Inositol Hexaphosphate as a Metabolic Rheostat: Reprogramming and Plasticity in Stem Cells and Disease States.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Inositol Hexaphosphate as a Metabolic Rheostat: Reprogramming and Plasticity in Stem Cells and Disease States.
Συγγραφείς:	Lin JY; Department of Audiology and Speech-Language Pathology, Mackay Medical University, 252005 New Taipei City, Taiwan.; Institute of Biomedical Sciences, Mackay Medical University, 252005 New Taipei City, Taiwan.; Institute of Brain Science, National Yang Ming Chiao Tung University, 112304 Taipei City, Taiwan., Yang CCH; Institute of Brain Science, National Yang Ming Chiao Tung University, 112304 Taipei City, Taiwan.; Sleep Research Center, National Yang Ming Chiao Tung University, 112304 Taipei City, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, 112304 Taipei City, Taiwan., Hsu YC; Department of Audiology and Speech-Language Pathology, Mackay Medical University, 252005 New Taipei City, Taiwan.; Institute of Biomedical Sciences, Mackay Medical University, 252005 New Taipei City, Taiwan.
Πηγή:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2026 May 22; Vol. 31 (5), pp. 49611.
Τύπος έκδοσης:	Journal Article; Review
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Print Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE
Imprint Name(s):	Publication: 2022- : Singapore : IMR Press Original Publication: Searington, NY : Frontiers in Bioscience
Ιατρικοί όροι (MeSH):	Phytic Acid/metabolism , Phytic Acid/pharmacology , Stem Cells/metabolism , Neoplasms/metabolism , Neoplasms/pathology , Cellular Reprogramming, Mitochondria/metabolism ; Humans ; Metabolic Reprogramming ; Animals ; Signal Transduction ; Glycolysis
Περίληψη:	Inositol hexaphosphate (IP6), a natural polyphosphorylated carbohydrate widely present in grains, legumes, and mammalian cells, has been increasingly recognized as a key regulator of cellular metabolism. This review examines how IP6 modulates metabolic reprogramming and plasticity in stem cells and disease states and discusses the implications of these mechanisms for translational medicine. IP6 influences central metabolic circuits, including glycolysis, mitochondrial oxidative phosphorylation, and redox balance. In stem cells, IP6 modulates energy utilization, enhances antioxidant defenses, and stabilizes pluripotency networks, thereby helping maintain self-renewal and delay premature differentiation. In pathological settings, such as cancer, IP6 acts as a metabolic checkpoint by attenuating aerobic glycolysis, modulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling pathway, and restoring mitochondrial integrity, which leads to growth arrest and apoptosis. These cancer-associated metabolic effects provide a framework for interpreting the IP6-mediated regulation of metabolic thresholds in stem and progenitor cells. Emerging evidence further suggests that IP6 can influence epigenetic landscapes through metabolite-dependent chromatin remodeling, thereby establishing a link between metabolic state and the transcriptional regulation of stemness and lineage commitment. In summary, IP6 is a versatile metabolic rheostat that preserves stem cell function while counteracting maladaptive metabolic reprogramming in disease states. Its pleiotropic effects are also implicated in neurodegeneration, hearing loss, and metabolic syndromes. Future studies should focus on defining IP6-regulated metabolic checkpoints, identifying direct molecular targets, and addressing pharmacokinetic and delivery challenges to help translate IP6-based strategies into regenerative and disease-modifying applications. (© 2026 The Author(s). Published by IMR Press.)
Grant Information:	MOST 111-2314-B-715-009-MY3 National Science and Technology Council (NSTC) of the Taiwan Government; MMU-RD-114-1B-P005 Mackay Medical University; MMU-RD-114-RM-G001-02 Mackay Medical University
Contributed Indexing:	Keywords: apoptosis; biomedical; glycolysis; metabolic reprogramming; phytic acid; stem cell; translational science
Substance Nomenclature:	7IGF0S7R8I (Phytic Acid)
Entry Date(s):	Date Created: 20260530 Date Completed: 20260717 Latest Revision: 20260717
Update Code:	20260717
DOI:	10.31083/FBL49611
PMID:	42216532
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	2768-6698
DOI:	10.31083/FBL49611