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Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer's Disease.

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Τίτλος: Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer's Disease.
Συγγραφείς: Liu Y; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Li L; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Pu J; Kunming Jida Pharmaceutical Ltd. Co., Kunming, Yunnan 650101, China., Xiong Y; Kunming Jida Pharmaceutical Ltd. Co., Kunming, Yunnan 650101, China., Feng T; Pennsylvania State University, University Harrisburg, 17057, America, United States., Liu Z; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Zhou C; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Xu H; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Sayami N; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China., Yang J; Department of Pharmacy, Kunming Municipal Hospital of Traditional Chinese Medicine, Yunnan 650032, China., Zhou H; Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China., Gan P; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China. Electronic address: ganping@kmmu.edu.cn.
Πηγή: Brain research [Brain Res] 2026 Oct 01; Vol. 1888, pp. 150396. Date of Electronic Publication: 2026 Jun 01.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
Ιατρικοί όροι (MeSH): Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Drugs, Chinese Herbal*/pharmacology , Memory Disorders*/drug therapy , Memory Disorders*/metabolism, Retina/drug effects ; Retina/metabolism ; Synapses/drug effects ; Synapses/metabolism ; Hippocampus/metabolism ; Hippocampus/drug effects ; Brain/drug effects ; Brain/metabolism ; Disks Large Homolog 4 Protein/metabolism ; Animals ; Mice, Transgenic ; Mice ; Disease Models, Animal ; Male
Περίληψη: This study investigates whether early and sustained intervention with the Chinese herbal formula Yi Kang Bu Yuan (YKB) can modulate integrated networks to counteract Alzheimer 's disease (AD) progression. In APPswe/PSEN1dE9 transgenic mice, chronic YKB administration prevented both short- and long-term memory decline. This cognitive protection was supported by a coordinated rescue of pathology across the brain-retina axis: YKB restored vascular structural remodeling, as evidenced by increased cerebrovascular collagen IV and retinal CD31+ endothelia density. These vascular improvements occurred in parallel with short-term memory gain. Concurrently, YKB upregulated hippocampal PSD-95, which correlated with long-term fear memory rescue, and suppressed hippocampal GFAP+ astrogliosis. These results define a novel, multi-target therapeutic axis for YKB in early AD, demonstrating that coordinated modulation of the neurovascular unit and synaptic circuits can effectively ameliorate multifactorial deficits.
(Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Alzheimer’sdisease; Brain‒retinal-synapticNetwork; Memorydeficits; YiKangBuYuan(YKB)
Substance Nomenclature: 0 (Drugs, Chinese Herbal)
0 (Disks Large Homolog 4 Protein)
Entry Date(s): Date Created: 20260531 Date Completed: 20260704 Latest Revision: 20260704
Update Code: 20260705
DOI: 10.1016/j.brainres.2026.150396
PMID: 42219140
Βάση Δεδομένων: MEDLINE
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  Data: Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Pu+J%22">Pu J</searchLink>; Kunming Jida Pharmaceutical Ltd. Co., Kunming, Yunnan 650101, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Kunming Jida Pharmaceutical Ltd. Co., Kunming, Yunnan 650101, China.<br /><searchLink fieldCode="AU" term="%22Feng+T%22">Feng T</searchLink>; Pennsylvania State University, University Harrisburg, 17057, America, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Sayami+N%22">Sayami N</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Pharmacy, Kunming Municipal Hospital of Traditional Chinese Medicine, Yunnan 650032, China.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.<br /><searchLink fieldCode="AU" term="%22Gan+P%22">Gan P</searchLink>; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China. Electronic address: ganping@kmmu.edu.cn.
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  Data: <searchLink fieldCode="MM" term="%22Alzheimer+Disease%22">Alzheimer Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Alzheimer+Disease+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Alzheimer+Disease%22">Alzheimer Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Alzheimer+Disease+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Alzheimer+Disease%22">Alzheimer Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Alzheimer+Disease+pathology%22">pathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Drugs%2C+Chinese+Herbal%22">Drugs, Chinese Herbal*</searchLink>/<searchLink fieldCode="MM" term="%22Drugs%2C+Chinese+Herbal+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+drug+therapy%22">drug therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Memory+Disorders%22">Memory Disorders*</searchLink>/<searchLink fieldCode="MM" term="%22Memory+Disorders+metabolism%22">metabolism</searchLink><br /><searchLink fieldCode="MH" term="%22Retina%22">Retina</searchLink>/<searchLink fieldCode="MH" term="%22Retina+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Retina%22">Retina</searchLink>/<searchLink fieldCode="MH" term="%22Retina+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Synapses%22">Synapses</searchLink>/<searchLink fieldCode="MH" term="%22Synapses+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Synapses%22">Synapses</searchLink>/<searchLink fieldCode="MH" term="%22Synapses+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Hippocampus%22">Hippocampus</searchLink>/<searchLink fieldCode="MH" term="%22Hippocampus+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Hippocampus%22">Hippocampus</searchLink>/<searchLink fieldCode="MH" term="%22Hippocampus+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Brain%22">Brain</searchLink>/<searchLink fieldCode="MH" term="%22Brain+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Brain%22">Brain</searchLink>/<searchLink fieldCode="MH" term="%22Brain+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Disks+Large+Homolog+4+Protein%22">Disks Large Homolog 4 Protein</searchLink>/<searchLink fieldCode="MH" term="%22Disks+Large+Homolog+4+Protein+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%2C+Transgenic%22">Mice, Transgenic</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study investigates whether early and sustained intervention with the Chinese herbal formula Yi Kang Bu Yuan (YKB) can modulate integrated networks to counteract Alzheimer 's disease (AD) progression. In APPswe/PSEN1dE9 transgenic mice, chronic YKB administration prevented both short- and long-term memory decline. This cognitive protection was supported by a coordinated rescue of pathology across the brain-retina axis: YKB restored vascular structural remodeling, as evidenced by increased cerebrovascular collagen IV and retinal CD31<superscript>+</superscript> endothelia density. These vascular improvements occurred in parallel with short-term memory gain. Concurrently, YKB upregulated hippocampal PSD-95, which correlated with long-term fear memory rescue, and suppressed hippocampal GFAP<superscript>+</superscript> astrogliosis. These results define a novel, multi-target therapeutic axis for YKB in early AD, demonstrating that coordinated modulation of the neurovascular unit and synaptic circuits can effectively ameliorate multifactorial deficits.<br /> (Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
  Label: Contributed Indexing
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  Data: <i>Keywords: </i>Alzheimer’sdisease; Brain‒retinal-synapticNetwork; Memorydeficits; YiKangBuYuan(YKB)
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  Data: 10.1016/j.brainres.2026.150396
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      – TitleFull: Early and sustained Intervention with YKB Modulates the Cerebro-Retinal-Synaptic Network to Ameliorate Memory Deficits in Alzheimer's Disease.
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