced%22">chemically induced</searchLink> ; <searchLink fieldCode="MH" term="%22Hyperkalemia%22">Hyperkalemia</searchLink>/<searchLink fieldCode="MH" term="%22Hyperkalemia+epidemiology%22">epidemiology</searchLink> ; <searchLink fieldCode="MH" term="%22Hospitalization%22">Hospitalization</searchLink>/<searchLink fieldCode="MH" term="%22Hospitalization+statistics+%26+numerical+data%22">statistics & numerical data</searchLink> ; <searchLink fieldCode="MH" term="%22Kidney+Failure%2C+Chronic%22">Kidney Failure, Chronic</searchLink>/<searchLink fieldCode="MH" term="%22Kidney+Failure%2C+Chronic+epidemiology%22">epidemiology</searchLink> ; <searchLink fieldCode="MH" term="%22Kidney+Failure%2C+Chronic%22">Kidney Failure, Chronic</searchLink>/<searchLink fieldCode="MH" term="%22Kidney+Failure%2C+Chronic+prevention+%26+control%22">prevention & control</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Double-Blind+Method%22">Double-Blind Method</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: In randomized trials, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease (CKD). Whether finerenone has similar effects in patients without diabetes who have CKD is unknown.<br />Methods: We randomly assigned adults without diabetes who had CKD (estimated glomerular filtration rate [eGFR], 25 to &lt;90 ml per minute per 1.73 m<superscript>2</superscript> of body-surface area) and albuminuria (urinary albumin-to-creatinine ratio, 200 to ≤3500, with albumin in milligrams and creatinine in grams) and were using a renin-angiotensin system inhibitor to receive finerenone (10 or 20 mg daily) or placebo. The primary outcome was the total eGFR slope (mean annual rate of change in the eGFR from baseline to month 32), assessed with a two-slope linear spline mixed-effects model. Secondary outcomes included a composite of kidney or cardiovascular events (reduction from baseline of at least 57% in the eGFR, kidney failure, hospitalization for heart failure, or death from cardiovascular causes), a composite of the two kidney events, and a composite of the two cardiovascular events.<br />Results: A total of 1584 participants underwent randomization - 793 were assigned to the finerenone group, and 791 to the placebo group. The mean (±SD) baseline eGFR was 46.8±16.2 ml per minute per 1.73 m<superscript>2</superscript> with finerenone and 46.6±16.0 ml per minute per 1.73 m<superscript>2</superscript> with placebo. The mean annual rate of change in the eGFR from baseline to month 32 was -3.3 ml per minute per 1.73 m<superscript>2</superscript> (95% confidence interval [CI], -3.6 to -3.1) with finerenone and -4.0 ml per minute per 1.73 m<superscript>2</superscript> (95% CI, -4.3 to -3.8) with placebo (difference, 0.7; 95% CI, 0.3 to 1.1; P&lt;0.001). Prespecified hierarchical testing showed that the risk of a composite kidney or cardiovascular outcome event was lower with finerenone than with placebo (hazard ratio, 0.77; 95% CI, 0.60 to 0.99; P = 0.04); the hazard ratio was 0.78 (95% CI, 0.60 to 1.01) for the composite of the two kidney events and 0.60 (95% CI, 0.27 to 1.33) for the composite of the two cardiovascular events. The most common adverse event was hyperkalemia (135 participants [17.0%] with finerenone and 105 [13.3%] with placebo); hyperkalemia events led to discontinuation of the trial regimen in 12 participants (1.5%) and 1 participant (0.1%), respectively, and to hospitalization in 7 (0.9%) and 5 (0.6%).