Academic Journal
Resetting substrate loading enables recovery of inhibited anammox granular reactors through energy-associated response.
| Τίτλος: | Resetting substrate loading enables recovery of inhibited anammox granular reactors through energy-associated response. |
|---|---|
| Συγγραφείς: | Zhang X; National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai, China., Jie C; National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai, China., Zhuang JL; Suzhou University of Science and Technology, Suzhou, China; Jiangsu Province Engineering Research Center of Water Resilient Cities, Suzhou, China. Electronic address: zhuangjl@usts.edu.cn., Wang HJ; Suzhou University of Science and Technology, Suzhou, China; Jiangsu Province Engineering Research Center of Water Resilient Cities, Suzhou, China., Liu YD; National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, China., Huang TY; Suzhou University of Science and Technology, Suzhou, China; Jiangsu Province Engineering Research Center of Water Resilient Cities, Suzhou, China., Qian FY; Suzhou University of Science and Technology, Suzhou, China; Jiangsu Province Engineering Research Center of Water Resilient Cities, Suzhou, China., Wang ZY; State Key Laboratory of Soil Pollution Control and Safety, Zhejiang University, Hangzhou, China., Zhao YX; State Key Laboratory of Soil Pollution Control and Safety, Zhejiang University, Hangzhou, China., Shapleigh JP; Department of Microbiology, Cornell University, Ithaca, USA., Li W; National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery, East China University of Science and Technology, Shanghai, China; Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, USA. Electronic address: weili29@asu.edu. |
| Πηγή: | Bioresource technology [Bioresour Technol] 2026 Oct; Vol. 457, pp. 134982. Date of Electronic Publication: 2026 May 25. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Barking, Essex, England : New York, N.Y. : Elsevier Applied Science ; Elsevier Science Pub. Co., 1991- |
| Ιατρικοί όροι (MeSH): | Bioreactors*/microbiology , Ammonium Compounds*/metabolism , Energy Metabolism* , Anaerobic Ammonia Oxidation*, Bacteria/metabolism ; Bacteria/genetics ; Oxidation-Reduction ; Nitrites |
| Περίληψη: | Substrate inhibition remains a critical bottleneck for the stable operation and recovery of anaerobic ammonium oxidation (anammox) reactors. Although reducing influent substrate concentrations is the most commonly adopted recovery strategy, the appropriate reset point for restarting an inhibited reactor remains poorly understood. Here, using a continuous substrate-inhibited anammox granular reactor as a model system, we showed that severe inhibition occurred at influent ammonium and nitrite concentrations of 400 and 480 mg·L-1, respectively. Notably, reducing the influent concentrations to 300 and 360 mg·L-1, which had previously sustained stable high-rate nitrogen removal, was insufficient to restore reactor performance. Successful recovery was only achieved after further decreasing the influent concentrations to 150 and 180 mg·L-1, respectively. Metatranscriptomic and genome-resolved analyses showed that the dominant anammox bacterium, Candidatus Kuenenia stuttgartiensis (AMX1), remained in a state of energy-metabolism dysregulation under substrate inhibition, as evidenced by significant upregulation of hydrazine dehydrogenase (hdh; log (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Adenylate energy charge; Bioenergetic stress; Metatranscriptomics; Reactor restart |
| Substance Nomenclature: | 0 (Ammonium Compounds) 0 (Nitrites) |
| Entry Date(s): | Date Created: 20260526 Date Completed: 20260612 Latest Revision: 20260612 |
| Update Code: | 20260613 |
| DOI: | 10.1016/j.biortech.2026.134982 |
| PMID: | 42190967 |
| Βάση Δεδομένων: | MEDLINE |
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