Academic Journal
Combustion aerosols from mineral oil industrial fires: Physicochemical characterization and toxicity in bronchial epithelial cells at the air-liquid interface.
| Τίτλος: | Combustion aerosols from mineral oil industrial fires: Physicochemical characterization and toxicity in bronchial epithelial cells at the air-liquid interface. |
|---|---|
| Συγγραφείς: | Méausoone C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000, Rouen, France., Rogez-Florent T; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000, Rouen, France., Castilla C; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CARMeN UMR 6064, F-76000, Rouen, France., Chevalier L; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, GPM UMR 6634, F-76000, Rouen, France., Bouzar C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000, Rouen, France., Cardinael P; Univ Rouen Normandie, Normandie Univ, SMS UR 3233, F-76000, Rouen, France., Legeard T; Univ Rouen Normandie, Normandie Univ, SMS UR 3233, F-76000, Rouen, France., Tisse S; Univ Rouen Normandie, Normandie Univ, SMS UR 3233, F-76000, Rouen, France., Yon J; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CORIA UMR 6614, F-76000, Rouen, France., Portet-Koltalo F; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CARMeN UMR 6064, F-76000, Rouen, France., Varea E; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CORIA UMR 6614, F-76000, Rouen, France., Patte-Rouland B; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CORIA UMR 6614, F-76000, Rouen, France., Fournier M; Univ Rouen Normandie, Université Caen Normandie, CNRS, Normandie Univ, M2C UMR 6143, F-76000, Rouen, France., Coppalle A; Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CORIA UMR 6614, F-76000, Rouen, France., Monteil C; Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000, Rouen, France. Electronic address: christelle.monteil@univ-rouen.fr. |
| Πηγή: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2026 Aug 01; Vol. 402, pp. 128396. Date of Electronic Publication: 2026 May 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987- |
| Ιατρικοί όροι (MeSH): | Epithelial Cells*/drug effects , Air Pollutants*/toxicity , Air Pollutants*/analysis , Air Pollutants*/chemistry , Mineral Oil*/toxicity , Mineral Oil*/chemistry , Fires*, Aerosols/toxicity ; Aerosols/analysis ; Aerosols/chemistry ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Bronchi/cytology ; Particulate Matter/toxicity ; Humans ; Cell Line |
| Περίληψη: | Industrial fires involving petroleum-based materials are episodic but can be major sources of atmospheric pollution, releasing complex combustion aerosols into the atmosphere, raising concerns about potential health effects for nearby populations and firefighters. However, the hazard assessment of such emissions remains challenging due to their chemical complexity. In this context, the aim of this study was to combine physico-chemical characterization, controlled aerosol exposure at the air-liquid interface, and biological responses to assess the hazards of combustion aerosols generated from mineral oils, with and without engine lubricant additives, following an industrial fire scenario. Comprehensive targeted and untargeted chemical analyses revealed shared polycyclic aromatic hydrocarbon (PAH) signatures alongside specific tracers found in aerosols generated from mineral oils containing additives, including sulfur-containing compounds previously detected in environmental samples following a fire event. Microphysical characterization showed that soot particles remained in the nanoscale range and exhibited distinct deposition efficiencies under air-liquid interface (ALI) exposure conditions. This enabled controlled exposure of bronchial epithelial cells (Beas-2B) to environmentally relevant concentrations observed during industrial fire events. Interestingly, aerosols generated from mineral oils containing additives induced lower cytotoxicity, which may be related to compositional differences, including the presence of antioxidant compounds. The relatively low intrinsic potential of the particulate fraction suggests that direct redox activity may not be the primary driver of toxicity. Instead, cytotoxicity effects may involve metabolic activation of organic compounds, such as PAH, or inflammatory signaling pathways. Overall, this study highlights the relevance of a multidisciplinary approach for better assessing the potential health hazards associated with industrial fire emissions. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Air-liquid interface; Bronchial epithelial cells; Combustion aerosols; Environmental toxicology; Industrial fire; Particulate matter |
| Substance Nomenclature: | 0 (Aerosols) 0 (Air Pollutants) 8020-83-5 (Mineral Oil) 0 (Polycyclic Aromatic Hydrocarbons) 0 (Particulate Matter) |
| Entry Date(s): | Date Created: 20260521 Date Completed: 20260717 Latest Revision: 20260717 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.envpol.2026.128396 |
| PMID: | 42167524 |
| Βάση Δεδομένων: | MEDLINE |
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