<br />Conclusions: Among adults with CKD who did not have diabetes, finerenone led to a slower decrease in the eGFR than placebo over 32 months. (Funded by Bayer; FIND-CKD ClinicalTrials.gov number, NCT05047263.).<br /> (Copyright © 2026 Massachusetts Medical Society.) – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Investigator: </i>R Maldonado; P Aguerre; P Arenas; M Arriola; CE Baccaro; M Bevilacqua; J Bittar; D Brodschi; J Caceres; G Campestri; MC Cantero; S Cardona; F Casan; E Cassini; G Catalano; M Chahin; N Cluigt; AF Comes; P Delgado; MP Dionisi; S Dominguez; R Fernandez; E Gelersztein; S Giacometti; DA Mohr Gosparini; FP Guerlloy; F Halac; MA Hominal; C Igarzabal; V Lacoste; M Leis; P Martinez; V Rama; L Rodriguez; S Rodriguez; L Rovegno; B Saenz; MV Sobredo; M Suarez; P Varela; G Villalobo; S Virginia; D Waserman; DM Zaccaro; J Zaidman; D Packham; S Badve; M Cheetham; J Chen; K Ducharlet; D Degen; Y Eqbal; A Flavell; C Foote; N Gray; C Hawley; P Hollett; J Holt; L Huang; N Isbel; D Jegatheesan; R Krishnasamy; C Lai; C Lane; D Lee; K Mahadevan; G Mangos; E Noble; E Pedagogos; M Razavian; A Ritchie; M Roberts; K Robson; S Sen; A Wang; J Waugh; MG Wong; L Wynter; M Speeckaert; B Bammens; K Claes; M Decupere; K De Vusser; B Dubois; P Doubel; P Evenepoel; M Jadoul; F Jouret; L Labriola; B Maes; T Malfait; G Meeus; B Meijers; M Naesens; O Schockaert; WV Biesen; A Van Craenenbroeck; E Van Regemorter; A Vanacker; L Viaene; S Stamova; G Arabadzhiev; L Atanasov; S Bilcheva; C Dimitrov; I Dimitrova; I Georgiev; I Gerchev; L Hristov; V Hristozov; S Ilchev; G Ivanov; Y Ivanova; B Ivanova-Terzieva; K Kichukov; N Koleva; G Lichev; G Marinova-Racheva; G Mazhdrakov; I Mehmedov; L Nikolova; I Rumen; P Pelov; R Petrova; B Stoimenov; G Stoyanova; V Stoyanova; V Todorova; V Tsenov; A Vasileva; D Vasileva; L Vasileva-Boyadzhieva; T Vutova; T Yuztyurk; V Zhelev; X Chen; Y Adelibieke; J Bai; W Bian; K Cai; Y Cai; J Cao; L Chai; S Chahan; X Chang; H Cheng; J Cheng; B Chen; C Chen; C Chen; J Chen; L Chen; L Chen; M Chen; Q Chen; Q Chen; R Chen; W Chen; X Chen; X Chen; Y Chen; C Cui; S Cui; Y Cui; X Ding; X Ding; J Dong; L Dong; X Dong; J Du; X Du; W Fan; M Fang; X Feng; Y Geng; W Gong; Y Gu; Y Guan; L Guo; L Guo; Q Guo; T Guo; Z Guo; S Guzailinuer; D Hao; Y Hao; Q He; W He; X He; Y He; X Hou; H Hu; J Hu; P Hu; W Hu; Y Hu; C Huang; Q Huang; S Huang; W Huang; G Jiang; C Jia; Y JIan; L Jin; B Li; H Li; J Li; J Li; J Li; L Li; L Li; M Li; P Li; P Li; Q Li; S Li; W Li; W Li; Y Li; Y Li; Y Li; Z Li; H Liang; W Liang; Y Liang; H Lin; K Lin; Y Lin; B Liu; C Liu; C Liu; D Liu; F Liu; F Liu; F Liu; G Liu; H Liu; H Liu; L Liu; L Liu; Q Liu; S Liu; S Liu; Y Liu; Z Liu; G Long; H Long; Y Long; B Lu; W Lu; X Lu; C Luo; P Luo; Q Luo; X Lv; Y Lv; X Ma; X Meng; L Ni; L Ning; D Niu; J Niu; X Pan; Y Pan; F Peng; C Qin; H Qin; W Qiu; W Ren; Z Ren; Z Rexidan; W Shang; S Shao; S Shi; X Shi; Y Shi; Y Shi; B Su; B Su; K Su; W Sun; X Sun; Y Sun; S Tang; X Tang; Y Tang; Y Tang; Y Tang; Q Tao; M Tian; H Tu; Y Tu; J Wan; B Wang; C Wang; D Wang; D Wang; F Wang; F Wang; F Wang; H Wang; J Wang; J Wang; K Wang; L Wang; L Wang; R Wang; R Wang; S Wang; X Wang; X