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Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits.

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Τίτλος: Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits.
Συγγραφείς: Lu J; Department of Orthopedics, Genertec Universal Xi'an Aero-Engine Hospital, Xi'an, Shaanxi, China., Hu Y; Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, Gansu, China., Yao X; Department of Day Surgery Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Πηγή: Animal models and experimental medicine [Animal Model Exp Med] 2026 Jul; Vol. 9 (7), pp. 1480-1486. Date of Electronic Publication: 2026 Jun 01.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101726292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-2095 (Electronic) Linking ISSN: 25762095 NLM ISO Abbreviation: Animal Model Exp Med Subsets: MEDLINE
Imprint Name(s): Original Publication: [Hoboken, New Jersey] : John Wiley & Sons, Inc., [2018]-
Ιατρικοί όροι (MeSH): Spinal Fusion*/methods , Models, Animal*, Lumbar Vertebrae/surgery ; Intervertebral Disc/surgery ; Spine/surgery ; Animals ; Rabbits ; Rats ; Mice ; Male ; Rats, Sprague-Dawley ; Female ; Disease Models, Animal ; Species Specificity
Περίληψη: This study aims to establish a theoretical foundation for selecting and constructing animal models in clinical research on spine-related diseases. By establishing surgical models in three experimental animal species-mice, rats, and rabbits-we compare their respective advantages and disadvantages. First, three experimental animals of each of the three species were selected in good health. Subsequently, the experimental animals were dissected and several indices of the designated intervertebral discs and the height of the adjacent vertebrae were measured. At the same time, the ease of the surgical operation was assessed intraoperatively (in terms of the ease of preoperative localization, the clarity of the intraoperative structures, and the length of the surgical operation). In addition, the animal type most suitable for the construction of a spinal fusion surgery model was evaluated. Finally, a rabbit spinal fusion surgical model was constructed and evaluated by palpation and gross view of the tissue to assess the degree of spinal fusion. The data on the disc structure of rabbits have more advantages than those of mice and rats in constructing surgical models, with easier preoperative localization, more precise intraoperative structure, and shorter surgery time. Spinal fusion surgery in rabbits was successful, with a significant trend toward fusion at 4 weeks postoperatively. Rabbits were superior to mice and rats as experimental animals for establishing spinal fusion surgery models, and the fusion models were effective.
(© 2026 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.)
References: JOR Spine. 2020 Dec 23;4(1):e1135. (PMID: 33778408)
J Bone Joint Surg Am. 2024 Apr 17;106(8):735-745. (PMID: 38194481)
Spine (Phila Pa 1976). 2024 Sep 1;49(17):1179-1186. (PMID: 38213106)
J Orthop Translat. 2022 Nov 15;38:167-174. (PMID: 36439630)
Biomater Sci. 2020 Aug 7;8(15):4147-4156. (PMID: 32496502)
Sci Adv. 2021 Jun 11;7(24):. (PMID: 34117071)
J Bone Joint Surg Am. 2021 Aug 18;103(16):e64. (PMID: 33950879)
J Spine Surg. 2019 Jun;5(2):215-222. (PMID: 31380475)
PLoS One. 2012;7(12):e52910. (PMID: 23300816)
Front Vet Sci. 2023 Jun 26;10:1208593. (PMID: 37434865)
Spine (Phila Pa 1976). 2022 Apr 1;47(7):E319-E327. (PMID: 34593736)
J Invest Surg. 2017 Aug;30(4):226-234. (PMID: 27739917)
Biomaterials. 2004 Apr;25(9):1475-85. (PMID: 14697850)
Spine (Phila Pa 1976). 1996 Nov 15;21(22):2689-97. (PMID: 8961457)
Bioact Mater. 2022 Nov 16;23:234-246. (PMID: 36439084)
Lab Invest. 2022 Mar;102(3):312-319. (PMID: 34764437)
Neurochirurgie. 2023 May;69(3):101428. (PMID: 36871885)
Spine J. 2005 Nov-Dec;5(6 Suppl):209S-216S. (PMID: 16291115)
J Orthop Translat. 2020 Sep 14;26:151-161. (PMID: 33437634)
Ann Biomed Eng. 2016 Nov;44(11):3186-3201. (PMID: 27473706)
Vet Surg. 2019 Oct;48(7):1287-1298. (PMID: 31441092)
Int J Mol Sci. 2023 Jan 03;24(1):. (PMID: 36614335)
JOR Spine. 2021 Jul 02;4(3):e1166. (PMID: 34611589)
Spine J. 2020 Feb;20(2):300-306. (PMID: 31377475)
Contributed Indexing: Keywords: Lα intervertebral disc; mice; operation; rabbit; rat; spinal fusion surgery model
Entry Date(s): Date Created: 20260602 Date Completed: 20260730 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13394922
DOI: 10.1002/ame2.70215
PMID: 42226571
Βάση Δεδομένων: MEDLINE
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  Data: Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits.
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  Data: <searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Orthopedics, Genertec Universal Xi'an Aero-Engine Hospital, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, Gansu, China.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Department of Day Surgery Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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  Data: <searchLink fieldCode="JN" term="%22101726292%22">Animal models and experimental medicine</searchLink> [Animal Model Exp Med] 2026 Jul; Vol. 9 (7), pp. 1480-1486. <i>Date of Electronic Publication: </i>2026 Jun 01.
