Academic Journal
Regional alterations of parvalbumin interneurons in human App knock-in mouse model of Alzheimer's disease pathology.
| Τίτλος: | Regional alterations of parvalbumin interneurons in human App knock-in mouse model of Alzheimer's disease pathology. |
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| Συγγραφείς: | Gonzalez MM; Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, United States. Electronic address: mercgonz@outlook.com., Magondu B; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, United States., Rowan MJM; Department of Cell Biology, Emory University School of Medicine, Atlanta, United States; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, United States., Forest CR; Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, United States. |
| Πηγή: | Neurobiology of aging [Neurobiol Aging] 2026 Oct; Vol. 166, pp. 41-49. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Elsevier Original Publication: Fayetteville, N.Y. : Ankho International. |
| Ιατρικοί όροι (MeSH): | Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/physiopathology , Alzheimer Disease*/genetics , Interneurons*/physiology , Interneurons*/pathology , Interneurons*/metabolism , Parvalbumins*/metabolism , Amyloid beta-Protein Precursor*/genetics , Amyloid beta-Protein Precursor*/metabolism , Entorhinal Cortex*/pathology , Entorhinal Cortex*/cytology , Entorhinal Cortex*/physiopathology , Entorhinal Cortex*/metabolism , Gene Knock-In Techniques*, Visual Cortex/cytology ; Visual Cortex/pathology ; Animals ; Disease Models, Animal ; Humans ; Mice, Transgenic |
| Περίληψη: | Early-stage Alzheimer's disease pathology correlates with disrupted neuronal excitability, which can drive network and cognitive dysfunction even prior to neurodegeneration. However, the emergence and extent of these changes may vary by brain region and cell types situated in those regions. Here we aimed to investigate the effects of Alzheimer's disease pathology on different neuron subtypes in both the entorhinal cortex, a region known to be affected early in Alzheimer's disease, and the primary visual cortex, a relatively unaffected region. We designed and employed a semi-automated patch clamp electrophysiology apparatus to record from fast-spiking parvalbumin interneurons and excitatory neurons in these regions, recording from over 150 cells in 2 month old amyloid precursor protein knock-in (APP-KI) mice. In entorhinal cortex, amyloid overproduction resulted in parvalbumin interneuron hypoexcitability, whereas excitatory neurons were concurrently hyperexcitable. Conversely, neurons of either subclass were largely unaffected in the visual cortex. Together, these findings suggest that fast-spiking parvalbumin interneurons in the entorhinal cortex exhibit selective functional alterations in an early APP-driven state. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: APP; Alzheimer’s disease; Amyloid precursor protein; Electrophysiology; Interneurons; Parvalbumin |
| Substance Nomenclature: | 0 (Parvalbumins) 0 (Amyloid beta-Protein Precursor) |
| Entry Date(s): | Date Created: 20260525 Date Completed: 20260611 Latest Revision: 20260612 |
| Update Code: | 20260612 |
| DOI: | 10.1016/j.neurobiolaging.2026.05.005 |
| PMID: | 42184608 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1558-1497 |
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| DOI: | 10.1016/j.neurobiolaging.2026.05.005 |