Wang; Y Wang; Y Wang; Y Wang; Z Wang; Z Wang; H Wei; X Wei; Z Wei; Z Wei; C Wu; G Wu; G Wu; M Wu; Q Wu; S Wu; X Wu; Y Wu; Y Xia; Q Xian; X Xiao; F Xiong; L Xiang; B Xu; F Xu; H Xu; J Xu; J Xu; L Xu; Q Xu; X Xu; Y Xu; X Xie; B Yan; J Yan; R Yan; A Yang; D Yang; J Yang; M Yang; X Yang; Y Yang; Y Yang; Q Yao; N Ye; X You; C Yu; J Yu; M Yu; T Yu; X Yu; Y Yu; Y Yu; J Yuan; L Zeng; R Zeng; C Zhang; E Zhang; H Zhang; H Zhang; J Zhang; J Zhang; J Zhang; J Zhang; J Zhang; L Zhang; M Zhang; M Zhang; X Zhang; X Zhang; Y Zhang; J Zhao; Y Zhao; Z Zhao; L Zheng; M Zheng; Q Zheng; Y Zheng; Y Zhong; F Zhou; H Zhou; W Zhou; X Zhou; Y Zhou; H Zhu; Y Zhuge; L Zhuo; C Zou; G Zou; J Zou; Y Zou; Y Zou; M Prazny; P Bucek; K Chadimova; P Divacka; L Fantova; M Goluchova; L Hornova; M Lukac; M Majernikova; J Matuska; H Mrlianova; J Pecirkova; J Rehorova; J Senitko; J Skrha; S Svobodova; S Vankova; M Weiss; J Wirth; M Hornum; J Bech; I Bressendorf; P Clausen; SL Høyer Finsen; S Chaudhary Hauge; D Hansen; GR Hinrichs; CB Juhl; D Kofod; M Lindhardt; EE Mannheimer; FH Mose; LA Mortensen; K Brochner Ostergaard; IM Hjelm Soerensen; MA Tolstrup; E Papachristou; A Alexandros; ME Alexandrou; D Apostolakis; K Armetzioiou; G Bamichas; C Bantis; M Bakou; I Boletis; M Bora; A Bratsiakou; A Chalkia; KE Dermitzaki; C Dimitriadis; E Drosataki; A Duni; M Erotokritou; S Fragkidis; M Garoufis; P Giamalis; D Goumenos; C Gouva; A Kapota; A Karras; GA Kavvadias; T Kouloukourgiotou; P Kyriklidou; A Loli; A Lysitska; I Mallioras; E Manou; S Marinaki; E Mitsopoulos; A Mountzourogeorgou; A Ntemka; E Ntounousi; D Papadopoulou; A Papagianni; M Papapanagiotou; M Papasotiriou; S Paschou; P Pateinakis; I Petrakis; D Petras; P Sarafidis; C Skalioti; M Smyrli; G Spanos; M Stangou; K Stylianou; MP Theodorakopoulou; I Theodorou; M Triantafyllidou; I Tsouchnikas; K Vallianou; E Xagas; SCW Tang; ATP Chan; GCW Chan; A Cheuk; SKS Fung; LPY Kwan; KM Lee; W Lee; V Li; DNW Lie; SL Lui; JKC Ng; CC Szeto; AHC Tang; HL Tang; JTW Wu; JMK Yeung; L Kovacs; G Bencze; H Boulellou; D Csaplaros; S Csitneki; P Endredy; R Kirschner; T Kovacs; A Nemeth; T Szelestei; T Szalay; I Wittmann; P Zilahi; Z Zilahi; S Agarwal; S Nicholas; N Aghor; A Almeida; V Arumugam; S Arunkumar; GD Chhabra; A Dey; K Gandhi; N Gopalakrishnan; N Gracious; A Ignatius; S Khiste; D Khullar; A Kodre; VR Krishnakumar; TM Lamech; S Mavani; A Pal; R Pandey; S Ramanathan; M Sahay; R Sahay; P Sandesh; M Shah; R Shinde; R Sirsat; D Sl; B Soumita; J Swapnil; D Thanigachalam; A V; B Rozen-Zvi; N Abu-Amer; W Amon; A Badran; D Bar-Nur; A Basok; O Kliuk-Ben Bassat; I Beberashvili; P Beckerman; S Ben Chetrit; K Cohen-Hagai; N Ben Dor; R Biton; G Chernin; I El Sayed; E Farber; R Gantus; A Hanut; M Hausmann; Y Haviv; Y Horwich; G Jeiris; Z Katzir; R Kazarsky; Y Kenig; I Kenis; AA Korman; E Kruzel-Davila; OL Kukuy; L Lebedev; A Leiba; R Levi-Varadi; N Levin-Iaina; A Mikhlin; S Mini-Goldberger; V Morduhovich; N Nacasch; C Oren; H Qasim; I Rahmani Tzvi Ran; V Rapoport; M Raz; I Rubinchik; M Sapojnikov; T Scheib; D Schwartz; M Shalaata; P Sheinberg; M Tchircov; O Vdovich; M Vorobiov; A Wechsler; Y Yagil; T Zeitun; R Minutolo; V Aiello; TP Ambrosino; R Baccaro; G Battini; G Bigatti; FG Boni; S Bruno; I Capelli; G Cappelli; FMI Carminati; R Cimino; I Colombini; F Cosa; E Cristini; E