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A model-based selection of oral cancer patient for passive scattering proton beam therapy.

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Τίτλος: A model-based selection of oral cancer patient for passive scattering proton beam therapy.
Συγγραφείς: Narita Y; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan., Takayama K; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan., Kato T; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.; Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima, Fukushima 960-8516, Japan., Komori S; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan., Seto I; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan., Nakasato T; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan., Murakami M; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.
Πηγή: Journal of radiation research [J Radiat Res] 2026 Jul 24; Vol. 67 (4), pp. 626-633.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376611 Publication Model: Print Cited Medium: Internet ISSN: 1349-9157 (Electronic) Linking ISSN: 04493060 NLM ISO Abbreviation: J Radiat Res Subsets: MEDLINE
Imprint Name(s): Publication: July 2012- : Oxford : Oxford University Press
Original Publication: Tokyo : Japan Radiation Research Society
Ιατρικοί όροι (MeSH): Proton Therapy*/adverse effects , Proton Therapy*/methods , Mouth Neoplasms*/radiotherapy , Scattering, Radiation* , Models, Biological*, Humans ; Female ; Male ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy Dosage ; Aged ; Middle Aged ; Radiotherapy, Intensity-Modulated
Περίληψη: Background and Purpose: To identify patients with oral cancer (OC) who benefit from proton therapy versus photon therapy using a model-based approach (MBA) to reduce late adverse events.
Material/methods: Passive scattering proton beam therapy (PSPT) and volumetric modulated arc therapy (VMAT) plans were established for 40 patients with OC, consisting of a dose of 70 Gy (relative biological effectiveness) in 35 fractions. At least 95% of the planning target volume received 95% of the prescribed dose, and the dose to the organs at risk was restricted to be as low as possible. Normal tissue complication probability (NTCP) was used to estimate the risk of late adverse events, including dysgeusia, xerostomia and osteoradionecrosis of the mandible. Patients who were considered as candidates for PSPT were selected if the NTCP difference between both plans (ΔNTCP) exceeded the threshold defined in the Dutch national indication protocol.
Results: PSPT reduced the doses to the spinal cord, pharynx, oral cavity and contralateral salivary glands compared with VMAT. PSPT was also superior for the risk evaluation of each late adverse event calculated by incorporating dose metrics and patient baseline risk factors. For the MBA using ΔNTCP and the thresholds, PSPT was indicated in 24 of the 40 cases, and the remaining 16 cases were considered to be equivalent to VMAT.
Conclusion: MBA was used to select OC cases that were candidates for PSPT. Compared with VMAT, the risk of expected late adverse events was significantly reduced with PSPT, and 60% of patients were considered eligible for PSPT.
(© The Author(s) 2026. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
References: Radiother Oncol. 2024 Jan;190:109812. (PMID: 37479061)
Cancer. 2000 Nov 15;89(10):2099-105. (PMID: 11066051)
Radiother Oncol. 2020 Oct;151:206-213. (PMID: 32768508)
Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):123-35. (PMID: 2032883)
Int J Radiat Oncol Biol Phys. 2021 Oct 1;111(2):549-558. (PMID: 33965514)
Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1165-1174. (PMID: 26194685)
Radiat Oncol. 2014 Sep 11;9:202. (PMID: 25212571)
Acta Otolaryngol. 2015 Sep;135(9):950-4. (PMID: 25925195)
Laryngoscope. 2013 Oct;123(10):2453-8. (PMID: 23553191)
Head Neck. 2016 Apr;38 Suppl 1:E2151-8. (PMID: 25735803)
Radiother Oncol. 2024 Jan;190:109958. (PMID: 37871751)
Radiother Oncol. 2023 Jul;184:109670. (PMID: 37059337)
