Academic Journal
Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.
| Τίτλος: | Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial. |
|---|---|
| Συγγραφείς: | Østergaard AM; University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark., Rosenbæk JB; University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark., Ejlersen JA; Department of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark., Mose FH; University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark., Bech JN; University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark., Vrist MH; University Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark. |
| Πηγή: | Physiological reports [Physiol Rep] 2026 Jun; Vol. 14 (11), pp. e70919. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
| Ιατρικοί όροι (MeSH): | Nitrates*/pharmacology , Nitrates*/administration & dosage , Natriuresis*/drug effects , Sodium*/urine , Sodium*/metabolism , Potassium Compounds*/pharmacology , Potassium Compounds*/administration & dosage , Saline Solution*/administration & dosage , Kidney*/drug effects , Kidney*/metabolism, Cyclic GMP/blood ; Nitric Oxide/blood ; Blood Pressure/drug effects ; Humans ; Cross-Over Studies ; Male ; Female ; Adult ; Double-Blind Method ; Young Adult |
| Περίληψη: | Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests increased NO promotes natriuresis, whereas inorganic nitrate studies remain inconclusive. We conducted a randomized, double-blind, placebo-controlled crossover trial in 18 healthy adults, with 4 days of potassium nitrate (KNO (© 2026 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
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| Contributed Indexing: | Keywords: arginine vasopressin; hemodynamic; inorganic nitrate; nitric oxide; renal sodium excretion; saline loading |
| Substance Nomenclature: | 0 (Nitrates) H2D2X058MU (Cyclic GMP) 9NEZ333N27 (Sodium) RU45X2JN0Z (potassium nitrate) 0 (Potassium Compounds) 31C4KY9ESH (Nitric Oxide) 0 (Saline Solution) |
| Entry Date(s): | Date Created: 20260604 Date Completed: 20260610 Latest Revision: 20260918 |
| Update Code: | 20260918 |
| PubMed Central ID: | PMC13581089 |
| DOI: | 10.14814/phy2.70919 |
| PMID: | 42237694 |
| Βάση Δεδομένων: | MEDLINE |
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