Academic Journal
Postoperative quality of life and nutritional outcomes following subtotal, proximal, or distal gastrectomy for upper gastric cancer: a retrospective cohort study.
| Τίτλος: | Postoperative quality of life and nutritional outcomes following subtotal, proximal, or distal gastrectomy for upper gastric cancer: a retrospective cohort study. |
|---|---|
| Συγγραφείς: | Okubo K; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Arigami T; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. arigami@m.kufm.kagoshima-u.ac.jp., Shimonosono M; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Matsushita D; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Sasaki K; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Noda M; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Baba K; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Kawasaki Y; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan., Ohtsuka T; Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. |
| Πηγή: | Surgery today [Surg Today] 2026 Oct; Vol. 56 (10), pp. 2149-2157. Date of Electronic Publication: 2026 Jun 03. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer International Country of Publication: Japan NLM ID: 9204360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-2813 (Electronic) Linking ISSN: 09411291 NLM ISO Abbreviation: Surg Today Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tokyo : Springer International, c1992- |
| Ιατρικοί όροι (MeSH): | Stomach Neoplasms*/surgery , Stomach Neoplasms*/pathology , Stomach Neoplasms*/physiopathology , Gastrectomy*/methods , Quality of Life* , Nutritional Status*, Humans ; Retrospective Studies ; Female ; Male ; Treatment Outcome ; Aged ; Middle Aged ; Postoperative Period ; Cohort Studies ; Neoplasm Staging ; Postgastrectomy Syndromes ; Postoperative Complications |
| Περίληψη: | Purpose: The optimal surgical approach for upper gastric cancer remains controversial, particularly regarding the postoperative quality of life (QOL) and nutritional outcomes. This study compared the outcomes of subtotal gastrectomy (STG), proximal gastrectomy (PG), and distal gastrectomy (DG). Methods: We retrospectively analyzed 94 patients who underwent gastrectomy for upper gastric cancer (DG: n = 39, PG: n = 33, STG: n = 22). The quality of life (QOL) was assessed using the Postgastrectomy Syndrome Assessment Scale (PGSAS-45) 12 months postoperatively. The nutritional status was evaluated based on changes in body weight. Results: The baseline clinicopathological factors and TNM stages were comparable among the three cohorts. PG was associated with significantly worse reflux, dyspepsia, and meal-related complaints than STG and DG. The STG showed fewer dumping-related symptoms than the PG. No significant differences in overall nutritional status were observed between the STG and DG groups, whereas the PG group tended to be associated with less favorable nutritional outcomes. These findings were consistent with the responder analyses. Conclusions: In this retrospective cohort study, STG was associated with a more favorable postoperative symptom profile than PG and showed postoperative outcomes comparable to those of DG. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: Takaaki Arigami has received lecture fees from Astellas, Eli Lilly, Bristol-Myers-Squibb, and Daiichi Sankyo, Japan. The other authors declare no conflict of interest. Ethics statements: All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. This study was approved by the Institutional Review Board of Kagoshima University (approval number: 230068), and all patients provided written informed consent for the use of their information. This retrospective study used the “opt-out” method to obtain informed consent from patients. |
| References: | World J Gastroenterol. 2015 Mar 14;21(10):3093-9. (PMID: 25780310) Anticancer Res. 2024 Jan;44(1):387-396. (PMID: 38159990) Gastric Cancer. 2016 Jan;19(1):302-11. (PMID: 25637175) Gastric Cancer. 2015 Apr;18(2):397-406. (PMID: 24760336) Ann Surg Oncol. 2013 Aug;20(8):2683-92. (PMID: 23504120) Gastric Cancer. 2015 Apr;18(2):407-16. (PMID: 24801198) J Gastric Cancer. 2020 Jun;20(2):176-189. (PMID: 32596001) Surg Today. 2022 May;52(5):832-843. (PMID: 34734320) Gastric Cancer. 2011 Jun;14(2):194-9. (PMID: 21347820) Surg Today. 2023 Feb;53(2):182-191. (PMID: 35778566) World J Surg. 2014 Dec;38(12):3152-62. (PMID: 25135173) Gastric Cancer. 2020 Jul;23(4):746-753. (PMID: 32086650) Gastric Cancer. 2018 May;21(3):500-507. (PMID: 28825149) Nihon Geka Gakkai Zasshi. 1984 Sep;85(9):1001-5. (PMID: 6438478) Gastric Cancer. 2019 Sep;22(5):1060-1068. (PMID: 30830641) Ann Surg Oncol. 2014 Jun;21 Suppl 3:S370-8. (PMID: 24590434) J Gastric Cancer. 2023 Apr;23(2):303-314. (PMID: 37129154) Ann Gastroenterol Surg. 2024 Aug 28;9(1):89-97. (PMID: 39759986) Ann Gastroenterol Surg. 2021 Dec 15;6(3):355-365. (PMID: 35634182) Surg Today. 2025 Feb;55(2):162-171. (PMID: 38904882) JAMA Netw Open. 2021 Mar 1;4(3):e211840. (PMID: 33729506) Ann Gastroenterol Surg. 2025 Jan 24;9(4):650-657. (PMID: 40607282) Front Oncol. 2022 Dec 15;12:1000719. (PMID: 36591467) Gastric Cancer. 2019 Sep;22(5):999-1008. (PMID: 30788750) Surg Endosc. 2017 Nov;31(11):4631-4640. (PMID: 28389797) CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. (PMID: 21296855) Ann Surg Oncol. 2014 Jun;21(6):2028-35. (PMID: 24558062) Ann Gastroenterol Surg. 2021 Jan 27;5(3):278-286. (PMID: 34095717) Gastric Cancer. 2015 Jan;18(1):147-58. (PMID: 24515247) Cancers (Basel). 2023 Jan 03;15(1):. (PMID: 36612308) World J Gastroenterol. 2017 Mar 21;23(11):2068-2076. (PMID: 28373774) World J Gastroenterol. 2020 Nov 21;26(43):6837-6852. (PMID: 33268965) |
| Contributed Indexing: | Keywords: Distal gastrectomy; Nutritional outcomes; Postoperative quality of life; Proximal gastrectomy; Subtotal gastrectomy; Upper gastric cancer |
| Entry Date(s): | Date Created: 20260603 Date Completed: 20260909 Latest Revision: 20260912 |
| Update Code: | 20260912 |
| PubMed Central ID: | PMC13558340 |
| DOI: | 10.1007/s00595-026-03337-6 |
| PMID: | 42234143 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!