Academic Journal
Efficiently electron beam radiation-induced degradation and extraction of Angelica sinensis polysaccharides and its excellent biofunctional properties.
| Title: | Efficiently electron beam radiation-induced degradation and extraction of Angelica sinensis polysaccharides and its excellent biofunctional properties. |
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| Authors: | Hu Y; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China., Liu X; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China., Wang H; Gansu Puankang Pharmaceutical Co., Ltd., Lanzhou 730207, China., Xin Z; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China., Chen F; State Nuclear Security Technology Center, Beijing 102401, China., Hu F; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China., Liu B; Gansu Puankang Pharmaceutical Co., Ltd., Lanzhou 730207, China., Lu X; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China., Du M; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China., Ren X; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China., Wang Z; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China., Li X; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: lixh@impcas.ac.cn., Yang A; School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China. Electronic address: yangam@lut.edu.cn., Zhou L; Biophysics Group, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 101408, China; State Key Laboratory of Heavy Ion Science and Technology, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China. Electronic address: libinzhou@impcas.ac.cn. |
| Source: | Food chemistry [Food Chem] 2026 Aug 30; Vol. 521, pp. 149896. Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Elsevier Applied Science Publishers Original Publication: Barking, Eng., Applied Science Publishers. |
| MeSH Terms: | Angelica sinensis*/chemistry , Angelica sinensis*/radiation effects , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Polysaccharides*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification, Antioxidants/chemistry ; Antioxidants/pharmacology ; Antioxidants/isolation & purification ; Humans ; Electrons ; Molecular Weight ; K562 Cells ; Animals |
| Abstract: | The full exploitation of botanical polysaccharides is often hampered by inefficient extraction and limited structural controllability. This study investigated electron beam irradiation (EBI, 0-80 kGy) as a green pretreatment to enhance extraction yield and modify biofunctional properties of Angelica sinensis polysaccharides. EBI enhanced extraction yield by 62.13%, while reducing molecular weight by 46.61%, enhancing solubility and oil holding capacity. Notably, EBI triggered a dose-dependent reconstruction of monosaccharide composition, including a 42.01% increase in arabinose, without altering the fundamental functional groups or triple-helix conformation. This structural modulation led to divergent functional enhancements, medium-dose irradiation (40 kGy) markedly improved immunomodulatory activity and foaming capacity/stability, whereas high-dose irradiation (80 kGy) greatly enhanced antioxidant activity and antitumor efficacy against K562 cells. The strong correlations established between structural parameters and bioactivities underscore a controllable structure-activity relationship. These findings provide a novel strategy for the value-added development of functional food ingredients. (Copyright © 2024. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Angelica sinensis polysaccharides; Biofunctional properties; Degradation; Electron beam irradiation; Extraction |
| Substance Nomenclature: | 0 (Polysaccharides) 0 (Antioxidants) 0 (Plant Extracts) |
| Entry Date(s): | Date Created: 20260603 Date Completed: 20260703 Latest Revision: 20260703 |
| Update Code: | 20260703 |
| DOI: | 10.1016/j.foodchem.2026.149896 |
| PMID: | 42235228 |
| Database: | MEDLINE |
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