Oral Oncol. 2018 Apr;79:71-77. (PMID: 29598953)
Radiother Oncol. 2012 Oct;105(1):101-6. (PMID: 22516776)
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):354-361. (PMID: 27473816)
Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1429-38. (PMID: 11286851)
Radiat Oncol. 2013 Jan 31;8:26. (PMID: 23369221)
Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):553-562. (PMID: 30625409)
Oral Maxillofac Surg Clin North Am. 2019 Feb;31(1):13-29. (PMID: 30454788)
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9. (PMID: 20171502)
Oral Oncol. 2009 Apr-May;45(4-5):394-401. (PMID: 18674952)
Med Phys. 2013 Aug;40(8):081709. (PMID: 23927306)
Radiother Oncol. 2011 Dec;101(3):376-82. (PMID: 21663988)
Radiat Oncol. 2022 Aug 26;17(1):150. (PMID: 36028862)
J Natl Cancer Inst. 1992 Feb 5;84(3):155-64. (PMID: 1311773)
Radiother Oncol. 2021 May;158:224-229. (PMID: 33667584)
J Healthc Eng. 2022 Apr 5;2022:4998997. (PMID: 35422981)
N Engl J Med. 2004 May 6;350(19):1945-52. (PMID: 15128894)
Semin Radiat Oncol. 2018 Apr;28(2):79-87. (PMID: 29735194)
Contributed Indexing: Keywords: model-based approach; oral cancer; proton beam therapy
Entry Date(s): Date Created: 20260604 Date Completed: 20260725 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13400572
DOI: 10.1093/jrr/rrag042
PMID: 42241327
Βάση Δεδομένων: MEDLINE
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  Data: A model-based selection of oral cancer patient for passive scattering proton beam therapy.
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  Data: <searchLink fieldCode="AU" term="%22Narita+Y%22">Narita Y</searchLink>; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.<br /><searchLink fieldCode="AU" term="%22Takayama+K%22">Takayama K</searchLink>; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+T%22">Kato T</searchLink>; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.; Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima, Fukushima 960-8516, Japan.<br /><searchLink fieldCode="AU" term="%22Komori+S%22">Komori S</searchLink>; Department of Radiation Physics and Technology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.<br /><searchLink fieldCode="AU" term="%22Seto+I%22">Seto I</searchLink>; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.<br /><searchLink fieldCode="AU" term="%22Nakasato+T%22">Nakasato T</searchLink>; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.<br /><searchLink fieldCode="AU" term="%22Murakami+M%22">Murakami M</searchLink>; Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, 7-172 Yatsuyamada, Koriyama, Fukushima 963-8052, Japan.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Purpose: To identify patients with oral cancer (OC) who benefit from proton therapy versus photon therapy using a model-based approach (MBA) to reduce late adverse events.<br />Material/methods: Passive scattering proton beam therapy (PSPT) and volumetric modulated arc therapy (VMAT) plans were established for 40 patients with OC, consisting of a dose of 70 Gy (relative biological effectiveness) in 35 fractions. At least 95% of the planning target volume received 95% of the prescribed dose, and the dose to the organs at risk was restricted to be as low as possible. Normal tissue complication probability (NTCP) was used to estimate the risk of late adverse events, including dysgeusia, xerostomia and osteoradionecrosis of the mandible. Patients who were considered as candidates for PSPT were selected if the NTCP difference between both plans (ΔNTCP) exceeded the threshold defined in the Dutch national indication protocol.<br />Results: PSPT reduced the doses to the spinal cord, pharynx, oral cavity and contralateral salivary glands compared with VMAT. PSPT was also superior for the risk evaluation of each late adverse event calculated by incorporating dose metrics and patient baseline risk factors. For the MBA using ΔNTCP and the thresholds, PSPT was indicated in 24 of the 40 cases, and the remaining 16 cases were considered to be equivalent to VMAT.