Academic Journal
Antifungal activity of Tetradenia riparia essential oil against dermatophytes: effects of nanoencapsulation and molecular docking insights into CYP51 interaction.
| Τίτλος: | Antifungal activity of Tetradenia riparia essential oil against dermatophytes: effects of nanoencapsulation and molecular docking insights into CYP51 interaction. |
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| Συγγραφείς: | Makimori RY; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Endo EH; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Costa GM; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Ribas PF; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Silva GCC; Postgraduate Program in Biotechnology Applied to Agriculture and Postgraduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, PR, Brazil., Gazim ZC; Postgraduate Program in Biotechnology Applied to Agriculture and Postgraduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, PR, Brazil., Nakamura CV; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Ueda-Nakamura T; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil., Filho BPD; Postgraduate Program in Pharmaceutical Sciences, State University of Maringá, PR, Brazil. Electronic address: bpdfilho@uem.br. |
| Πηγή: | Microbial pathogenesis [Microb Pathog] 2026 Aug; Vol. 217, pp. 108591. Date of Electronic Publication: 2026 May 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London ; Orlando : Academic Press, c1986- |
| Ιατρικοί όροι (MeSH): | Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry , Arthrodermataceae*/drug effects , Arthrodermataceae*/growth & development, Microsporum/drug effects ; Microsporum/growth & development ; Fluconazole/pharmacology ; Nystatin/pharmacology ; Nanoparticles/chemistry ; Trichophyton/drug effects ; Molecular Docking Simulation ; Microbial Sensitivity Tests ; Drug Synergism |
| Περίληψη: | Tetradenia riparia essential oil (EO) has emerged as a potential natural antifungal agent against dermatophytes. This study evaluated the antifungal activity of free and nanoencapsulated EO against Trichophyton mentagrophytes and Microsporum gypseum, and investigated potential molecular interactions through in silico analysis. The EO exhibited concentration-dependent antifungal activity and inhibited hyphal elongation. Synergistic interactions with fluconazole and nystatin were observed, leading to significant reductions in minimum inhibitory concentration (MIC) values. Nanoencapsulation in poly(lactic acid) nanoparticles preserved antifungal activity while improving chemical stability and reducing cytotoxicity. In an ex vivo nail infection model, both formulations reduced fungal growth and induced marked structural damage. Molecular docking analysis suggested that major terpenoid constituents may interact with the CYP51 binding site, providing preliminary mechanistic insights. Overall, these findings indicate that T. riparia EO, particularly in nanoencapsulated form, represents a promising candidate for further investigation as a topical or adjunctive antifungal strategy. (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest X The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Benedito Prado Dias Filho reports financial support was provided by National Council for Scientific and Technological Development. Benedito Prado Dias Filho reports financial support was provided by Coordination for the improvement of Higher Education Personnel. Benedito Prado Dias Filho reports financial support was provided by Araucaria Foundation. BENEDITO PRADO DIAS FILHO reports financial support was provided by Finep. Reports a relationship with that includes:. Has patent pending to. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antifungal activity; CYP51; Dermatophytes; Essential oil; Molecular docking; Nanoencapsulation; Onychomycosis; Tetradenia riparia |
| Substance Nomenclature: | 0 (Antifungal Agents) 0 (Oils, Volatile) 8VZV102JFY (Fluconazole) 1400-61-9 (Nystatin) |
| SCR Organism: | Trichophyton mentagrophytes |
| Entry Date(s): | Date Created: 20260526 Date Completed: 20260617 Latest Revision: 20260617 |
| Update Code: | 20260618 |
| DOI: | 10.1016/j.micpath.2026.108591 |
| PMID: | 42190995 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1096-1208 |
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| DOI: | 10.1016/j.micpath.2026.108591 |