Academic Journal
High-density lipoprotein cholesterol and cognitive function in patients undergoing hemodialysis.
| Title: | High-density lipoprotein cholesterol and cognitive function in patients undergoing hemodialysis. |
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| Authors: | Kato K; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.; Division of Molecular Epidemiology, The Jikei University School of Medicine, Tokyo, Japan., Nakashima A; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. a-nakashima@jikei.ac.jp., Aizawa C; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.; Division of Molecular Epidemiology, The Jikei University School of Medicine, Tokyo, Japan., Kobayashi A; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Shinagawa S; Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan., Ohkido I; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Urashima M; Division of Molecular Epidemiology, The Jikei University School of Medicine, Tokyo, Japan., Yokoo T; Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. |
| Source: | Clinical and experimental nephrology [Clin Exp Nephrol] 2026 Aug; Vol. 30 (8), pp. 1237-1244. Date of Electronic Publication: 2026 May 26. |
| Publication Type: | Journal Article; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: Japan NLM ID: 9709923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7799 (Electronic) Linking ISSN: 13421751 NLM ISO Abbreviation: Clin Exp Nephrol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2008- : Tokyo : Springer Original Publication: Tokyo : Published for the Japanese Society of Nephrology by Churchill Livingstone, c1997- |
| MeSH Terms: | Renal Dialysis*/adverse effects , Cholesterol, HDL*/blood , Cognitive Dysfunction*/blood , Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/psychology , Cognitive Dysfunction*/etiology , Cognition*, Biomarkers/blood ; Triglycerides/blood ; Cholesterol, LDL/blood ; Humans ; Female ; Cross-Sectional Studies ; Male ; Aged ; Japan ; Risk Factors ; Aged, 80 and over ; Multivariate Analysis ; Mental Status and Dementia Tests ; Linear Models ; Up-Regulation |
| Abstract: | Background: Cognitive impairment is highly prevalent among older adults receiving maintenance hemodialysis; however, its pathophysiology is multifactorial and poorly understood. Evidence linking the lipid-profile components to cognitive function in patients undergoing hemodialysis remains limited. To address this evidence gap, we evaluated the associations between serum lipid-profile components and global cognitive function. Methods: We conducted an exploratory cross-sectional study of patients aged ≥ 65 years receiving maintenance hemodialysis at seven dialysis centers in Japan. Serum high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were measured immediately before the first hemodialysis session of the week. Global cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Multivariate linear regression analyses were performed, adjusting for clinical comorbidities and markers of nutritional status, inflammation, and dialysis adequacy. Results: Among 265 participants (median age, 74 years; 67.6% male), higher serum HDL-C levels were independently associated with higher MoCA scores (fully adjusted model: β = 0.06; 95% confidence interval, 0.03-0.10; P < 0.001) and MMSE scores (β = 0.03; 95% confidence interval, 0.01-0.06; P = 0.031). In contrast, the serum LDL-C and TG levels showed no significant associations with either cognitive assessment. Conclusion: Higher serum HDL-C levels were associated with better global cognitive function in older patients undergoing hemodialysis, whereas the LDL-C and TG levels were not significantly related to cognitive scores. (© 2026. The Author(s), under exclusive licence to Japanese Society of Nephrology.) |
| Competing Interests: | Declarations. Conflict of interest: The authors have declared that no conflict of interest exists. Ethical approval: All procedures were performed in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The institutional review board of The Jikei University School of Medicine (Approval No.: 33—183(10800)) approved the study. Informed consent: Informed consent was obtained from all individual participants included in the study. |
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| Grant Information: | 20K17259 JSPS KAKENHI; 23K07727 JSPS KAKENHI; JKFB21-15 Grant for Pathophysiological Research Conference in Chronic Kidney Disease from the Kidney Foundation, Japan; JKFB23-7 Grant for Pathophysiological Research Conference in Chronic Kidney Disease from the Kidney Foundation, Japan |
| Contributed Indexing: | Keywords: Cognitive dysfunction; Hemodialysis; High-density lipoprotein cholesterol |
| Substance Nomenclature: | 0 (Cholesterol, HDL) 0 (Biomarkers) 0 (Triglycerides) 0 (Cholesterol, LDL) |
| Entry Date(s): | Date Created: 20260526 Date Completed: 20260717 Latest Revision: 20260717 |
| Update Code: | 20260717 |
| DOI: | 10.1007/s10157-026-02879-w |
| PMID: | 42189406 |
| Database: | MEDLINE |
| ISSN: | 1437-7799 |
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| DOI: | 10.1007/s10157-026-02879-w |