<br />Conclusion: MBA was used to select OC cases that were candidates for PSPT. Compared with VMAT, the risk of expected late adverse events was significantly reduced with PSPT, and 60% of patients were considered eligible for PSPT.<br /> (© The Author(s) 2026. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Radiother Oncol. 2024 Jan;190:109812. (PMID: <searchLink fieldCode="PM" term="%2237479061%22">37479061)</searchLink><br />Cancer. 2000 Nov 15;89(10):2099-105. (PMID: <searchLink fieldCode="PM" term="%2211066051%22">11066051)</searchLink><br />Radiother Oncol. 2020 Oct;151:206-213. (PMID: <searchLink fieldCode="PM" term="%2232768508%22">32768508)</searchLink><br />Int J Radiat Oncol Biol Phys. 1991 May 15;21(1):123-35. (PMID: <searchLink fieldCode="PM" term="%222032883%22">2032883)</searchLink><br />Int J Radiat Oncol Biol Phys. 2021 Oct 1;111(2):549-558. (PMID: <searchLink fieldCode="PM" term="%2233965514%22">33965514)</searchLink><br />Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1165-1174. (PMID: <searchLink fieldCode="PM" term="%2226194685%22">26194685)</searchLink><br />Radiat Oncol. 2014 Sep 11;9:202. (PMID: <searchLink fieldCode="PM" term="%2225212571%22">25212571)</searchLink><br />Acta Otolaryngol. 2015 Sep;135(9):950-4. (PMID: <searchLink fieldCode="PM" term="%2225925195%22">25925195)</searchLink><br />Laryngoscope. 2013 Oct;123(10):2453-8. (PMID: <searchLink fieldCode="PM" term="%2223553191%22">23553191)</searchLink><br />Head Neck. 2016 Apr;38 Suppl 1:E2151-8. (PMID: <searchLink fieldCode="PM" term="%2225735803%22">25735803)</searchLink><br />Radiother Oncol. 2024 Jan;190:109958. (PMID: <searchLink fieldCode="PM" term="%2237871751%22">37871751)</searchLink><br />Radiother Oncol. 2023 Jul;184:109670. (PMID: <searchLink fieldCode="PM" term="%2237059337%22">37059337)</searchLink><br />Oral Oncol. 2018 Apr;79:71-77. (PMID: <searchLink fieldCode="PM" term="%2229598953%22">29598953)</searchLink><br />Radiother Oncol. 2012 Oct;105(1):101-6. (PMID: <searchLink fieldCode="PM" term="%2222516776%22">22516776)</searchLink><br />Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):354-361. (PMID: <searchLink fieldCode="PM" term="%2227473816%22">27473816)</searchLink><br />Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1429-38. (PMID: <searchLink fieldCode="PM" term="%2211286851%22">11286851)</searchLink><br />Radiat Oncol. 2013 Jan 31;8:26. (PMID: <searchLink fieldCode="PM" term="%2223369221%22">23369221)</searchLink><br />Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):553-562. (PMID: <searchLink fieldCode="PM" term="%2230625409%22">30625409)</searchLink><br />Oral Maxillofac Surg Clin North Am. 2019 Feb;31(1):13-29. (PMID: <searchLink fieldCode="PM" term="%2230454788%22">30454788)</searchLink><br />Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9. (PMID: <searchLink fieldCode="PM" term="%2220171502%22">20171502)</searchLink><br />Oral Oncol. 2009 Apr-May;45(4-5):394-401. (PMID: <searchLink fieldCode="PM" term="%2218674952%22">18674952)</searchLink><br />Med Phys. 2013 Aug;40(8):081709. (PMID: <searchLink fieldCode="PM" term="%2223927306%22">23927306)</searchLink><br />Radiother Oncol. 2011 Dec;101(3):376-82. (PMID: <searchLink fieldCode="PM" term="%2221663988%22">21663988)</searchLink><br />Radiat Oncol. 2022 Aug 26;17(1):150. (PMID: <searchLink fieldCode="PM" term="%2236028862%22">36028862)</searchLink><br />J Natl Cancer Inst. 1992 Feb 5;84(3):155-64. (PMID: <searchLink fieldCode="PM" term="%221311773%22">1311773)</searchLink><br />Radiother Oncol. 2021 May;158:224-229. (PMID: <searchLink fieldCode="PM" term="%2233667584%22">33667584)</searchLink><br />J Healthc Eng. 2022 Apr 5;2022:4998997. (PMID: <searchLink fieldCode="PM" term="%2235422981%22">35422981)</searchLink><br />N Engl J Med. 2004 May 6;350(19):1945-52. (PMID: <searchLink fieldCode="PM" term="%2215128894%22">15128894)</searchLink><br />Semin Radiat Oncol. 2018 Apr;28(2):79-87. (PMID: <searchLink fieldCode="PM" term="%2229735194%22">29735194)</searchLink>
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