Academic Journal
Do animal models represent the diversity of clinical Parkinson's disease?
| Τίτλος: | Do animal models represent the diversity of clinical Parkinson's disease? |
|---|---|
| Συγγραφείς: | Massaro Cenere M; Fondazione Santa Lucia IRCCS, Department of Experimental Neuroscience, Rome, Italy., Schirinzi T; University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy., Ledonne A; Fondazione Santa Lucia IRCCS, Department of Experimental Neuroscience, Rome, Italy; University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy. Electronic address: ada.ledonne@uniroma2.it., Mercuri NB; Fondazione Santa Lucia IRCCS, Department of Experimental Neuroscience, Rome, Italy; University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy. Electronic address: mercurin@uniroma2.it. |
| Πηγή: | Current opinion in neurobiology [Curr Opin Neurobiol] 2026 Aug; Vol. 99, pp. 103220. Date of Electronic Publication: 2026 May 26. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Current Biology Country of Publication: England NLM ID: 9111376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6882 (Electronic) Linking ISSN: 09594388 NLM ISO Abbreviation: Curr Opin Neurobiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, UK : Current Biology, c1991- |
| Ιατρικοί όροι (MeSH): | Parkinson Disease*/pathology , Parkinson Disease*/genetics , Parkinson Disease*/physiopathology , Parkinson Disease*/etiology , Disease Models, Animal*, Animals ; Humans |
| Περίληψη: | Parkinson's disease (PD) is a multifactorial and progressive neurodegenerative disorder characterized by a complex symptomatology, including a broad spectrum of motor and non-motor symptoms. Disease modeling in animals represents a keystone part of the research aimed at understanding molecular bases driving PD onset, and specific mechanisms shaping pathological trajectories along disease progression, sustaining the inter-individual variability in PD manifestation. Multiple experimental approaches using toxins, viral vectors, and genetic perturbations have been developed to reproduce key PD features in animals, resulting in a wide variety of models. However, a minority of models show multiple aspects of PD-related phenomenology. In this short review, we provide a synthetic description of selected rodent PD models, including those based on stronger etiological construct validity as well as newly developed models, and discuss their strengths and limitations in reproducing PD features. The main intention is to provide a simple resource for selecting optimal PD models that show multiple histopathological and behavioral alterations, thus more closely mirroring clinical PD complexity. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Entry Date(s): | Date Created: 20260526 Date Completed: 20260722 Latest Revision: 20260722 |
| Update Code: | 20260723 |
| DOI: | 10.1016/j.conb.2026.103220 |
| PMID: | 42191412 |
| Βάση Δεδομένων: | MEDLINE |
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