Academic Journal
HIV and Tuberculosis Coinfection in Brazil: Cohort Profile Monitored by the Unified Health System (2015-2018).
| Τίτλος: | HIV and Tuberculosis Coinfection in Brazil: Cohort Profile Monitored by the Unified Health System (2015-2018). |
|---|---|
| Συγγραφείς: | de Souza EL; School of Public Health, Graduate Program in Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, Cerqueira César, São Paulo, São Paulo, Brazil. evylima19@gmail.com., Nemes MIB; Department of Preventive Medicine, School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil., Alves AM; Department of Preventive Medicine, School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil., Sato APS; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, São Paulo, Brazil. |
| Πηγή: | Journal of community health [J Community Health] 2026 Aug; Vol. 51 (4), pp. 656-666. Date of Electronic Publication: 2026 May 24. |
| Τύπος έκδοσης: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Netherlands NLM ID: 7600747 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3610 (Electronic) Linking ISSN: 00945145 NLM ISO Abbreviation: J Community Health Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Springer Original Publication: New York, Human Sciences Press. |
| Ιατρικοί όροι (MeSH): | Coinfection*/epidemiology , Coinfection*/drug therapy , HIV Infections*/epidemiology , HIV Infections*/drug therapy , Tuberculosis*/epidemiology , Tuberculosis*/drug therapy, Brazil/epidemiology ; Humans ; Male ; Adult ; Female ; Middle Aged ; Young Adult ; Cohort Studies ; Adolescent ; National Health Programs |
| Περίληψη: | To describe the sociodemographic and clinical profile of individuals with HIV-tuberculosis coinfection followed in services of the Brazilian Unified Health System (SUS), through the integration of data from the Qualiaids-Brazil Cohort and national health information systems. Methods: Nationwide observational study using data from the Qualiaids-BR Cohort, composed of people living with HIV/AIDS (PLWHA) who initiated antiretroviral therapy (ART) between 2015 and 2018 in SUS services participating in the Qualiaids 2016/2017 survey. Individuals with at least one episode of active tuberculosis after ART initiation were included. Results: A total of 7,747 individuals with HIV-tuberculosis coinfection were identified. The majority were men, young, mixed-race, with low educational levels, and residing in the Southeast region. Social vulnerabilities included alcohol, tobacco, or illicit drug use (> 20%). Half presented an initial viral load > 100,000 copies/mL and 60% had baseline CD4 counts < 200 cells/mm³. Regarding tuberculosis, 80.3% were new cases, 9.5% re-entries, and 5.7% relapses. Treatment duration was concentrated between 6 and 12 months, with a cure rate of 70.9% and abandonment in 10.4% of cases, of which 21.3% also discontinued ART. Conclusion: Data integration enabled a comprehensive profile of HIV-tuberculosis coinfection, consistent with national findings and marked by social vulnerabilities that impact adherence and outcomes. The high proportion of treatment abandonment, also associated with ART discontinuation, highlights systemic weaknesses and the need for integrated care strategies for individuals with HIV-tuberculosis coinfection. The findings reinforce the importance of promoting comprehensive and continuous care to mitigate the impacts of coinfection. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Consent for Publication: Not applicable. There are no personal data of any individual in the manuscript in any form. Ethics Approval: The study was approved by the Research Ethics Committee for Human Subjects of the School of Medicine of the University of São Paulo on January 23, 2020 (CAAE: 27659220.3.0000.0065; Opinion: 3.807.435). |
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| Contributed Indexing: | Keywords: Coinfection; HIV; Health information systems; Tuberculosis; Unified health system |
| Entry Date(s): | Date Created: 20260524 Date Completed: 20260720 Latest Revision: 20260821 |
| Update Code: | 20260822 |
| PubMed Central ID: | PMC13385018 |
| DOI: | 10.1007/s10900-026-01585-8 |
| PMID: | 42177713 |
| Βάση Δεδομένων: | MEDLINE |
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