Academic Journal
The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis.
| Title: | The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis. |
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| Authors: | Sabourian A; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran., Vahidi B; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran. |
| Source: | Biomedical physics & engineering express [Biomed Phys Eng Express] 2026 Jun 10; Vol. 12 (3). Date of Electronic Publication: 2026 Jun 10. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol : IOP Publishing Ltd., [2015]- |
| MeSH Terms: | Action Potentials*/physiology , Diffusion Magnetic Resonance Imaging*/methods , Neurons*/physiology , Neurons*/cytology , Hippocampus*/cytology , Hippocampus*/physiology , Cytoplasmic Streaming*/physiology , Models, Neurological*, Animals ; Computer Simulation ; Diffusion |
| Abstract: | Diffusion MRI relies greatly on the apparent diffusion coefficient (ADC) as a key indicator of tissue microstructure, yet the way and the extent to which intracellular dynamics influence it remains elusive. In this work the role of cytoplasmic streaming induced by neuronal activity on ADC in neural cells was investigated. A hippocampal neuron was modeled and the effect of the forces generated by action potential (AP) streaming were numerically simulated. Coupling Navier-Stokes equations with elastic solid equations and AP forces enabled us to obtain the generated intracellular flow which then was used in transport equations to calculate concentration of the diffusion propagator and its variance over the computational domain. A significant increase of 27% in ADC was observed at AP firing frequency of 200 Hertz. Furthermore, this enhancement increases quasi-linearly with frequency. This work demonstrates that the effect of AP-and the subsequent generated intracellular flow-on ADC is non-negligible; therefore, disturbing AP firing can result in a reduction in measured ADC values. These findings could improve the current understanding of ADC reduction under pathological conditions and lay a foundation for future studies on this topic. (© 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.) |
| Contributed Indexing: | Keywords: ADC; DWI; diffusion; intracellular streaming; numerical simulation |
| Entry Date(s): | Date Created: 20260601 Date Completed: 20260610 Latest Revision: 20260924 |
| Update Code: | 20260925 |
| DOI: | 10.1088/2057-1976/ae7576 |
| PMID: | 42225124 |
| Database: | MEDLINE |
| ISSN: | 2057-1976 |
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| DOI: | 10.1088/2057-1976/ae7576 |