Academic Journal
ThyroidPrint: Thyroid Genetic Classifier Long-Term Follow-Up of Benign Called Lesions.
| Τίτλος: | ThyroidPrint: Thyroid Genetic Classifier Long-Term Follow-Up of Benign Called Lesions. |
|---|---|
| Συγγραφείς: | Lustig N; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Domínguez JM; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Vargas-Salas S; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Hernandez MP; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Mosso L; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Solorzano M; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Fuentes I; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Madison A; Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile.; UC Christus, Santiago, Chile., Cruz F; UC Christus, Santiago, Chile.; Department of Radiology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Loyola S; UC Christus, Santiago, Chile.; Department of Radiology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., León A; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Montero PH; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Domínguez F; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Camus M; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Solar A; UC Christus, Santiago, Chile.; Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Zoroquiain P; UC Christus, Santiago, Chile.; Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., Roa JC; UC Christus, Santiago, Chile.; Department of Anatomic Pathology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile., González HE; UC Christus, Santiago, Chile.; Department of Surgical Oncology, School of Medicine Pontificia Universidad Católica de Chile, Santiago, Chile. |
| Πηγή: | Clinical endocrinology [Clin Endocrinol (Oxf)] 2026 Oct; Vol. 105 (4), pp. 486-492. Date of Electronic Publication: 2026 May 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2003->: Oxford : Blackwell Publishing Original Publication: Oxford, Blackwell Scientific Publications. |
| Ιατρικοί όροι (MeSH): | Thyroid Nodule*/genetics , Thyroid Nodule*/pathology , Thyroid Nodule*/diagnosis , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/diagnosis , Thyroid Gland*/pathology, Humans ; Female ; Follow-Up Studies ; Male ; Prospective Studies ; Middle Aged ; Adult ; Aged ; Ultrasonography |
| Περίληψη: | Background: The management of indeterminate thyroid nodules (ITNs) remains challenging, with molecular classifiers emerging as valuable tools for risk stratification. ThyroidPrint is a novel quantitative PCR-based 10-gene classifier designed to predict benignity in ITNs, enabling more informed clinical decision-making. Objective: To evaluate the long-term follow-up (≥ 5 years) of patients with a benign ThyroidPrint result managed via active surveillance, assessing the safety, durability and clinical utility of the test in a real-world setting. Methods: This prospective, single-centre study included 104 patients with indeterminate cytology (Bethesda III/IV) and a previous benign ThyroidPrint result, followed for a median of 5.3 years. Ultrasound monitoring and clinical assessments guided management, with surgery reserved for significant nodule growth or patient preference. Outcomes included the proportion of patients remaining under surveillance, nodule growth and surgical pathology. Results: Of the 104 patients with benign ThyroidPrint results, 94.2% remained under active surveillance at 5 years, with only 5.8% undergoing surgery, all of which confirmed benign or low-risk histology. The false-negative rate was minimal among resected nodules supports the test's safety as a rule-out tool. Ultrasonographic monitoring proved effective for early detection of changes in warranting intervention. Conclusions: Long-term follow-up demonstrates that ThyroidPrint provides a reliable, safe and durable approach to managing ITN, significantly reducing unnecessary surgeries while maintaining a low rate of missed malignancies. These findings reinforce its role in personalised patient management and support structured surveillance protocols for selected patients. (© 2026 John Wiley & Sons Ltd.) |
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| Contributed Indexing: | Keywords: genetic classifier; indeterminate thyroid cytology; long‐term follow‐up |
| Entry Date(s): | Date Created: 20260522 Date Completed: 20260901 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| PubMed Central ID: | PMC13532118 |
| DOI: | 10.1111/cen.70161 |
| PMID: | 42170995 |
| Βάση Δεδομένων: | MEDLINE |
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