Academic Journal
The Thiol-Redox Biochemistry of Trypanosomatids: A New Perspective Based on Known and New Actors.
| Τίτλος: | The Thiol-Redox Biochemistry of Trypanosomatids: A New Perspective Based on Known and New Actors. |
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| Συγγραφείς: | Comini MA; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay., Graña M; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay., Manta B; Institut Pasteur de Montevideo, Mataojo 2020, CP 11400 Montevideo, Uruguay. |
| Πηγή: | Biochemistry [Biochemistry] 2026 Jun 16; Vol. 65 (12), pp. 1873-1899. Date of Electronic Publication: 2026 May 28. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Sulfhydryl Compounds*/metabolism , Sulfhydryl Compounds*/chemistry , Glutathione*/analogs & derivatives , Glutathione*/metabolism , Glutathione*/chemistry , Trypanosomatina*/metabolism , Protozoan Proteins*/metabolism , Protozoan Proteins*/chemistry, Thioredoxins/metabolism ; Thioredoxins/chemistry ; Spermidine/analogs & derivatives ; Spermidine/metabolism ; Spermidine/chemistry ; Glutaredoxins/metabolism ; Glutaredoxins/chemistry ; Oxidation-Reduction ; Animals |
| Περίληψη: | Maintaining thiol redox homeostasis is key for cell viability and development. Therefore, all organisms are equipped with redox systems conformed by redox-active proteins and low-molecular-weight thiols that facilitate target-specific delivery of electrons from NADPH to different (macro)molecules. Trypanosomatids are early branching single-cell eukaryotes harboring a unique thiol-redox system centered on the use of trypanothione (bis-glutathionylspermidine) as a low-molecular-weight thiol-redox cofactor. The irruption of trypanothione in these organisms acted as a major and positive selective pressure that shaped their redox biochemistry. The most radical changes involved the loss of otherwise highly conserved and indispensable glutathione reductase and thioredoxin reductase genes and the concomitant assignment of secondary roles to the related redoxins (glutaredoxins and thioredoxins). Here, we revise the state-of-the-art on the field and provide new research perspectives based on the identification of novel members of the thioredoxin-fold family. |
| Contributed Indexing: | Keywords: CXXC motif; kinetoplastids; leishmania; redoxin; thiol; thioredoxin-fold; trypanosoma; trypanothione |
| Substance Nomenclature: | 0 (Sulfhydryl Compounds) GAN16C9B8O (Glutathione) 52500-60-4 (Thioredoxins) U87FK77H25 (Spermidine) 96304-42-6 (trypanothione) 0 (Glutaredoxins) 0 (Protozoan Proteins) |
| Entry Date(s): | Date Created: 20260528 Date Completed: 20260616 Latest Revision: 20260616 |
| Update Code: | 20260616 |
| DOI: | 10.1021/acs.biochem.6c00079 |
| PMID: | 42207921 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-4995 |
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| DOI: | 10.1021/acs.biochem.6c00079 |