Daina; M Delsante; G Donati; C Esposito; V Esposito; E Fiaccadori; A Ferrari; A Franculli; S Giberti; B Gidaro; II Giordano; G Grandaliano; MC Gregorini; CM Guastoni; F Guglielmi; A Parvanova Ilieva; G La Manna; S Lerario; ME Liberti; R Mancini; A Marino; C Minicucci; B Morda; N Morisi; E Olivo; C Paccagnella; MC Pacchiarini; A Palladini; RF Rivera; L Rimoldi; G Santorelli; R Savino; R Scarmignan; A Scrivo; G Sileno; E Tinti; M Trillini; A Vella; M Nangaku; E Abe; K Abe; K Abe; M Abe; T Abe; S Adachi; S Ako; H Amano; M Amemiya; D Aomura; K Ayana; K Azushima; K Baba; S Baba; A Ban; Y Beppu; K Chiba; R China; I Daisuke; M Ebihara; Y Eto; F Fujii; M Fujii; N Fujii; T Fujii; Y Fujii; M Fujimura; K Fujisaki; M Fujishiro; M Fujita; Y Fujita; M Fukagawa; K Fukami; Y Fukao; D Fukaya; Y Fuke; H Fukuda; N Fukuda; S Fukuda; Y Fukuda; K Fukuhara; Y Fukuhara; K Fukumitsu; A Fukuoka; R Furuta; F Furuya; T Gohda; K Goto; S Goto; R Haga; J Hagita; T Hamano; S Hamanoue; T Hamashoji; A Hara; K Harada; M Harada; K Hashimoto; T Hayakawa; M Hayashi; S Hemmi; Y Hidaka; F Hideki; N Hidenori; R Higashide; S Higuchi; T Hirai; A Hirano; S Hirata; H Hirose; T Hirose; H Hiyamuta; R Honda; K Horikoshi; S Horikoshi; T Hoshino; F Ihara; H Ikai; E Ikeda; M Ikeda; Y Ikeda; K Ikeshita; A Imono; K Imoto; M Inoue; N Inoue; T Inoue; K Inui; S Irie; K Ishiga; T Ishihara; M Ishii; T Ishii; M Ishizaka; T Ishizuka; R Isohata; A Itano; S Itano; D Ito; K Ito; S Ito; Y Ito; Y Ito; R Iwabuchi; T Iwakura; T Iwamoto; K Iwasaki; M Iwasaki; Y Iwata; M Kado; H Kadoya; E Kajimoto; M Kambayashi; Y Kamijo; A Kamio; D Kanai; G Kanai; H Kanai; T Kanaoka; T Kanbe; E Kanda; H Kaneoka; T Kanno; Y Kanno; C Kano; R Kasahara; R Kasai; N Kashihara; T Kasugai; A Kato; M Kato; K Kawada; Y Kawai; M Kawakami; K Kawasaki; T Kawata; O Kazuhiro; K Kidokoro; M Kihara; S Kimura; S Kimura; Y Kimura; S Kinguchi; S Kishi; Y Kishima; K Kitagawa; M Kitai; S Kitajima; S Kitamura; H Kobayashi; M Kobayashi; R Kobayashi; T Kobayashi; T Kobayashi; T Kobayashi; H Koda; T Kodama; K Kohatsu; S Koide; G Koizumi; M Koizumi; M Kokubu; W Kokuryo; H Komaba; S Komiya; M Kondo; T Kondo; M Konishi; K Kono; T Koshida; H Kotake; Y Kozaki; M Kurahashi; F Kuwahara; M Lee; Y Maeda; M Maiguma; M Maki; Y Makita; Y Makita; Y Marumi; T Maruyama; A Masaki; K Masutani; D Matsui; M Matsui; N Matsui; H Matsumoto; K Matsumoto; H Matsuoka; H Matsuoka; Y Matsuura; I Mimura; T Minami; T Minamisawa; T Misaki; S Misegawa; Y Miyabe; T Miyagawa; K Miyamoto; Y Miyaoka; H Miyasato; T Miyazaki; R Miyazawa; M Mizuno; M Mizuta; A Mori; D Mori; K Mori; R Morita; R Morita; T Moriyama; Y Murai; M Murashima; Y Murata; T Muta; M Muto; Y Muto; M Nagai; Y Nagano; A Nagasawa; F Nagase; K Nagase; A Nagashima; H Nagasu; K Nagatoya; M Nakagaki; S Nakagawa; S Nakagawa; Y Nakagawa; Y Nakamata; M Nakamura; Y Nakamura; Y Nakamura; Y Nakano; S Nakashita; J Nakata; I Nakaya; M Nakayama; Y Nakayama; A Nambu; Y Namiki; Y Naruse; H Nawata; M Nawata; Y Nihei; T Nimura; H Nishi; S Nishi; M Nishikawa; T Nobuoka; A Noda; K Noda; H Nomi; A Nomizu; A Nomura; N Nosho; A Nozaki; S Ochiai; A Oda; R Oda; T Ogasa; A Ogawa; H Oguma; H Ogura; Y Ohara; A Ohashi; K Ohki; K Ohori; H Okada; E Okamoto; H Okamoto; K Okamura; M Okamura; N Okamura; G Okanishi; J Okita; K Okoshi; A Okuno; M Ono; S Ono; K