Academic Journal
Προβολή σε EDS

The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis.
Συγγραφείς: Sabourian A; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran., Vahidi B; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran.
Πηγή: Biomedical physics & engineering express [Biomed Phys Eng Express] 2026 Jun 10; Vol. 12 (3). Date of Electronic Publication: 2026 Jun 10.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE
Imprint Name(s): Original Publication: Bristol : IOP Publishing Ltd., [2015]-
Ιατρικοί όροι (MeSH): Action Potentials*/physiology , Diffusion Magnetic Resonance Imaging*/methods , Neurons*/physiology , Neurons*/cytology , Hippocampus*/cytology , Hippocampus*/physiology , Cytoplasmic Streaming*/physiology , Models, Neurological*, Animals ; Computer Simulation ; Diffusion
Περίληψη: Diffusion MRI relies greatly on the apparent diffusion coefficient (ADC) as a key indicator of tissue microstructure, yet the way and the extent to which intracellular dynamics influence it remains elusive. In this work the role of cytoplasmic streaming induced by neuronal activity on ADC in neural cells was investigated. A hippocampal neuron was modeled and the effect of the forces generated by action potential (AP) streaming were numerically simulated. Coupling Navier-Stokes equations with elastic solid equations and AP forces enabled us to obtain the generated intracellular flow which then was used in transport equations to calculate concentration of the diffusion propagator and its variance over the computational domain. A significant increase of 27% in ADC was observed at AP firing frequency of 200 Hertz. Furthermore, this enhancement increases quasi-linearly with frequency. This work demonstrates that the effect of AP-and the subsequent generated intracellular flow-on ADC is non-negligible; therefore, disturbing AP firing can result in a reduction in measured ADC values. These findings could improve the current understanding of ADC reduction under pathological conditions and lay a foundation for future studies on this topic.
(© 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)
Contributed Indexing: Keywords: ADC; DWI; diffusion; intracellular streaming; numerical simulation
Entry Date(s): Date Created: 20260601 Date Completed: 20260610 Latest Revision: 20260924
Update Code: 20260925
DOI: 10.1088/2057-1976/ae7576
PMID: 42225124
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
Header DbId: cmedm
DbLabel: MEDLINE
An: 42225124
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sabourian+A%22">Sabourian A</searchLink>; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Vahidi+B%22">Vahidi B</searchLink>; Department of Medical Technology and Tissue Engineering, Faculty of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101675002%22">Biomedical physics & engineering express</searchLink> [Biomed Phys Eng Express] 2026 Jun 10; Vol. 12 (3). <i>Date of Electronic Publication: </i>2026 Jun 10.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22IOP+Publishing+Ltd%22">IOP Publishing Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101675002 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2057-1976 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220571976%22">20571976 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Phys Eng Express <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Original Publication</i>: Bristol : IOP Publishing Ltd., [2015]-
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Action+Potentials%22">Action Potentials*</searchLink>/<searchLink fieldCode="MM" term="%22Action+Potentials+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Diffusion+Magnetic+Resonance+Imaging%22">Diffusion Magnetic Resonance Imaging*</searchLink>/<searchLink fieldCode="MM" term="%22Diffusion+Magnetic+Resonance+Imaging+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Neurons%22">Neurons*</searchLink>/<searchLink fieldCode="MM" term="%22Neurons+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Neurons%22">Neurons*</searchLink>/<searchLink fieldCode="MM" term="%22Neurons+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hippocampus%22">Hippocampus*</searchLink>/<searchLink fieldCode="MM" term="%22Hippocampus+cytology%22">cytology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hippocampus%22">Hippocampus*</searchLink>/<searchLink fieldCode="MM" term="%22Hippocampus+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Cytoplasmic+Streaming%22">Cytoplasmic Streaming*</searchLink>/<searchLink fieldCode="MM" term="%22Cytoplasmic+Streaming+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Models%2C+Neurological%22">Models, Neurological*</searchLink><br /><searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Computer+Simulation%22">Computer Simulation</searchLink> ; <searchLink fieldCode="MH" term="%22Diffusion%22">Diffusion</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Diffusion MRI relies greatly on the apparent diffusion coefficient (ADC) as a key indicator of tissue microstructure, yet the way and the extent to which intracellular dynamics influence it remains elusive. In this work the role of cytoplasmic streaming induced by neuronal activity on ADC in neural cells was investigated. A hippocampal neuron was modeled and the effect of the forces generated by action potential (AP) streaming were numerically simulated. Coupling Navier-Stokes equations with elastic solid equations and AP forces enabled us to obtain the generated intracellular flow which then was used in transport equations to calculate concentration of the diffusion propagator and its variance over the computational domain. A significant increase of 27% in ADC was observed at AP firing frequency of 200 Hertz. Furthermore, this enhancement increases quasi-linearly with frequency. This work demonstrates that the effect of AP-and the subsequent generated intracellular flow-on ADC is non-negligible; therefore, disturbing AP firing can result in a reduction in measured ADC values. These findings could improve the current understanding of ADC reduction under pathological conditions and lay a foundation for future studies on this topic.<br /> (© 2026 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>ADC; DWI; diffusion; intracellular streaming; numerical simulation
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260601 <i>Date Completed: </i>20260610 <i>Latest Revision: </i>20260924
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260925
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1088/2057-1976/ae7576
– Name: AN
  Label: PMID
  Group: ID
  Data: 42225124
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42225124
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1088/2057-1976/ae7576
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Computer Simulation
        Type: general
      – SubjectFull: Diffusion
        Type: general
      – SubjectFull: Action Potentials physiology
        Type: general
      – SubjectFull: Diffusion Magnetic Resonance Imaging methods
        Type: general
      – SubjectFull: Neurons physiology
        Type: general
      – SubjectFull: Neurons cytology
        Type: general
      – SubjectFull: Hippocampus cytology
        Type: general
      – SubjectFull: Hippocampus physiology
        Type: general
      – SubjectFull: Cytoplasmic Streaming physiology
        Type: general
      – SubjectFull: Models, Neurological
        Type: general
    Titles:
      – TitleFull: The effect of action potential-induced intracellular streaming on neural diffusion weighted imaging: a computational analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sabourian A
      – PersonEntity:
          Name:
            NameFull: Vahidi B
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 10
              M: 06
              Text: 2026 Jun 10
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2057-1976
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Biomedical physics & engineering express
              Type: main
ResultId 1