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  Data: This study aims to establish a theoretical foundation for selecting and constructing animal models in clinical research on spine-related diseases. By establishing surgical models in three experimental animal species-mice, rats, and rabbits-we compare their respective advantages and disadvantages. First, three experimental animals of each of the three species were selected in good health. Subsequently, the experimental animals were dissected and several indices of the designated intervertebral discs and the height of the adjacent vertebrae were measured. At the same time, the ease of the surgical operation was assessed intraoperatively (in terms of the ease of preoperative localization, the clarity of the intraoperative structures, and the length of the surgical operation). In addition, the animal type most suitable for the construction of a spinal fusion surgery model was evaluated. Finally, a rabbit spinal fusion surgical model was constructed and evaluated by palpation and gross view of the tissue to assess the degree of spinal fusion. The data on the disc structure of rabbits have more advantages than those of mice and rats in constructing surgical models, with easier preoperative localization, more precise intraoperative structure, and shorter surgery time. Spinal fusion surgery in rabbits was successful, with a significant trend toward fusion at 4 weeks postoperatively. Rabbits were superior to mice and rats as experimental animals for establishing spinal fusion surgery models, and the fusion models were effective.<br /> (© 2026 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.)
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  Data: JOR Spine. 2020 Dec 23;4(1):e1135. (PMID: <searchLink fieldCode="PM" term="%2233778408%22">33778408)</searchLink><br />J Bone Joint Surg Am. 2024 Apr 17;106(8):735-745. (PMID: <searchLink fieldCode="PM" term="%2238194481%22">38194481)</searchLink><br />Spine (Phila Pa 1976). 2024 Sep 1;49(17):1179-1186. (PMID: <searchLink fieldCode="PM" term="%2238213106%22">38213106)</searchLink><br />J Orthop Translat. 2022 Nov 15;38:167-174. (PMID: <searchLink fieldCode="PM" term="%2236439630%22">36439630)</searchLink><br />Biomater Sci. 2020 Aug 7;8(15):4147-4156. (PMID: <searchLink fieldCode="PM" term="%2232496502%22">32496502)</searchLink><br />Sci Adv. 2021 Jun 11;7(24):. (PMID: <searchLink fieldCode="PM" term="%2234117071%22">34117071)</searchLink><br />J Bone Joint Surg Am. 2021 Aug 18;103(16):e64. (PMID: <searchLink fieldCode="PM" term="%2233950879%22">33950879)</searchLink><br />J Spine Surg. 2019 Jun;5(2):215-222. (PMID: <searchLink fieldCode="PM" term="%2231380475%22">31380475)</searchLink><br />PLoS One. 2012;7(12):e52910. (PMID: <searchLink fieldCode="PM" term="%2223300816%22">23300816)</searchLink><br />Front Vet Sci. 2023 Jun 26;10:1208593. (PMID: <searchLink fieldCode="PM" term="%2237434865%22">37434865)</searchLink><br />Spine (Phila Pa 1976). 2022 Apr 1;47(7):E319-E327. (PMID: <searchLink fieldCode="PM" term="%2234593736%22">34593736)</searchLink><br />J Invest Surg. 2017 Aug;30(4):226-234. (PMID: <searchLink fieldCode="PM" term="%2227739917%22">27739917)</searchLink><br />Biomaterials. 2004 Apr;25(9):1475-85. (PMID: <searchLink fieldCode="PM" term="%2214697850%22">14697850)</searchLink><br />Spine (Phila Pa 1976). 1996 Nov 15;21(22):2689-97. (PMID: <searchLink fieldCode="PM" term="%228961457%22">8961457)</searchLink><br />Bioact Mater. 2022 Nov 16;23:234-246. (PMID: <searchLink fieldCode="PM" term="%2236439084%22">36439084)</searchLink><br />Lab Invest. 2022 Mar;102(3):312-319. (PMID: <searchLink fieldCode="PM" term="%2234764437%22">34764437)</searchLink><br />Neurochirurgie. 2023 May;69(3):101428. (PMID: <searchLink fieldCode="PM" term="%2236871885%22">36871885)</searchLink><br />Spine J. 2005 Nov-Dec;5(6 Suppl):209S-216S. (PMID: <searchLink fieldCode="PM" term="%2216291115%22">16291115)</searchLink><br />J Orthop Translat. 2020 Sep 14;26:151-161. (PMID: <searchLink fieldCode="PM" term="%2233437634%22">33437634)</searchLink><br />Ann Biomed Eng. 2016 Nov;44(11):3186-3201. (PMID: <searchLink fieldCode="PM" term="%2227473706%22">27473706)</searchLink><br />Vet Surg. 2019 Oct;48(7):1287-1298. (PMID: <searchLink fieldCode="PM" term="%2231441092%22">31441092)</searchLink><br />Int J Mol Sci. 2023 Jan 03;24(1):. (PMID: <searchLink fieldCode="PM" term="%2236614335%22">36614335)</searchLink><br />JOR Spine. 2021 Jul 02;4(3):e1166. (PMID: <searchLink fieldCode="PM" term="%2234611589%22">34611589)</searchLink><br />Spine J. 2020 Feb;20(2):300-306. (PMID: <searchLink fieldCode="PM" term="%2231377475%22">31377475)</searchLink>
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  Data: <i>Keywords: </i>Lα intervertebral disc; mice; operation; rabbit; rat; spinal fusion surgery model
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        Text: English
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    Subjects:
      – SubjectFull: Lumbar Vertebrae surgery
        Type: general
      – SubjectFull: Intervertebral Disc surgery
        Type: general
      – SubjectFull: Spine surgery
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Rabbits
        Type: general
      – SubjectFull: Rats
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      – SubjectFull: Disease Models, Animal
        Type: general
      – SubjectFull: Species Specificity
        Type: general
      – SubjectFull: Spinal Fusion methods
        Type: general
      – SubjectFull: Models, Animal
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      – TitleFull: Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits.
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              Text: 2026 Jul
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