Osako; K Osano; J Oshikawa; M Oshima; T Oshita; J Ota; Y Otomo; T Otsuka; J Oyama; S Ozaki; M Ozawa; T Ozeki; K Reo; T Rikihisa; M Saeki; M Saito; R Saito; S Saito; T Saito; S Saka; N Sakai; K Sakamoto; T Sakurada; S Sasaki; T Sasaki; Y Sasaki; Y Sasatsuki; J Sato; K Sato; K Sato; Y Sato; Y Sato; Y Sawada; S Sawaki; Y Seki; Y Shibagaki; M Shibata; M Shimada; Y Shimada; S Shimamoto; N Shimamura; H Shimizu; M Shimizu; M Shimizu; M Shimizu; Y Shimizu; S Shirai; Y Shun; K Soeda; J Soma; W Sone; Y Sonezaki; M Sotozawa; H Suga; M Sugahara; A Sugimachi; M Sugita; Y Sumitani; H Suwa; Y Suwa; H Suzuki; S Suzuki; Y Suzuki; K Tada; Y Tadanawa; G Tagami; T Taguchi; M Takagi; H Takahara; K Takahashi; K Takahashi; J Takami; H Takashima; T Takatsuka; Y Takeda; M Takeuchi; R Takeuchi; M Takizawa; N Takizawa; S Tamai; Y Tamayama; K Tamura; M Tamura; Y Tamura; S Tanaka; S Tanaka; T Tanaka; Y Tanaka; Y Taniguchi; H Tanoue; K Tansho; R Tatsugawa; R Tatsumoto; R Tei; Y Tobari; M Toda; T Toda; M Tokuchi; S Tomita; T Tomonari; K Tomori; K Toshiki; T Toya; Y Toya; T Toyama; M Toyoda; K Toyota; K Tsubota; S Tsukamoto; H Tsushima; K Uchimura; E Ueda; S Ueda; S Ueda; R Umeno; Y Umezawa; S Urate; M Wada; T Wada; T Wada; Y Wada; H Wakui; N Waseda; M Watada; K Watanabe; S Watanabe; T Watanabe; Y Watanabe; Y Watanabe; H Yabuta; A Yamada; K Yamada; S Yamada; Y Yamada; K Yamaka; E Yamamoto; K Yamamoto; M Yamamoto; M Yamamoto; T Yamamoto; Y Yamamura; T Yamanaka; M Yamane; S Yamane; A Yamanishi; Y Yamanouchi; A Yamauchi; R Yasuhara; T Yasuno; M Yazawa; M Yoda; Y Yokoyama; S Yonemoto; H Yoshida; Y Yoshida; S Yoshimura; M Yoshino; Y Yoshitake; T Yuasa; J Yuto; WAH Wan Md Adnan; NNH Zainal Abidin; MK Ahmad; NH Ahmad; N Ali; WAS Rozli Wan Ali; K Appava; AA Aziz; AZ Bahtar; S Bavanandam; CE Chan; ML Chang; CC Chew; CL Chew; CL Chong; SQR Choo; W Choong; LH Chuan; SQ Ee; FH Muhamad Fawzi; ZL Go; S Govindan; SHM Ismail; MASA Kader; HY Kang; N Kamarudin; SR Krishnamurthy; K Krishnan; AK Lee; KQ Lee; LY Lee; SA Lee; YY Lee; KW Liew; XM Lim; CL Loh; YK Looi; JM Low; DY Mah; SAD Mazlan; WH Wan Mohamad; TJ Ng; FS Mohamad Nor; HA Keya Nordin; NZ Nordin; SNSA Rahman; S Ramanaidu; HA Rosdi; AA Mohamed Shariff; SW Shuit; NS Abdul Shukor; D Simatherai; A Sivapirakasam; CH Song; CS Tan; EZZ Tan; MH Tan; NH Tan; MK Tee; KM Thong; KU Tiong; J Vinathan; MZ Abdul Wahab; CM Wong; EFS Wong; HS Wong; JM Wong; A Hing; R Yahya; S Yakob; JGH Yap; SY Yee; KT Yong; M Zainon; WMK Wan Zainudin; AC Wong; SG Montoya Azpeitia; EA Bayram; C Chavez Del Bosque; RL Ceballos; Y Lozano Gonzalez; A Gutierrez; G Llamas Guitierrez; MJ Lara; GA Ruvalcaba Lopez; M Gonzalez Maldonado; L Gonzalez Morgado; CN Vidales Moctezuma; J Nava; E Pacheco; SF Avila Pardo; J Echeverri Rico; LG González Salas; A Cornejo Sanchez; S Irizar Santana; T Tellez; J Valente; M Contreras Varela; R Birne; A Alves; R Barata; S Barreto; P Branco; A Carnevale; F Teixeira E Costa; J Silva Costa; J Damas; D Domingos; R Escoli; S Fernandes; A Ferreira; F Ferrer; C Figueiredo; AR Martins; C Marouco; C Nicolau; F Nolasco; T Pereira; G Pimenta; F Rodrigues; M Roxo; J Silva; MP Simoes; H Vidal; V Dobronravov; T Abissova; N Antropenko; M Batiushin; O Blagoveschenskaya; N Bondarenko; N Bronovitskaya; E Chernyavskaya; M Danilova; T Elenskaya; S Eshmakov; A Ezhov; O