Academic Journal
ABI5 and ABI3 mediate FIS-PRC2 recruitment to IKU2 and modulate endosperm cellularization during seed development.
| Τίτλος: | ABI5 and ABI3 mediate FIS-PRC2 recruitment to IKU2 and modulate endosperm cellularization during seed development. |
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| Συγγραφείς: | Gan S; College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong Province, China. Electronic address: gan123shuo@126.com. |
| Πηγή: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Aug 20; Vol. 827, pp. 154024. Date of Electronic Publication: 2026 May 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| Ιατρικοί όροι (MeSH): | Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Endosperm*/metabolism , Endosperm*/growth & development , Endosperm*/genetics , Endosperm*/cytology , Arabidopsis*/metabolism , Arabidopsis*/genetics , Arabidopsis*/growth & development , Transcription Factors*/metabolism , Transcription Factors*/genetics , Seeds*/growth & development , Seeds*/metabolism , Seeds*/genetics , Basic-Leucine Zipper Transcription Factors*/metabolism , Basic-Leucine Zipper Transcription Factors*/genetics , Polycomb Repressive Complex 2*/metabolism , Polycomb Repressive Complex 2*/genetics, Histones/metabolism ; Gene Expression Regulation, Plant ; Promoter Regions, Genetic ; Gene Expression Regulation, Developmental |
| Περίληψη: | Seed size is tightly associated with endosperm proliferation and the onset of cellularization. The mitotic proliferation rate of the early endosperm and the initiation timing of cellularization act as key developmental nodes that determine final seed volume and weight. In Arabidopsis thaliana, the FERTILIZATION-INDEPENDENT SEED Polycomb Repressive Complex 2 (FIS-PRC2) performs crucial functions throughout gametogenesis and seed development. Here, we report that the transcription factors ABSCISIC ACID-INSENSITIVE 5 (ABI5) and ABSCISIC ACID-INSENSITIVE 3 (ABI3) directly bind to the promoter of the core endosperm regulatory gene IKU2 and repress its transcription. Moreover, FIS-PRC2 is recruited to the IKU2 promoter via physical interaction with promoter-bound ABI5. FIS-PRC2 further facilitates the deposition of the repressive H3K27me3 epigenetic mark at the IKU2 locus. Collectively, our results reveal that ABI5 and ABI3 modulate the expression of endosperm developmental genes by recruiting the FIS-PRC2 complex. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest We declare no conflicts of interest. The authors declare that all data supporting the findings of this study are available within the paper and its supplementary information files. |
| Contributed Indexing: | Keywords: ABI3; ABI5; Endosperm development; H3K27me3; MEA |
| Substance Nomenclature: | 0 (Arabidopsis Proteins) 0 (Transcription Factors) 0 (ABI3 protein, Arabidopsis) 0 (ABI5 protein, Arabidopsis) 0 (Basic-Leucine Zipper Transcription Factors) 0 (Histones) 0 (PRC2 protein, Arabidopsis) EC 2.1.1.43 (Polycomb Repressive Complex 2) |
| Entry Date(s): | Date Created: 20260530 Date Completed: 20260612 Latest Revision: 20260612 |
| Update Code: | 20260613 |
| DOI: | 10.1016/j.bbrc.2026.154024 |
| PMID: | 42217415 |
| Βάση Δεδομένων: | MEDLINE |
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