Filatova; N Glotova; A Karunnaya; D Kilin; A Kupyanskaya; O Kuznetsova; L Kvitkova; E Levitskaya; N Odintsova; M Orlova; L Pimenov; A Razina; T Rodionova; T Savelieva; I Shashneva; A Solovieva; E Streltsova; N Tagintseva; M Vasiliev; N Yur; I Zadvorny; E Zhdanova; SC Yeo; GC Chan; HR Chua; YT Chua; Y Da; L Ealing; J Hsu; ZX Kog; JL Kwek; ESM Lim; A Liu; I Mok; C Ngoh; XY Ooi; SXJ Poh; HK Sran; SM Suhail; NC Tan; J Teo; W Weng; C Wong; E Wong; J An; TH Ban; J Cha; A Cho; BS Choi; DE Choi; S Eum; YR Ham; BG Han; KH Han; SY Han; SS Han; H Huh; HR Jang; JS Jeon; HY Jeong; CY Jung; SW Jung; YS Kang; Y Kee; BS Kim; DW Kim; DH Kim; H Kim; J Kim; J Kim; S Kim; TG Kim; YG Kim; YH Kim; YC Kim; Y Kim; H Lee; H Lee; J Lee; J Lee; JE Lee; J Lee; JP Lee; J Lee; KW Lee; SH Lee; SY Lee; Y Lee; YH Lee; YK Lee; JY Moon; KR Na; JE Oh; H Park; JY Park; JT Park; D Shin; SJ Shin; S Shin; C Silvain; Y Song; DH Yang; J Yang; HE Yoon; SJ Youn; MJ Soler; I Agraz; E Garrigos Almerich; A Lorenzo Almorós; F Arrojo Alonso; JC Primo Alvarez; I Rama Arias; E Calatayud Aristoy; M Azancot; A Tango Barrera; C Barrios; M Bolufer; H Bouarich; I Viejo Boyano; D Useros Branas; C Gilabert Brotons; B Gonzales Candia; LE Pérez Casares; B Vizcaino Castillo; C Castro; G Lopez Castellanos; LC Lopez; E Gimenez Civera; JM Cruzado; B Del Hoyo Cuenda; L D'Marco; F Martínez Debén; S Nunez Delagado; A Peris Domingo; J Bordignon Draibe; L Manzano Espinosa; L Fernandez; M Peris Fernandez; FM Frances; F Garcia; S Bermejo Garcia; LG D Marco Gascon; R Gimena; N Panizo Gonzalez; S Cigarrán Guldris; E Hernandez; J Hernandez Jaras; MP Liebana; A Cozar Llisto; P Llacer; M Lopez Martinez; J Mancha; P Martinez; E Morales; JJ Segura de la Morena; E Márquez Mosquera; M Gonzalez Moya; MJ Puchades Montesa; E Vivo Orti; RA Ruiz Ortega; A Oliveras; X Fulladosa Oliveras; JK Peña-Esparragoza; M Perez; J Pantoja Perez; P Bouza Piñeiro; E Perez Pison; A Juez Del Pozo; V Escudero Quesada; M Quero Ramos; N Ramos; JC Leon Roman; E Rodríguez; J Gorriz Teruel; N Toapanta; C Ramos Tomas; M Contreras Sanchez; L Sans; M Hueso Val; S Vázquez; CT Lee; CT Chang; DR Chang; FC Chang; MY Chang; YL Chang; CH Chao; CK Chan; CC Chen; CH Chen; HH Chen; KH Chen; TC Chen; YT Chen; HT Cheng; CK Chiang; WC Chiang; TY Chiou; CY Chou; PF Chiu; YL Chiu; YP Hsieh; HH Hsu; TM Huang; CC Hung; CC Jiang; JY Jiang; SW Ju; CC Kao; HL Kuo; CF Lai; TS Lai; CC Lee; WC Lee; LC Li; SY Lin; SL Lin; YC Lin; YS Peng; KH Shu; CC Tsai; SF Tsai; IK Wang; JS Wang; CL Wu; CY Wu; MJ Wu; VC Wu; CW Yang; HY Yang; JY Yang; SY Yang; YF Yang; Y Yang; WS Yang; TM Yu; K McCafferty; K Bramham; J Chong; T Cornish; T Doulton; C Farmer; S Griffin; C Hall; A Khwaja; M Leung; J Moriarty; T Pickett; S Saminathan; S Shah; N Shah; A Al Shami; A Shardlow; P Smith; M Wilkie; A Wonnacott; P Pergola; U Abdumomiov; I Agha; O Albajrami; M Aldahan; I Algantrani; R Alicic; S Alla; C Almanza; T Al-Tuhaifi; S Anand; AC Anatalio; F Arman; M Atta; A Awad; SN Babar; S Bansal; L Bantugan; A Barz; A Basford; JL Bates; S Beddhu; R Berenji; N Bhasin; M Bien; T Bjordahl; K Blackwood; E Bortequate; J Bruneau; N Bryant; W Bryant; AK Buckle; GN Buerkle; A Burgner; J Burgos; J Camacho; K Campbell; D Castrilla; I Castro-Revoredo; U Challa; A Chang; E Chang; L Cherem; WY Chiang; J Chittum; M Chonchol; M Chowdhury; C Christiano; C Chu; J Clark; S Clarke; S Collins; T Conger; J Connaire; RW Coomer; H Coore; P Crawford; Y DaCosta-Auld; N Dahl; M Das; A Davis; Y Deleon; M Diamond; J Manilo Dieck; B Dixon; M Dobre; N Dossabhoy; D Drew; C Duran-Martinez; S Elahi; V Espinoza; E Fels; P Fish; F Fleszler; N Freking; A Frome; C Gallego; P Garavaglia; B Garcia; I Garcia; R Goshtaseb; E Gould; ME Grant; R Gromala; A Gupta; M Hall; S Howard Ham; S Hamby; IJ Hanna; S Hanzl; AK Harlacher; M Hassanein; J Havill; K Hendon; J Herion; G Hernandez; D Highsmith; A Horeish; N Hristea; IL Hudson; T Hunkapiller; S Hussain; R Abu Hweij; T Idrees; R Indahyung; L Inker; S Iskapallim; J Jaffe; DI Jalal; A Jamal; D Jean-Louis; CS Jenkins; A Jovanovich; K Kalra; M Kamgar; S Kansal; MO Kaskas; J Kendrick; A Kennedy; S Khaleel; NA Khan; E Kirk; N Kopyt; W Kotzker; L Kupor; MP Law; I Leal; B Lee; RM Lustig; K Lyman; C Mack; G Maharjan; S Trevino Manilo; R Manllo-Karim; L Mayerson; N McCall; E McCarthy; C McClurkin; A Mehdi; R Mendez; J Meouchy; J Meyer; D Michaud; A Mirkhel; M Moghadam; D Mondero; R Moore; G Morell; A Mottl; J Moussa; RK Moussa; M Moustafa; MJ Mudry; R Nadella; O Naik; S Naila; G Nakhoul; T Nassar; L Negrea; G Newman; J Nguyen; N Nobakht; Y Obi; N Ogletree; M Olsen; K Ortiz; JG Owen; A Pacheco; A Padiyar; S Panse; B Paredes; J Partola; B Paueksakon; M Peevy; NN Perez; E Pierson; N Pradhan; R Pratley; L Preysner; P Pronovost; C Pysher; M Quadrini; R Quillman; D Rabideau; M Rahman; S Raissi; R Ralph; A Rashidi; A Rastogi; K Reaves; M Reed; M Reed; L Reid; K Reiner; S Reynolds; D Rhodes; H Richmond; SAA Rizvi; A Rizvi; A Rizvi; D Robinson; J Roesch; AM Romo; BP Ross; D Ross; M Salani; M Sandid; N Sarabu; M Sarkar; D Schmidt; A Schutt; T Shafi; L Short; K Shumburo; M Sika; K Simpson; MKM Siu; M Slayton; C Smith; M Smith; M Smith; K Solanki; J Soufer; D Speer; J Sperati; T Spinola; E Swoopes; J Taliercio; R Tanner; R Tasin; S Thaxton; T Thethi; G Thomas; S Tillman; MCYO Tio; J Tolins; J Turner; K Tuttle; SM Udani; K Umanath; G Umpierrez; A Valliant; J Vasallo; R Vigo-Vigo; A Wagner; M Walsh; G Wang; D Weiner; C Wells; K Matulonis Williams; B Williamson; K Wilt; C Wong; J Woodward; P Worthington; Z Yablon; O Yee; A Yue; RI Zabaneh; S Zaidi; JS Zbinden; HJL Heerspink; BL Neuen; R Agarwal; DZI Cherney; CSP Lam; KR Tuttle; C Warner; V Perkovic; GM Chertow; M Epstein; T Friede; A Levin; JFE Mann; JD Smeijer; N Jongs; M Brinker; N Li; N Rethemeier; D Burger; J Pawlitschko; K Mueller; J Reis; S Janitza; J Lay-Flurrie; P Schloemer; Y De Sanctis; C Ahlers; S Kuhls; M Figueras Balsells; C Scott; A Tuemer; C Klein; C Ellenberger; A Appana; M Shukla; S Thogari; M Bainaboyina; R Annapureddy; N Einfuehrer; R Neela; P Vesterinen; MY Finkelsztein; M Chen; J Augusto; C Serrano Redonnet; C Yamaguti; F Czekalla; J Sundaram; A Horvat-Broecker; D Goldsbury; J Disney; N Beakhouse; M Kusiak; N Richardson; D Alta; T Sadeoja; J Chen; L West; S Collamati; M Gregory; M Lombard; X Zhao; J Buytendach – Name: ChemicalData Label: Molecular Sequence Group: ChemData Data: ClinicalTrials.gov NCT05047263 – Name: NumberCAS Label: Substance Nomenclature Group: ID Data: DE2O63YV8R (finerenone)<br />0 (Mineralocorticoid Receptor Antagonists)<br />0 (Naphthyridines) – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260605 <i>Date Completed: </i>20260805 <i>Latest Revision: </i>20260910 – Name: DateUpdate Label: Update Code Group: Date Data: 20260910 – Name: DOI Label: DOI Group: ID Data: 10.1056/NEJMoa2604625 – Name: AN Label: PMID Group: ID Data: 42246672 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1056/NEJMoa2604625 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 533 Subjects: – SubjectFull: Glomerular Filtration Rate drug effects Type: general – SubjectFull: Mineralocorticoid Receptor Antagonists therapeutic use Type: general – SubjectFull: Mineralocorticoid Receptor Antagonists adverse effects Type: general – SubjectFull: Hyperkalemia chemically induced Type: general – SubjectFull: Hyperkalemia epidemiology Type: general – SubjectFull: Hospitalization statistics & numerical data Type: general – SubjectFull: Kidney Failure, Chronic epidemiology Type: general – SubjectFull: Kidney Failure, Chronic prevention & control Type: general – SubjectFull: Aged Type: general – SubjectFull: Female Type: general – SubjectFull: Humans Type: general – SubjectFull: Male Type: general – SubjectFull: Middle Aged Type: general – SubjectFull: Double-Blind Method Type: general – SubjectFull: Adult Type: general – SubjectFull: Treatment Outcome Type: general – SubjectFull: Albuminuria diagnosis Type: general – SubjectFull: Albuminuria drug therapy Type: general – SubjectFull: Cardiovascular Diseases etiology Type: general – SubjectFull: Cardiovascular Diseases mortality Type: general – SubjectFull: Cardiovascular Diseases prevention & control Type: general – SubjectFull: Naphthyridines adverse effects Type: general – SubjectFull: Naphthyridines therapeutic use Type: general – SubjectFull: Renal Insufficiency, Chronic complications Type: general – SubjectFull: Renal Insufficiency, Chronic diagnosis Type: general – SubjectFull: Renal Insufficiency, Chronic drug therapy Type: general – SubjectFull: Heart Failure epidemiology Type: general – SubjectFull: Heart Failure etiology Type: general – SubjectFull: Heart Failure prevention & control Type: general – SubjectFull: Heart Failure therapy Type: general Titles: – TitleFull: Finerenone in Persons with Chronic Kidney Disease without Diabetes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Heerspink HJL – PersonEntity: Name: NameFull: Neuen BL – PersonEntity: Name: NameFull: Agarwal R – PersonEntity: Name: NameFull: Cherney DZI – PersonEntity: Name: NameFull: Lam CSP – PersonEntity: Name: NameFull: Tuttle KR – PersonEntity: Name: NameFull: Wanner C – PersonEntity: Name: NameFull: Sarafidis P – PersonEntity: Name: NameFull: Jongs N – PersonEntity: Name: NameFull: Smeijer JD – PersonEntity: Name: NameFull: Brinker M – PersonEntity: Name: NameFull: Rethemeier N – PersonEntity: Name: NameFull: Schloemer P – PersonEntity: Name: NameFull: Vesterinen P – PersonEntity: Name: NameFull: Goldsbury D – PersonEntity: Name: NameFull: Dizayee S – PersonEntity: Name: NameFull: Mares JW – PersonEntity: Name: NameFull: Perkovic V IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 08 Text: 2026 Aug 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1533-4406 Numbering: – Type: volume Value: 395 – Type: issue Value: 6 Titles: – TitleFull: The New England journal of medicine Type: main |
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